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MAPP

Mosquito Antiviral piRNA Pathway

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MAPP project word cloud

Explore the words cloud of the MAPP project. It provides you a very rough idea of what is the project "MAPP" about.

knock regulate 21 viruses strategies interplay aegypti viral medically sequence chikv interference 24 unlike molecules lines apathogenic nucleotide first rnai proteomics rnas immune protein small economically break nt experiments sequencing virus aedine innate transmission infected interactions extend interacting pi establishment subsequent molecular quantitative multidisciplinary time infectious regulating arbovirus cells proteins 29 interfering rna generate play borne identification vector comprehensively mosquito host aedes infections little arbo disease mechanism humans infection virology interaction mosquitoes reported cell mammalian arboviruses piwi pirna arthropod chikungunya pirnas si ensures persistent dengue spread mammals transmit involvement sirnas understand sirna antiviral

Project "MAPP" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.gla.ac.uk/researchinstitutes/iii/cvr/
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2017-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	coordinator	195˙454.00

Map

Project objective

Mosquitoes transmit several medically and economically important ARthropod-BOrne (arbo)viruses to mammals (including humans), such as dengue virus and chikungunya virus (CHIKV). Unlike infection in their mammalian host, infection in their arthropod vector is apathogenic and persistent due to the interplay between the virus and the innate immune responses. The main antiviral mechanism in mosquitoes is the sequence specific RNA break down mechanism- RNA interference (RNAi), specifically the 21 nucleotide (nt) long small interfering (si)RNAs are considered to play a key role; however, siRNAs are not likely to be essential for the establishment of persistent viral infection. Recently small RNA molecules derived from different pathway have been reported to have an antiviral role in aedine mosquitoes and derived cell lines: PIWI interacting (pi)RNAs (24-29 nt). Persistent infection ensures that mosquitoes remain infectious and if piRNAs control this process, they could play a key part in regulating subsequent arbovirus transmission to humans. Little is known about the piRNA pathway in mosquitoes and even less about its interaction with arbovirus infections. Most of the work has focused on the identification and analysis of (viral specific) small RNAs (siRNA and piRNAs) in infected mosquitoes, but little on the proteins and the protein-RNA interactions involved in these processes. The proposed research project will use a multidisciplinary approach that involves molecular virology with CHIKV, quantitative proteomics, RNA sequencing and knock down experiments in Aedes aegypti derived cells and mosquitoes to comprehensively understand for the first time the piRNA pathway, its involvement and importance to regulate arbovirus infections in aedine mosquitoes. The findings will extend our knowledge on the interactions between arboviruses and their mosquito vector and generate information that could be used in novel disease-spread control strategies.

Publications

List of publications.
year	authors and title	journal	last update
2017	Margus Varjak, Kevin Maringer, Mick Watson, Vattipally B. Sreenu, Anthony C. Fredericks, Emilie Pondeville, Claire L. Donald, Jelle Sterk, Joy Kean, Marie Vazeille, Anna-Bella Failloux, Alain Kohl, Esther Schnettler Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses published pages: e00144-17, ISSN: 2379-5042, DOI: 10.1128/mSphere.00144-17	mSphere 2/3	2019-07-24

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The information about "MAPP" are provided by the European Opendata Portal: CORDIS opendata.