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uDAS

An Automatic Microfluidic Device Assembly System

Total Cost €

EC-Contrib. €

Partnership

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uDAS project word cloud

Explore the words cloud of the uDAS project. It provides you a very rough idea of what is the project "uDAS" about.

micro lithography dimensions micromechanical pdms penetration multilayer platforms glass serial sequence reactions full times mudloc last ed hundreds sophisticated life complexity expertise tool layer generation microfluidics density convenient standard assembly consist frustrating 2012 industry contains manufactured expensive construction portability yield reagents parallel micrometer thousands layers dimensional solution critical microarray multidimensional direct protein limited soft fabricate chips erc platform prototype multiple academia automatic valves uncontrolled half device array proven assays first existent semi demands fabrication 85 das uses pave almost mainly microfluidic benefit biomedical sciences designed road 15 automated 2nd suffered

Project "uDAS" data sheet

The following table provides information about the project.

Coordinator	BAR ILAN UNIVERSITY Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 website: www.biu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-PoC
Funding Scheme	ERC-POC
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2016-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BAR ILAN UNIVERSITY BAR ILAN UNIVERSITY Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 website: www.biu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (RAMAT GAN)	coordinator	150˙000.00

Map

Project objective

Microfluidic systems, in general, have proven important platforms for biomedical assays. These systems benefit from reduced requirements for expensive reagents, short analysis times, and portability. Although microfluidic systems are convenient platforms, their use in the life sciences is still limited mainly due to the high-level fabrication expertise required for construction.

Integrated microfluidics is one of the most sophisticated three-dimensional (multi layer) solution. It requires soft lithography (PDMS based chips), for production of high complexity microfluidic systems (multiple serial or parallel processes). Integrated microfluidics in particular is almost non-existent in the industry due to the low yield and uncontrolled production process.

My ERC project (MUDLOC-2012) is to develop a microfluidic platform for multidimensional protein array analysis. It uses complex multilayer microfluidic devices that consist of 2 PDMS layers and a glass microarray. The integrated microfluidics system contains thousands of micromechanical valves in micrometer dimensions, controlling thousands of parallel reactions. Our research demands production of hundreds of such devices.

We, as all others who produce integrated microfluidics, suffered from frustrating low yield (15%). In order to improve fabrication yield and to fabricate devices with increased density, we designed and manufactured, a first of its kind, full production process sequence, semi automatic Microfluidic Device Assembly System (µDAS). This resulted in a direct increase of device complexity and yield (85%) over the last half year.

The 2nd generation automated µDAS prototype will become a generic assembly tool for soft lithography. µDAS will enable a critical production standard and process control, which will pave the road for significant penetration of complex integrated microfluidics technology into both academia and industry.

Publications

List of publications.
year	authors and title	journal	last update
2016	Dorit Avirahami, Sarit Kipper, Yair Glick, Ludmila Frolov, Ortal Guy, Efrat Michaely ON-The-Fly Microfluidic Device Assembly published pages: , ISSN: , DOI:	EMBL Conference Microfluidics 2016 1 every two years	2019-07-24
2017	Sarit Kipper, Ludmila Frolov, Ortal Guy, Michal Pellach, Yair Glick, Asaf Malichi, Binyamin A. Knisbacher, Efrat Barbiro-Michaely, Dorit Avrahami, Yehuda Yavets-Chen, Erez Y. Levanon, Doron Gerber Control and automation of multilayered integrated microfluidic device fabrication published pages: 557-566, ISSN: 1473-0197, DOI: 10.1039/C6LC01534D	Lab Chip 17/3	2019-07-24
2016	Glick Y., Ben-ari Y., Schwartz N., Nevenzal H., Ronen M., Kipper S., Golodnitsky R., Chen D., Avrahami D., Barbiro-michaely E., Gerber D. Alignment in multilayer microfluidics device A stumbling block published pages: , ISSN: , DOI:		2019-07-24

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The information about "UDAS" are provided by the European Opendata Portal: CORDIS opendata.