Explore the words cloud of the ELASTISLET project. It provides you a very rough idea of what is the project "ELASTISLET" about.
The following table provides information about the project.
Coordinator |
UNIVERSIDAD DE VALLADOLID
Organization address contact info |
Coordinator Country | Spain [ES] |
Project website | http://www.elastislet.eu/en/ |
Total cost | 6˙214˙495 € |
EC max contribution | 6˙214˙495 € (100%) |
Programme |
1. H2020-EU.2.1.3.1. (Cross-cutting and enabling materials technologies) |
Code Call | H2020-NMP-2014-two-stage |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-06-01 to 2019-05-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | UNIVERSIDAD DE VALLADOLID | ES (VALLADOLID) | coordinator | 1˙773˙555.00 |
2 | UPPSALA UNIVERSITET | SE (UPPSALA) | participant | 831˙597.00 |
3 | UNIVERSITA DEGLI STUDI DI PERUGIA | IT (PERUGIA) | participant | 688˙579.00 |
4 | MEDIZINISCHE UNIVERSITAET WIEN | AT (WIEN) | participant | 645˙750.00 |
5 | TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL | ES (VALLADOLID) | participant | 489˙000.00 |
6 | UNIVERSIDADE DE AVEIRO | PT (AVEIRO) | participant | 354˙940.00 |
7 | NCARDIA AG | DE (KOLN) | participant | 341˙875.00 |
8 | THE HEBREW UNIVERSITY OF JERUSALEM | IL (JERUSALEM) | participant | 303˙125.00 |
9 | UNIVERSIDADE DO MINHO | PT (BRAGA) | participant | 301˙121.00 |
10 | Promoscience srl | IT (TRIESTE) | participant | 262˙450.00 |
11 | ASPHALION SL | ES (BARCELONA) | participant | 222˙500.00 |
12 | UNIVERSITAT BASEL | CH (BASEL) | participant | 0.00 |
ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial design, production and processing, cross-linking/grafting technology and cell therapy, to synergistically integrate them into a new immune-isolation and biomimetic scaffolding approach for islet and cell transplantation in diabetes treatment. ELASTISLET’s starting point is a highly innovative and versatile family of superior biomaterials, the Elastin-like Recombinamers (ELRs). Those innovative materials will be combined with the most cutting-edge encapsulation technologies, such as reactive LbL. ELASTISLET relies on the most innovative ideas taken from synthetic biology, nanobiotechnology and molecular and cellular biology to build the ideal niche for islet/cell encapsulation and transplantation. ELASTISLET main objective is to achieve a functional coating that fulfils, first, the basic requirements of optimal biocompatibility and physical properties (permselectivity) but, second, generate a capsule that can promote an intense and directed cross talk through all cell-material interfaces involved: the implant-surrounding tissue (outer) interface and cargo cells-capsule (inner) interface. At the end, a capsule that is able not only to cloak its content and isolate it from the immune rejection but that it is able to biologically interact with the surrounding tissues and its cargo simultaneously in a way that the implanted capsule will immediately interact and fuse with the surrounding tissues creating a real continuity of the extracellular matrix from the core of the capsule to the surrounding hosts tissues and procuring adequate nutrient supply. That will provide a physiologically ideal biomimetic environment for the implanted islets/cells to survive and function in the long term without perceiving a foreign, unusual or hostile environment.
Report on existing standards and standardization landscape | Documents, reports | 2020-03-05 08:32:04 |
Project website | Websites, patent fillings, videos etc. | 2020-03-05 08:32:04 |
Report and management activities | Documents, reports | 2020-03-05 08:32:04 |
Communication and dissemination plan | Documents, reports | 2020-03-05 08:32:04 |
Quality and contingency | Documents, reports | 2020-03-05 08:32:04 |
Take a look to the deliverables list in detail: detailed list of ELASTISLET deliverables.
year | authors and title | journal | last update |
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2019 |
Luis Quintanilla-Sierra, Carmen GarcÃa-Arévalo, J.C. Rodriguez-Cabello Self-assembly in Elastin-Like Recombinamers: a Mechanism to Mimic Natural Complexity published pages: 100007, ISSN: 2590-0064, DOI: 10.1016/j.mtbio.2019.100007 |
Materials Today Bio | 2020-03-05 |
2019 |
Juan Gonzalez-Valdivieso, Alessandra Girotti, Raquel Muñoz, J. Carlos Rodriguez-Cabello, F. Javier Arias Self-Assembling ELR-Based Nanoparticles as Smart Drug-Delivery Systems Modulating Cellular Growth via Akt published pages: 1996-2007, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b00206 |
Biomacromolecules 20/5 | 2020-03-05 |
2019 |
Leander Poocza, Filippo Cipriani, Matilde Alonso, José Carlos RodrÃguez-Cabello Hydrophobic Cholesteryl Moieties Trigger Substrate Cell–Membrane Interaction of Elastin–Mimetic Protein Coatings in Vitro published pages: 10818-10827, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b00548 |
ACS Omega 4/6 | 2020-03-05 |
2019 |
Tatjana Flora, I González de Torre, M Alonso, J Carlos RodrÃguez-Cabello Use of proteolytic sequences with different cleavage kinetics as a way to generate hydrogels with preprogrammed cell-infiltration patterns imparted over their given 3D spatial structure published pages: 35008, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab10a5 |
Biofabrication 11/3 | 2020-03-05 |
2018 |
Roni Lehmann-Werman, Judith Magenheim, Joshua Moss, Daniel Neiman, Ofri Abraham, Sheina Piyanzin, Hai Zemmour, Ilana Fox, Talya Dor, Markus Grompe, Giora Landesberg, Bao-Li Loza, Abraham Shaked, Kim Olthoff, Benjamin Glaser, Ruth Shemer, Yuval Dor Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.120687 |
JCI Insight 3/12 | 2020-03-05 |
2018 |
M Putzu, F Causa, Manuel Parente, Israel González de Torre, J C Rodriguez-Cabello, P A Netti Silk-ELR co-recombinamer covered stents obtained by electrospinning published pages: 21-28, ISSN: 2056-3418, DOI: 10.1093/rb/rby022 |
Regenerative Biomaterials 6/1 | 2020-03-05 |
2019 |
Ana M. Testera, Mercedes Santos, Alessandra Girotti, F. Javier Arias, J. Manuel Báñez, Matilde Alonso, J. Carlos RodrÃguez-Cabello A novel lipase-catalyzed method for preparing ELR-based bioconjugates published pages: 752-759, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2018.10.028 |
International Journal of Biological Macromolecules 121 | 2020-03-05 |
2016 |
Mariana B. Oliveira, Javad Hatami, João F. Mano Coating Strategies Using Layer-by-layer Deposition for Cell Encapsulation published pages: 1753-1764, ISSN: 1861-4728, DOI: 10.1002/asia.201600145 |
Chemistry - An Asian Journal 11/12 | 2020-03-05 |
2018 |
Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L. Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, A. M. James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease published pages: 1-12, ISSN: 2041-1723, DOI: 10.1038/s41467-018-07466-6 |
Nature Communications 9/1 | 2020-03-05 |
2019 |
Rui R. Costa, Diana Soares da Costa, Rui L. Reis, Iva Pashkuleva Bioinspired baroplastic glycosaminoglycan sealants for soft tissues published pages: 108-117, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.01.040 |
Acta Biomaterialia 87 | 2020-03-05 |
2019 |
Tatjana Flora, I. González de Torre, M. Alonso, J. Carlos RodrÃguez-Cabello Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels published pages: , ISSN: 0957-4530, DOI: 10.1007/s10856-019-6232-z |
Journal of Materials Science: Materials in Medicine 30/2 | 2020-03-05 |
2018 |
Tatjana Flora, I. González de Torre, Luis Quintanilla, M. Alonso, J. Carlos RodrÃguez-Cabello Spatial control and cell adhesion selectivity on model gold surfaces grafted with elastin-like recombinamers published pages: 19-29, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2018.06.026 |
European Polymer Journal 106 | 2020-03-05 |
2018 |
Hai Zemmour, David Planer, Judith Magenheim, Joshua Moss, Daniel Neiman, Dan Gilon, Amit Korach, Benjamin Glaser, Ruth Shemer, Giora Landesberg, Yuval Dor Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03961-y |
Nature Communications 9/1 | 2020-03-05 |
2019 |
Filippo Cipriani, Dominik Bernhagen, Carmen GarcÃa-Arévalo, Israel González de Torre, Peter Timmerman, José Carlos RodrÃguez-Cabello Bicyclic RGD peptides with high integrin α v β 3 and α 5 β 1 affinity promote cell adhesion on elastin-like recombinamers published pages: 35009, ISSN: 1748-605X, DOI: 10.1088/1748-605x/aafd83 |
Biomedical Materials 14/3 | 2020-03-05 |
2018 |
Mercedes Santos, Sofia Serrano-Ducar, Juan Gonzalez-Valdivieso, Reinaldo Vallejo, Alessandra Girotti, Purificacion Cuadrado, Francisco Javier Arias Genetically Engineered Elastin-based Biomaterials for Biomedical Applications published pages: 1-28, ISSN: 0929-8673, DOI: 10.2174/0929867325666180508094637 |
Current Medicinal Chemistry 25 | 2020-03-05 |
2017 |
Javad Hatami, Sandra Silva, Mariana Oliveira, Rui Costa, Rui Reis, João Mano Multilayered Films Produced by Layer-by-Layer Assembly of Chitosan and Alginate as a Potential Platform for the Formation of Human Adipose-Derived Stem Cell aggregates published pages: 440, ISSN: 2073-4360, DOI: 10.3390/polym9090440 |
Polymers 9/12 | 2020-03-05 |
2016 |
Mercedes Vila, Ana GarcÃa, Alessandra Girotti, Matilde Alonso, Jose Carlos RodrÃguez-Cabello, Arlyng González-Vázquez, Josep A. Planell, Elisabeth Engel, Julia Buján, Natalio GarcÃa-Honduvilla, MarÃa Vallet-Regà 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine published pages: 349-356, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.09.016 |
Acta Biomaterialia 45 | 2020-03-05 |
2019 |
Constancio Gonzalez-Obeso, Alessandra Girotti, J. Carlos Rodriguez-Cabello A transferrin receptor-binding mucoadhesive elastin-like recombinamer: In vitro and in vivo characterization published pages: 241-250, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.02.027 |
Acta Biomaterialia 88 | 2020-03-05 |
2015 |
Karla E. Inostroza-Brito, Estelle Collin, Orit Siton-Mendelson, Katherine H. Smith, Amà lia Monge-Marcet, Daniela S. Ferreira, Raúl Pérez RodrÃguez, Matilde Alonso, José Carlos RodrÃguez-Cabello, Rui L. Reis, Francesc Sagués, Lorenzo Botto, Ronit Bitton, Helena S. Azevedo, Alvaro Mata Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system published pages: 897-904, ISSN: 1755-4330, DOI: 10.1038/nchem.2349 |
Nature Chemistry 7/11 | 2020-03-05 |
2018 |
Israel González de Torre, Arturo Ibáñez-Fonseca, Luis Quintanilla, Matilde Alonso, José-Carlos RodrÃguez-Cabello Random and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineering published pages: 137-149, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.03.027 |
Acta Biomaterialia 72 | 2020-03-05 |
2017 |
Yuping Li, Jose Carlos Rodriguez-Cabello, Conrado Aparicio Intrafibrillar Mineralization of Self-Assembled Elastin-Like Recombinamer Fibrils published pages: 5838-5846, ISSN: 1944-8244, DOI: 10.1021/acsami.6b15285 |
ACS Applied Materials & Interfaces 9/7 | 2020-03-05 |
2017 |
Jeevan Govindharajulu, Xi Chen, Yuping Li, Jose Rodriguez-Cabello, Mrinal Battacharya, Conrado Aparicio Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants published pages: 369, ISSN: 1422-0067, DOI: 10.3390/ijms18020369 |
International Journal of Molecular Sciences 18/2 | 2020-03-05 |
2017 |
Sebastian Manuel Staubli, Giulia Cerino, Israel Gonzalez De Torre, Matilde Alonso, Daniel Oertli, Friedrich Eckstein, Katharina Glatz, José Carlos RodrÃguez Cabello, Anna Marsano Control of angiogenesis and host response by modulating the cell adhesion properties of an Elastin-Like Recombinamer-based hydrogel published pages: 30-41, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.04.047 |
Biomaterials 135 | 2020-03-05 |
2018 |
J. Carlos RodrÃguez-Cabello, I. González de Torre, A. Ibañez-Fonseca, M. Alonso Bioactive scaffolds based on elastin-like materials for wound healing published pages: 118-133, ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.03.003 |
Advanced Drug Delivery Reviews 129 | 2020-03-05 |
2017 |
David Pescador, Arturo Ibáñez-Fonseca, FermÃn Sánchez-Guijo, Jesús G. Briñón, Francisco Javier Arias, Sandra Muntión, Cristina Hernández, Alessandra Girotti, Matilde Alonso, MarÃa Consuelo del Cañizo, José Carlos RodrÃguez-Cabello, Juan Francisco Blanco Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels published pages: 115, ISSN: 0957-4530, DOI: 10.1007/s10856-017-5928-1 |
Journal of Materials Science: Materials in Medicine 28/8 | 2020-03-05 |
2017 |
Esen Sayin, Rosti Hama Rashid, José Carlos RodrÃguez-Cabello, Ahmed Elsheikh, Erkan Türker Baran, Vasif Hasirci Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend published pages: 71-81, ISSN: 2452-199X, DOI: 10.1016/j.bioactmat.2017.04.001 |
Bioactive Materials 2/2 | 2020-03-05 |
2018 |
Boris L. Gala-Lopez, Daniel Neiman, Tatsuya Kin, Doug O’Gorman, Andrew R. Pepper, Andrew J. Malcolm, Sheina Pianzin, Peter A. Senior, Patricia Campbell, Benjamin Glaser, Yuval Dor, Ruth Shemer, A.M. James Shapiro Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation published pages: 978-985, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000002083 |
Transplantation 102/6 | 2020-03-05 |
2017 |
Karla E. Inostroza-Brito, Estelle C. Collin, Anna Majkowska, Sherif Elsharkawy, Alistair Rice, Armando E. del RÃo Hernández, Xin Xiao, José RodrÃguez-Cabello, Alvaro Mata Cross-linking of a biopolymer-peptide co-assembling system published pages: 80-89, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.05.043 |
Acta Biomaterialia 58 | 2020-03-05 |
2018 |
Rui R. Costa, Miguel González-Pérez, Marcos Herrero-Gutiérrez, Ricardo A. Pires, Matilde Alonso, J. Carlos Rodriguez-Cabello, Rui L. Reis, Iva Pashkuleva Tuning the stiffness of surfaces by assembling genetically engineered polypeptides with tailored amino acid sequence published pages: , ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b00723 |
Biomacromolecules | 2020-03-05 |
2017 |
Maria P. Sousa, Israel Gonzalez de Torre, Mariana B. Oliveira, José C. RodrÃguez-Cabello, João F. Mano Biomimetic click assembled multilayer coatings exhibiting responsive properties published pages: 150-163, ISSN: 2468-5194, DOI: 10.1016/j.mtchem.2017.04.001 |
Materials Today Chemistry 4 | 2020-03-05 |
2018 |
Sherif Elsharkawy, Maisoon Al-Jawad, Maria F. Pantano, Esther Tejeda-Montes, Khushbu Mehta, Hasan Jamal, Shweta Agarwal, Kseniya Shuturminska, Alistair Rice, Nadezda V. Tarakina, Rory M. Wilson, Andy J. Bushby, Matilde Alonso, Jose C. Rodriguez-Cabello, Ettore Barbieri, Armando del RÃo Hernández, Molly M. Stevens, Nicola M. Pugno, Paul Anderson, Alvaro Mata Protein disorder–order interplay to guide the growth of hierarchical mineralized structures published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04319-0 |
Nature Communications 9/1 | 2020-03-05 |
2018 |
Arturo Ibáñez-Fonseca, Teresa L. Ramos, Israel González de Torre, Luis Ignacio Sánchez-Abarca, Sandra Muntión, Francisco Javier Arias, MarÃa Consuelo del Cañizo, Matilde Alonso, FermÃn Sánchez-Guijo, José Carlos RodrÃguez-Cabello Biocompatibility of two model elastin-like recombinamer-based hydrogels formed through physical or chemical cross-linking for various applications in tissue engineering and regenerative medicine published pages: e1450-e1460, ISSN: 1932-6254, DOI: 10.1002/term.2562 |
Journal of Tissue Engineering and Regenerative Medicine 12/3 | 2020-03-05 |
2018 |
Alicia Fernández-Colino, Frederic Wolf, Hans Keijdener, Stephan Rütten, Thomas Schmitz-Rode, Stefan Jockenhoevel, J. Carlos RodrÃguez-Cabello, Petra Mela Macroporous click-elastin-like hydrogels for tissue engineering applications published pages: 140-147, ISSN: 0928-4931, DOI: 10.1016/j.msec.2018.03.013 |
Materials Science and Engineering: C 88 | 2020-03-05 |
2018 |
Ayse Selcen Alagoz, Jose Carlos Rodriguez-Cabello, Vasif Hasirci PHBV wet spun scaffold coated with ELR-REDV improves vascularization for bone tissue engineering published pages: , ISSN: 1748-6041, DOI: 10.1088/1748-605X/aad139 |
Biomedical Materials | 2020-03-05 |
2016 |
Erik Korsgren, Olle Korsgren Glucose Effectiveness published pages: 111-115, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000000900 |
Transplantation 100/1 | 2020-03-05 |
2017 |
Mohamed Hamed Misbah, Mercedes Santos, Luis Quintanilla, Christina Günter, Matilde Alonso, Andreas Taubert, José Carlos RodrÃguez-Cabello Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization published pages: 772-783, ISSN: 2190-4286, DOI: 10.3762/bjnano.8.80 |
Beilstein Journal of Nanotechnology 8 | 2020-03-05 |
2018 |
Per-Ola Carlsson, Daniel Espes, Amir Sedigh, Avi Rotem, Baruch Zimerman, Helena Grinberg, Tali Goldman, Uriel Barkai, Yuval Avni, Gunilla T. Westermark, Lina Carlbom, Håkan Ahlström, Olof Eriksson, Johan Olerud, Olle Korsgren Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus published pages: 1735-1744, ISSN: 1600-6135, DOI: 10.1111/ajt.14642 |
American Journal of Transplantation 18/7 | 2020-03-05 |
2017 |
Arturo Ibáñez-Fonseca, Matilde Alonso, Francisco Javier Arias, José Carlos RodrÃguez-Cabello Förster Resonance Energy Transfer-Paired Hydrogel Forming Silk-Elastin-Like Recombinamers by Recombinant Conjugation of Fluorescent Proteins published pages: 828-835, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00738 |
Bioconjugate Chemistry 28/3 | 2020-03-05 |
2017 |
Olle Korsgren Islet Encapsulation: Physiological Possibilities and Limitations published pages: 1748-1754, ISSN: 0012-1797, DOI: 10.2337/db17-0065 |
Diabetes 66/7 | 2020-03-05 |
2017 |
Andrea Grosso, Maximilian G. Burger, Alexander Lunger, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration published pages: 68, ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00068 |
Frontiers in Bioengineering and Biotechnology 5 | 2020-03-05 |
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The information about "ELASTISLET" are provided by the European Opendata Portal: CORDIS opendata.
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