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CRYOMAT SIGNED

Antifreeze GlycoProtein Mimetic Polymers

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CRYOMAT project word cloud

Explore the words cloud of the CRYOMAT project. It provides you a very rough idea of what is the project "CRYOMAT" about.

polar polymers secrete scenarios needle death nature accessible pierces polymer proteins stem membranes macromolecular takes extremely mechanisms oil clinical peptide synthesis summary defense later extreme precision chemistry bio solution iri diverse sources mimetics cell maximize killing afgps thawing materials borne shaping environments employ indications storage whereby settings life wind cryopreservation fish clinically transfused biophysical blood elegant survive multidisciplinary effect turbines slow translation glyco surfaces platelets road cytotoxicity red inhibition revealed natural water cells shapes oceans synthetic crystals interactions resource biological rate zero sub living reproduce contributor enhanced inspiration crystal vinyl scalable found antifreeze inspired ice human food tunable modern limited desirable frozen recrystallization flourish donor

Project "CRYOMAT" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House city: COVENTRY postcode: CV4 8UW website: www.warwick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙496˙439 €
EC max contribution	1˙496˙439 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF WARWICK THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House city: COVENTRY postcode: CV4 8UW website: www.warwick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (COVENTRY)	coordinator	1˙496˙439.00

Map

Project objective

Fish living in polar oceans have evolved an elegant, macromolecular, solution to survive in sub-zero water: they secrete antifreeze (glyco)proteins (AFGPs) which have several ‘antifreeze’ effects, including ice recrystallization inhibition (IRI) - they slow the rate of ice crystal growth. Ice crystal growth is a major problem in settings as diverse as oil fields, wind turbines, road surfaces and frozen food. Analysis of the process of cryopreservation, whereby donor cells are frozen for later use, has revealed that ice recrystallization is a major contributor to cell death upon thawing. Enhanced cryopreservation methods are particularly needed for stem cell storage to maximize the use of this currently limited resource, but also to enable storage of clinically transfused cells such as platelets and red blood cells. AFGPs have thus far not found application in cryopreservation due to their low availability from natural sources, extremely challenging synthesis, indications of cytotoxicity, but more importantly they have a side effect of shaping ice crystals into needle-shapes which pierces cells’ membranes, killing them. The aim of this ambitious project is to take a multidisciplinary approach to develop synthetic polymers as tunable, scalable and accessible bio-mimetics of AFGPs, which specifically reproduce only the desirable IRI properties. Precision synthetic and biological methods will be applied to access both vinyl- and peptide- based materials with IRI activity. The bio-inspired approach taken here will include detailed biophysical analysis of the polymer-ice interactions and translation of this understanding to real cryopreservation scenarios using blood-borne cells and human stem cells. In summary, this ambitious project takes inspiration from Nature's defense mechanisms that have evolved to allow life to flourish in extreme environments and will employ modern polymer chemistry to apply it to a real clinical problem; cryopreservation.

Publications

List of publications.
year	authors and title	journal	last update
2019	Daniel E. Mitchell, Alice E. R. Fayter, Robert C. Deller, Muhammad Hasan, Jose Gutierrez-Marcos, Matthew I. Gibson Ice-recrystallization inhibiting polymers protect proteins against freeze-stress and enable glycerol-free cryostorage published pages: 364-368, ISSN: 2051-6347, DOI: 10.1039/c8mh00727f	Materials Horizons 6/2	2019-08-05
2018	Ruben M. F. TomÃ¡s, Benjamin Martyn, Trisha L. Bailey, Matthew I. Gibson Engineering Cell Surfaces by Covalent Grafting of Synthetic Polymers to Metabolically-Labeled Glycans published pages: 1289-1294, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00675	ACS Macro Letters 7/11	2019-08-05
2019	Christopher Stubbs, Thomas R Congdon, Matthew I. Gibson Photo-polymerisation and study of the ice recrystallisation inhibition of hydrophobically modified poly(vinyl pyrrolidone) co-polymers published pages: 330-336, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2018.11.047	European Polymer Journal 110	2019-08-05
2018	Christopher Stubbs, Laura E. Wilkins, Alice E. R Fayter, Marc Walker, Matthew I. Gibson Multivalent Presentation of Ice Recrystallization Inhibiting Polymers on Nanoparticles Retains Activity published pages: 7347-7353, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b01952	Langmuir 35/23	2019-08-05
2018	Muhammad Hasan, Alice E. R. Fayter, Matthew I. Gibson Ice Recrystallization Inhibiting Polymers Enable Glycerol-Free Cryopreservation of Microorganisms published pages: 3371-3376, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b00660	Biomacromolecules 19/8	2019-08-05
2018	Benjamin Martyn, Caroline I. Biggs, Matthew I. Gibson Comparison of systematically functionalized heterogeneous and homogenous glycopolymers as toxin inhibitors published pages: 40-47, ISSN: 0887-624X, DOI: 10.1002/pola.29279	Journal of Polymer Science Part A: Polymer Chemistry 57/1	2019-08-05
2018	Alice E. R. Fayter, Matthew I. Gibson, Emily R. Draper Sub-zero temperature mechanically stable low molecular weight hydrogels published pages: 7274-7279, ISSN: 2050-7518, DOI: 10.1039/c8tb01668b	Journal of Materials Chemistry B 6/44	2019-08-05
2019	Caroline I. Biggs, Christopher Stubbs, Ben Graham, Alice E. R. Fayter, Muhammad Hasan, Matthew I. Gibson Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer â€œActiveâ€? published pages: 1900082, ISSN: 1616-5187, DOI: 10.1002/mabi.201900082	Macromolecular Bioscience Mater. Horiz., 2019,6, 364-368	2019-08-05
2019	Laura E. Wilkins, Muhammad Hasan, Alice E. R. Fayter, Caroline Biggs, Marc Walker, Matthew I. Gibson Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles published pages: 2986-2990, ISSN: 1759-9954, DOI: 10.1039/c8py01719k	Polymer Chemistry 10/23	2019-08-05
2015	Daniel E. Mitchell, Matthew I. Gibson Latent Ice Recrystallization Inhibition Activity in Nonantifreeze Proteins: Ca 2+ -Activated Plant Lectins and Cation-Activated Antimicrobial Peptides published pages: 3411-3416, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.5b01118	Biomacromolecules 16/10	2019-05-28
2015	Helen R. Thomas, Daniel J. Phillips, Neil R. Wilson, Matthew I. Gibson, Jonathan P. Rourke One-step grafting of polymers to graphene oxide published pages: 8270-8274, ISSN: 1759-9954, DOI: 10.1039/C5PY01358E	Polym. Chem. 6/48	2019-05-28
2017	Lewis D. Blackman, Kay E. B. Doncom, Matthew I. Gibson, Rachel K. O\'Reilly Comparison of photo- and thermally initiated polymerization-induced self-assembly: a lack of end group fidelity drives the formation of higher order morphologies published pages: 2860-2871, ISSN: 1759-9954, DOI: 10.1039/c7py00407a	Polymer Chemistry 8/18	2019-05-28
2017	L. D. Blackman, M. I. Gibson, R. K. O\'Reilly Probing the causes of thermal hysteresis using tunable N agg micelles with linear and brush-like thermoresponsive coronas published pages: 233-244, ISSN: 1759-9954, DOI: 10.1039/C6PY01191H	Polymer Chemistry 8/1	2019-05-28
2018	Ben Graham, Alice E. R. Fayter, Judith E. Houston, Rachel C. Evans, Matthew I. Gibson Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization published pages: 5682-5685, ISSN: 0002-7863, DOI: 10.1021/jacs.8b02066	Journal of the American Chemical Society 140/17	2019-05-28
2016	Sangho Won, Daniel J. Phillips, Marc Walker, Matthew I. Gibson Co-operative transitions of responsive-polymer coated gold nanoparticles; precision tuning and direct evidence for co-operative aggregation published pages: 5673-5682, ISSN: 2050-7518, DOI: 10.1039/C6TB01336H	J. Mater. Chem. B 4/34	2019-05-28
2017	Antonio Laezza, Angela Casillo, Sandro Cosconati, Caroline I. Biggs, Antonio Fabozzi, Luigi Paduano, Alfonso Iadonisi, Ettore Novellino, Matthew I. Gibson, Antonio Randazzo, Maria M. Corsaro, Emiliano Bedini Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity published pages: 2267-2276, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00326	Biomacromolecules 18/8	2019-05-28
2017	Thomas R. Congdon, Rebecca Notman, Matthew I. Gibson Synthesis of star-branched poly(vinyl alcohol) and ice recrystallization inhibition activity published pages: 320-327, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2017.01.039	European Polymer Journal 88	2019-05-28
2016	Christopher Stubbs, Julia Lipecki, Matthew I. Gibson Regioregular Alternating Polyampholytes Have Enhanced Biomimetic Ice Recrystallization Activity Compared to Random Copolymers and the Role of Side Chain versus Main Chain Hydrophobicity published pages: 295-302, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b01691	Biomacromolecules 18/1	2019-05-28
2016	Caroline I. Biggs, Marc Walker, Matthew I. Gibson â€œGrafting toâ€ of RAFTed Responsive Polymers to Glass Substrates by Thiolâ€“Ene and Critical Comparison to Thiolâ€“Gold Coupling published pages: 2626-2633, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b00662	Biomacromolecules 17/8	2019-05-28
2017	Angela Casillo, Ermenegilda Parrilli, Filomena Sannino, Daniel E. Mitchell, Matthew I. Gibson, Gennaro Marino, Rosa Lanzetta, Michelangelo Parrilli, Sandro Cosconati, Ettore Novellino, Antonio Randazzo, Maria L. Tutino, M. Michela Corsaro Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection published pages: 364-371, ISSN: 0144-8617, DOI: 10.1016/j.carbpol.2016.09.037	Carbohydrate Polymers 156	2019-05-28
2017	Ben Graham, Trisha L. Bailey, Joseph R. J. Healey, Moreno Marcellini, Sylvain Deville, Matthew I. Gibson Polyproline as a Minimal Antifreeze Protein Mimic That Enhances the Cryopreservation of Cell Monolayers published pages: 15941-15944, ISSN: 1433-7851, DOI: 10.1002/anie.201706703	Angewandte Chemie International Edition 56/50	2019-05-28
2016	Lucienne Otten, Denise Vlachou, Sarah-Jane Richards, Matthew I. Gibson Glycan heterogeneity on gold nanoparticles increases lectin discrimination capacity in label-free multiplexed bioassays published pages: 4305-4312, ISSN: 0003-2654, DOI: 10.1039/C6AN00549G	The Analyst 141/14	2019-05-28
2015	Thomas Congdon, Bethany T. Dean, James Kasperczak-Wright, Caroline I. Biggs, Rebecca Notman, Matthew I. Gibson Probing the Biomimetic Ice Nucleation Inhibition Activity of Poly(vinyl alcohol) and Comparison to Synthetic and Biological Polymers published pages: 2820-2826, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.5b00774	Biomacromolecules 16/9	2019-05-28
2017	Daniel E. Mitchell, Guy Clarkson, David J. Fox, Rebecca A. Vipond, Peter Scott, Matthew I. Gibson Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity published pages: 9835-9838, ISSN: 0002-7863, DOI: 10.1021/jacs.7b05822	Journal of the American Chemical Society 139/29	2019-05-28
2017	Daniel J. Phillips, James Harrison, Sarah-Jane Richards, Daniel E. Mitchell, Esther Tichauer, Alasdair T. M. Hubbard, Collette Guy, Ian Hands-Portman, Elizabeth Fullam, Matthew I. Gibson Evaluation of the Antimicrobial Activity of Cationic Polymers against Mycobacteria: Toward Antitubercular Macromolecules published pages: 1592-1599, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00210	Biomacromolecules 18/5	2019-05-28
2016	Lucienne Otten, Elizabeth Fullam, Matthew I. Gibson Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile published pages: 341-344, ISSN: 1742-206X, DOI: 10.1039/C5MB00720H	Mol. BioSyst. 12/2	2019-05-28
2017	Angela Casillo, Jonas StÃ¥hle, Ermenegilda Parrilli, Filomena Sannino, Daniel E. Mitchell, Giuseppina Pieretti, Matthew I. Gibson, Gennaro Marino, Rosa Lanzetta, Michelangelo Parrilli, GÃ¶ran Widmalm, Maria L. Tutino, Maria M. Corsaro Erratum to: Structural characterization of an all-aminosugar-containing capsular polysaccharide from Colwellia psychrerythraea 34H published pages: 1389-1389, ISSN: 0003-6072, DOI: 10.1007/s10482-017-0900-0	Antonie van Leeuwenhoek 110/11	2019-05-28
2017	Caroline I. Biggs, Christopher Packer, Steven Hindmarsh, Marc Walker, Neil R. Wilson, Jonathan P. Rourke, Matthew I. Gibson Impact of sequential surface-modification of graphene oxide on ice nucleation published pages: 21929-21932, ISSN: 1463-9076, DOI: 10.1039/C7CP03219F	Physical Chemistry Chemical Physics 19/33	2019-05-28
2017	Lewis D. Blackman, Spyridon Varlas, Maria C. Arno, Alice Fayter, Matthew I. Gibson, Rachel K. Oâ€™Reilly Permeable Protein-Loaded Polymersome Cascade Nanoreactors by Polymerization-Induced Self-Assembly published pages: 1263-1267, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00725	ACS Macro Letters 6/11	2019-05-28
2017	Guillaume Hedir, Christopher Stubbs, Phillip Aston, Andrew P. Dove, Matthew I. Gibson Synthesis of Degradable Poly(vinyl alcohol) by Radical Ring-Opening Copolymerization and Ice Recrystallization Inhibition Activity published pages: 1404-1408, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00905	ACS Macro Letters 6/12	2019-05-28
2016	Daniel E. Mitchell, Joseph R. Lovett, Steven P. Armes, Matthew I. Gibson Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells published pages: 2801-2804, ISSN: 1433-7851, DOI: 10.1002/anie.201511454	Angewandte Chemie International Edition 55/8	2019-05-28
2017	Nicholas S. Vail, Christopher Stubbs, Caroline I. Biggs, Matthew I. Gibson Ultralow Dispersity Poly(vinyl alcohol) Reveals Significant Dispersity Effects on Ice Recrystallization Inhibition Activity published pages: 1001-1004, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00595	ACS Macro Letters 6/9	2019-05-28
2016	Daniel J. Phillips, Thomas R. Congdon, Matthew I. Gibson Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger published pages: 1701-1704, ISSN: 1759-9954, DOI: 10.1039/c5py01948f	Polymer Chemistry 7/9	2019-05-28
2017	Collette S Guy, Esther Tichauer, Gemma L Kay, Daniel J Phillips, Trisha L Bailey, James Harrison, Christopher M Furze, Andrew D Millard, Matthew I Gibson, Mark J Pallen, Elizabeth Fullam Identification of the anti-mycobacterial functional properties of piperidinol derivatives published pages: 2183-2193, ISSN: 0007-1188, DOI: 10.1111/bph.13744	British Journal of Pharmacology 174/14	2019-05-28
2017	Sangho Won, Sarah-Jane Richards, Marc Walker, Matthew I. Gibson Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition published pages: 106-109, ISSN: 2055-6756, DOI: 10.1039/c6nh00202a	Nanoscale Horizons 2/2	2019-05-28
2017	Caroline I. Biggs, Trisha L. Bailey, Ben Graham, Christopher Stubbs, Alice Fayter, Matthew I. Gibson Polymer mimics of biomacromolecular antifreezes published pages: 1546, ISSN: 2041-1723, DOI: 10.1038/s41467-017-01421-7	Nature Communications 8/1	2019-05-28
2018	Sangho Won, Steven Hindmarsh, Matthew I. Gibson Triggerable Multivalent Glyconanoparticles for Probing Carbohydrateâ€“Carbohydrate Interactions published pages: 178-183, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00891	ACS Macro Letters 7/2	2019-05-28
2016	Thomas R. Congdon, Rebecca Notman, Matthew I. Gibson Influence of Block Copolymerization on the Antifreeze Protein Mimetic Ice Recrystallization Inhibition Activity of Poly(vinyl alcohol) published pages: 3033-3039, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b00915	Biomacromolecules 17/9	2019-05-28
2016	Robert C. Deller, Jeffrey E. Pessin, Manu Vatish, Daniel A. Mitchell, Matthew I. Gibson Enhanced non-vitreous cryopreservation of immortalized and primary cells by ice-growth inhibiting polymers published pages: 1079-1084, ISSN: 2047-4830, DOI: 10.1039/C6BM00129G	Biomater. Sci. 4/7	2019-05-28
2017	Sarah-Jane Richards, Klea Isufi, Laura E. Wilkins, Julia Lipecki, Elizabeth Fullam, Matthew I. Gibson Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms published pages: 256-264, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01561	Biomacromolecules 19/1	2019-05-28
2018	Lewis D. Blackman, Spyridon Varlas, Maria C. Arno, Zachary H. Houston, Nicholas L. Fletcher, Kristofer J. Thurecht, Muhammad Hasan, Matthew I. Gibson, Rachel K. Oâ€™Reilly Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility published pages: 718-723, ISSN: 2374-7943, DOI: 10.1021/acscentsci.8b00168	ACS Central Science 4/6	2019-03-11

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