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LONGHEART SIGNED

Exploring selected long non-coding RNAs as diagnostics and therapeutic targets for heart failure

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LONGHEART project word cloud

Explore the words cloud of the LONGHEART project. It provides you a very rough idea of what is the project "LONGHEART" about.

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Project "LONGHEART" data sheet

The following table provides information about the project.

Coordinator	MEDIZINISCHE HOCHSCHULE HANNOVER Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 website: www.mh-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	1˙816˙250 €
EC max contribution	1˙816˙250 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MEDIZINISCHE HOCHSCHULE HANNOVER MEDIZINISCHE HOCHSCHULE HANNOVER Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 website: www.mh-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	coordinator	1˙816˙250.00

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Project objective

Despite clinical advances, diseases of the cardiovascular system are the most common cause of morbidity and mortality in the EU with currently 50 million people suffering from heart failure. These important challenges call for a better understanding of underlying mechanisms to enable development of innovative, effective diagnostic and therapeutic strategies for heart failure. Cardiac stress such as myocardial infarction or hypertension leads to cellular “remodeling” of the left ventricle resulting in heart failure. Protein-coding genes originate from only 1.5% of the genome, whereas the larger remaining portion is often transcribed to non-coding RNAs, of which functional importance is still ill understood. We pioneered a role of small microRNAs as diagnostics and therapeutic targets for heart failure (Nature, 2008; Nature Comm, 2012, J Clin Invest, 2014). We now will focus on the larger fraction of long non-coding RNAs (lncRNAs) and their functional roles, as well as diagnostic and therapeutic use in heart failure. The proposal has the following interconnected objectives: a) identify novel functional relevant cardiac remodeling-associated lncRNAs; b) characterise key lncRNA cardiac targetomes; c) investigate lncRNA-paracrine mechanisms and the diagnostic and prognostic potential of cardiac-derived extracellular lncRNAs using large clinical cohorts; and d) discover their therapeutic potential to prevent cardiac remodeling in clinically relevant animal models. Innovative molecular and cell-based methods, a unique lncRNA-shRNA library, genetic animal models and availability of large clinical biobanks will form the basis for a successful strategy. LONGHEART will lead to ground-breaking new insight into the role of lncRNAs in the heart. These findings will firmly establish lncRNA-based mechanisms to identify fundamentally novel diagnostic and therapeutic entry points for a most serious clinical important disorder in dire need for new diagnostic and therapeutic paradigms.

Publications

List of publications.
year	authors and title	journal	last update
2017	Christian BÃ¤r, Thomas Thum Changing Direction published pages: 1393-1395, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.310316	Circulation Research 120/9	2019-06-06
2015	Sandra C. Mayer, Ralf Gilsbach, Sebastian Preissl, Elsa Beatriz Monroy Ordonez, Tilman Schnick, Nadine Beetz, Achim Lother, Carolin Rommel, Hannah Ihle, Heiko Bugger, Frank RÃ¼hle, Andrea Schrepper, Michael Schwarzer, Claudia Heilmann, Ulrike BÃ¶nisch, Shashi Kumar Gupta, Jochen Wilpert, Oliver Kretz, Dominik von Elverfeldt, Joachim Orth, Klaus Aktories, Friedhelm Beyersdorf, Christoph Bode, Brigitte Stiller, Markus KrÃ¼ger, Thomas Thum, Torsten Doenst, Monika Stoll, Lutz Hein Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart FailureNovelty and Significance published pages: 622-633, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.115.306721	Circulation Research 117/7	2019-06-06
2017	Maria-Teresa Piccoli, Shashi Kumar Gupta, Janika Viereck, Ariana Foinquinos, Sabine Samolovac, Freya Luise Kramer, Ankita Garg, Janet Remke, Karina Zimmer, Sandor Batkai, Thomas Thum Inhibition of the Cardiac Fibroblastâ€“Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic DysfunctionNovelty and Significance published pages: 575-583, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.310624	Circulation Research 121/5	2019-06-06
2017	Janika Viereck, Thomas Thum Long Noncoding RNAs in Pathological Cardiac Remodeling published pages: 262-264, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.310174	Circulation Research 120/2	2019-06-06
2017	Serge Masson, Sandor Batkai, Julia Beermann, Christian BÃ¤r, Angelika Pfanne, Sabrina Thum, Michela Magnoli, Giovanna Balconi, Gian Luigi Nicolosi, Luigi Tavazzi, Roberto Latini, Thomas Thum Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.961	European Journal of Heart Failure	2019-06-06
2017	Ke Xiao, Thomas Thum Exosomal MicroRNAs Released by Pediatric Cardiac Progenitor Cells published pages: 607-609, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.310443	Circulation Research 120/4	2019-06-06
2017	Cinzia Perrino, Albert-LaszlÃ³ BarabÃ¡si, Gianluigi Condorelli, Sean Michael Davidson, Leon De Windt, Stefanie Dimmeler, Felix Benedikt Engel, Derek John Hausenloy, Joseph Addison Hill, Linda Wilhelmina Van Laake, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Manuel Mayr, Fabrice Prunier, Joost Petrus Geradus Sluijter, Rainer Schulz, Thomas Thum, Kirsti Ytrehus, PÃ©ter Ferdinandy Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart published pages: 725-736, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx070	Cardiovascular Research 113/7	2019-06-06
2016	Christian BÃ¤r, Shambhabi Chatterjee, Thomas Thum Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy published pages: 1484-1499, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.116.023686	Circulation 134/19	2019-06-06
2017	A. BÃ¼hrke, C. BÃ¤r, T. Thum Nichtkodierende RNA published pages: , ISSN: 0340-9937, DOI: 10.1007/s00059-017-4660-4	Herz	2019-06-06
2018	Shashi Kumar Gupta, Ankita Garg, Christian BÃ¤r, Shambhabi Chatterjee, Ariana Foinquinos, Hendrik Milting, Katrin StreckfuÃŸ-BÃ¶meke, Jan Fiedler, Thomas Thum Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA ExpressionNovelty and Significance published pages: 246-254, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.311335	Circulation Research 122/2	2019-06-06
2016	Shashi Kumar Gupta, Ariana Foinquinos, Sabrina Thum, Janet Remke, Karina Zimmer, Christophe Bauters, Pascal de Groote, Reinier A. Boon, Leon J. de Windt, Sebastian Preissl, Lutz Hein, Sandor Batkai, Florence Pinet, Thomas Thum Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction published pages: 1557-1571, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.07.739	Journal of the American College of Cardiology 68/14	2019-06-06
2017	Janika Viereck, Thomas Thum Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury published pages: 381-399, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.308434	Circulation Research 120/2	2019-06-06
2016	Maria-Teresa Piccoli, Christian BÃ¤r, Thomas Thum Non-coding RNAs as modulators of the cardiac fibroblast phenotype published pages: 75-81, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2015.12.023	Journal of Molecular and Cellular Cardiology 92	2019-06-06
2016	J. Viereck, R. Kumarswamy, A. Foinquinos, K. Xiao, P. Avramopoulos, M. Kunz, M. Dittrich, T. Maetzig, K. Zimmer, J. Remke, A. Just, J. Fendrich, K. Scherf, E. Bolesani, A. Schambach, F. Weidemann, R. Zweigerdt, L. J. de Windt, S. Engelhardt, T. Dandekar, S. Batkai, T. Thum Long noncoding RNA Chast promotes cardiac remodeling published pages: 326ra22-326ra22, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aaf1475	Science Translational Medicine 8/326	2019-06-06
2017	Yvan Devaux, Esther E. Creemers, Reinier A. Boon, Stanislas Werfel, Thomas Thum, Stefan Engelhardt, Stefanie Dimmeler, Iain Squire Circular RNAs in heart failure published pages: 701-709, ISSN: 1388-9842, DOI: 10.1002/ejhf.801	European Journal of Heart Failure 19/6	2019-06-06
2016	David de Gonzalo-Calvo, Franziska Kenneweg, Claudia Bang, RocÃo Toro, Rutger W. van der Meer, Luuk J. Rijzewijk, Johannes W.A. Smit, Hildo J. Lamb, Vicenta Llorente-Cortes, Thomas Thum Circulating Long Noncoding RNAs in Personalized Medicine published pages: 2914-2916, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.10.014	Journal of the American College of Cardiology 68/25	2019-06-06
2017	Julia Beermann, Dominique Kirste, Katharina Iwanov, Dongchao Lu, Felix KleemiÃŸ, Regalla Kumarswamy, Katharina Schimmel, Christian BÃ¤r, Thomas Thum A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation published pages: 307-318, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.158	Cell Death and Differentiation 25/2	2019-06-06
2017	Yassine Sassi, Petros Avramopoulos, Deepak Ramanujam, Laurenz GrÃ¼ter, Stanislas Werfel, Simon Giosele, Andreas-David Brunner, Dena Esfandyari, Aikaterini S. Papadopoulou, Bart De Strooper, Norbert HÃ¼bner, Regalla Kumarswamy, Thomas Thum, Xiaoke Yin, Manuel Mayr, Bernhard Laggerbauer, Stefan Engelhardt Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01737-4	Nature Communications 8/1	2019-06-06
2016	Jan-Marcus Daniel, AndrÃ© Prock, Jochen Dutzmann, Kristina Sonnenschein, Thomas Thum, Johann Bauersachs, Daniel G. Sedding Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima FormationSignificance published pages: 317-327, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.115.305974	Arteriosclerosis, Thrombosis, and Vascular Biology 36/2	2019-06-06
2015	Thomas Thum Antiageing concepts and cardiovascular disease published pages: 3435-3436, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehv412	European Heart Journal 36/48	2019-06-06
2017	Shambhabi Chatterjee, Christian BÃ¤r, Thomas Thum Linc- ing the Noncoding Genome to Heart Function: Beating Hypertrophy published pages: 577-579, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2017.05.007	Trends in Molecular Medicine 23/7	2019-06-06
2016	D. de Gonzalo-Calvo, F. Kenneweg, C. Bang, R. Toro, R. W. van der Meer, L. J. Rijzewijk, J. W. Smit, H. J. Lamb, V. Llorente-Cortes, T. Thum Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes published pages: 37354, ISSN: 2045-2322, DOI: 10.1038/srep37354	Scientific Reports 6	2019-06-06
2016	Shashi Kumar Gupta, Thomas Thum Non-coding RNAs as orchestrators of autophagic processes published pages: 26-30, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2015.11.012	Journal of Molecular and Cellular Cardiology 95	2019-06-06
2016	Javier Barallobre-Barreiro, Shashi K. Gupta, Anna Zoccarato, Rika Kitazume-Taneike, Marika Fava, Xiaoke Yin, Tessa Werner, Marc N. Hirt, Anna Zampetaki, Alessandro Viviano, Mei Chong, Marshall Bern, Antonios Kourliouros, Nieves Domenech, Peter Willeit, Ajay M. Shah, Marjan Jahangiri, Liliana Schaefer, Jens W. Fischer, Renato V. Iozzo, Rosa Viner, Thomas Thum, Joerg Heineke, Antoine Kichler, Kinya Otsu, Manuel Mayr Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial FibrillationClinical Perspective published pages: 817-832, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.115.016423	Circulation 134/11	2019-06-06
2017	Christian BÃ¤r, Thomas Thum A long way for microRNAs to become meaningful prognostic biomarkers published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.1036	European Journal of Heart Failure	2019-06-06
2016	Julia Beermann, Maria-Teresa Piccoli, Janika Viereck, Thomas Thum Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches published pages: 1297-1325, ISSN: 0031-9333, DOI: 10.1152/physrev.00041.2015	Physiological Reviews 96/4	2019-06-06

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