Explore the words cloud of the CONQUER project. It provides you a very rough idea of what is the project "CONQUER" about.
The following table provides information about the project.
Coordinator |
TECHNISCHE UNIVERSITAET GRAZ
Organization address contact info |
Coordinator Country | Austria [AT] |
Project website | http://www.conquer.at |
Total cost | 2˙463˙975 € |
EC max contribution | 2˙463˙975 € (100%) |
Programme |
1. H2020-EU.1.2.1. (FET Open) |
Code Call | H2020-FETOPEN-2014-2015-RIA |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-09-01 to 2018-08-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | TECHNISCHE UNIVERSITAET GRAZ | AT (GRAZ) | coordinator | 1˙231˙250.00 |
2 | UNIVERZA V MARIBORU | SI (MARIBOR) | participant | 584˙125.00 |
3 | UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE | PL (OLSZTYN) | participant | 472˙500.00 |
4 | MEDIZINISCHE UNIVERSITAT GRAZ | AT (GRAZ) | participant | 92˙350.00 |
5 | UMEA UNIVERSITET | SE (UMEA) | participant | 83˙750.00 |
The ageing society and demographic change is one of the major challenges which Europe is facing now, and even more so in the future. Mastering this challenge requires radically new diagnostic and therapeutic treatments as key factors in achieving the healthy well-being of European citizens. Molecular imaging (MI) plays a pivotal role in diagnosis, understanding of disease and in the development of effective treatments. CONQUER will explore a fundamentally new contrast mechanism with the potential to push magnetic resonance imaging (MRI) far beyond its limits towards a powerful MI modality. This will be achieved by exploiting the cross relaxation between 1H and large quadrupolar nuclei (QN) for contrast agent (CA) design. The main objective is to synthesize bio-compatible QN compounds and nano-particles (NPs), high efficiency and manifold degrees of freedom in the design of smart properties, such as the ability to switch the contrast on and off by changing the magnetic field or chemical binding (e.g. targeting). The NPs will be tailored based on quantum-mechanical simulations. Sensitivity and contrast switching will be demonstrated with MRI in cell cultures. This highly interdisciplinary project combines expertise in quantum physics, chemical and biomedical engineering, material characterisation as well as nanotoxicology. Today, European scientists and companies are already leading global players in CA development. CONQUER will significantly fertilise this field and lay the scientific foundations for a new technology by providing theoretical groundwork, synthesis guidelines, imaging instrumentation and toxicological references. These results will be actively transferred to academia and industry as well in order to strengthen European competitiveness. The combination of a so far unexploited quantum-mechanical phenomenon and cutting-edge imaging technologies has the potential to create MI solutions with significant impact.
Extended quantum-mechanical model | Documents, reports | 2019-05-31 15:08:11 |
Relaxometry data base tuned NPs | Documents, reports | 2019-05-31 15:08:09 |
ZF-NQRS database | Documents, reports | 2019-05-31 11:36:34 |
Relaxometry database prototyping | Documents, reports | 2019-05-31 15:08:10 |
Report on publications and events | Documents, reports | 2019-05-31 10:17:38 |
Cytotoxicity, uptake, inflammation | Documents, reports | 2019-05-31 10:18:10 |
Dextran based NPs characterised | Documents, reports | 2019-05-31 10:17:46 |
Modified MRI scanner characterised | Documents, reports | 2019-05-31 10:17:39 |
Tuned NPs characterised | Documents, reports | 2019-05-31 10:17:36 |
Scientific papers of reporting period 2 | Documents, reports | 2019-05-31 15:08:11 |
Data management plan | Open Research Data Pilot | 2019-05-31 15:08:09 |
Evaluation of NQR-CR with MRI | Documents, reports | 2019-05-31 10:18:02 |
Scientific papers of reporting period 1 | Documents, reports | 2019-05-31 15:03:32 |
Quantum-mechanical model 1 | Documents, reports | 2019-05-31 15:03:36 |
NQR-CR polymers characterised | Documents, reports | 2019-05-30 18:57:02 |
Webpage with open access database | Other | 2019-05-31 15:03:33 |
Take a look to the deliverables list in detail: detailed list of CONQUER deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Markus Bödenler, Ludovic de Rochefort, P. James Ross, Nicolas Chanet, Geneviève Guillot, Gareth R. Davies, Christian Gösweiner, Hermann Scharfetter, David J. Lurie, Lionel M. Broche Comparison of fast field-cycling magnetic resonance imaging methods and future perspectives published pages: 832-848, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1557349 |
Molecular Physics 117/7-8 | 2019-05-22 |
2018 |
Mojca BožiÄ, Thomas Elschner, Doris TkauÄiÄ, Matej BraÄiÄ, Silvo Hribernik, Karin Stana Kleinschek, Rupert Kargl Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method published pages: 6901-6922, ISSN: 0969-0239, DOI: 10.1007/s10570-018-2062-2 |
Cellulose 25/12 | 2019-05-22 |
2018 |
Danuta Kruk, Elzbieta Masiewicz, Evrim Umut, Martin Schlögl, Roland Fischer, Hermann Scharfetter Quadrupole relaxation enhancement and polarisation transfer in DMSO solution of [Bi(NO 3 ) 3 (H 2 O) 3 ]*18-crown-6 in solid state published pages: 944-951, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1552798 |
Molecular Physics 117/7-8 | 2019-05-22 |
2018 |
D. Kruk, E. Umut, E. Masiewicz, C. Sampl, R. Fischer, S. Spirk, C. Goesweiner, H. Scharfetter 209 Bi quadrupole relaxation enhancement in solids as a step towards new contrast mechanisms in magnetic resonance imaging published pages: 12710-12718, ISSN: 1463-9076, DOI: 10.1039/c8cp00993g |
Physical Chemistry Chemical Physics 20/18 | 2019-04-18 |
2018 |
Christian Gösweiner, Perttu Lantto, Roland Fischer, Carina Sampl, Evrim Umut, Per-Olof Westlund, Danuta Kruk, Markus Bödenler, Stefan Spirk, Andreas PetroviÄ, Hermann Scharfetter Tuning Nuclear Quadrupole Resonance: A Novel Approach for the Design of Frequency-Selective MRI Contrast Agents published pages: , ISSN: 2160-3308, DOI: 10.1103/PhysRevX.8.021076 |
Physical Review X 8/2 | 2019-04-18 |
2018 |
Christian Gösweiner, Danuta Kruk, Evrim Umut, Elzbieta Masiewicz, Markus Bödenler, Hermann Scharfetter Predicting quadrupole relaxation enhancement peaks in proton R 1 -NMRD profiles in solid Bi-aryl compounds from NQR parameters published pages: 1-11, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1519201 |
Molecular Physics | 2019-04-18 |
2018 |
Hermann Scharfetter, Christian Gösweiner, Paul Josef Krassnig, Carina Sampl, Martin Thonhofer, Roland Fischer, Stefan Spirk, Rupert Kargl, Karin Stana-Kleinschek, Evrim Umut, Danuta Kruk Aspects of structural order in 209 Bi-containing particles for potential MRI contrast agents based on quadrupole enhanced relaxation published pages: 1-9, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1511869 |
Molecular Physics | 2019-04-18 |
2018 |
Danuta Kruk, Evrim Umut, Elzbieta Masiewicz, Petr Hermann, Hermann Scharfetter 1 H spin–lattice relaxation in water solution of 209 Bi counterparts of Gd 3+ contrast agents published pages: 1-8, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1517907 |
Molecular Physics | 2019-04-18 |
2018 |
Danuta Kruk, Elzbieta Masiewicz, Evrim Umut, Hermann Scharfetter 1 H relaxation and dynamics of triphenylbismuth in deuterated solvents published pages: 1-6, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1513175 |
Molecular Physics | 2019-04-18 |
2018 |
Danuta Kruk, Christian Goesweiner, Elzbieta Masiewicz, Evrim Umut, Carina Sampl, Hermann Scharfetter Model – free approach to quadrupole spin relaxation in solid 209 Bi-aryl compounds published pages: 23414-23423, ISSN: 1463-9076, DOI: 10.1039/C8CP03848A |
Physical Chemistry Chemical Physics 20/36 | 2019-04-18 |
2016 |
Hermann Scharfetter An electronically tuned wideband probehead for NQR spectroscopy in the VHF range published pages: 90-98, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2016.08.008 |
Journal of Magnetic Resonance 271 | 2019-02-20 |
2016 |
C. Gösweiner; R. Fischer; M. Schlögl; D. Kruk; A. Petrovic; S. Spirk; H. Scharfetter Novel smart MRI contrast agents based on nuclear quadrupole cross relaxation – pre-selection of promising compounds published pages: 247–400, ISSN: 0968-5243, DOI: 10.5281/zenodo.159270 |
Magnetic Resonance Materials in Physics, Biology and Medicine ESMRMB Congress, September 2016 | 2019-02-20 |
2016 |
BožiÄ Mojca, BraÄiÄ Matej, Doris TkauÄiÄ, Silvo Hribernik, Manja KureÄiÄ, Kargl Rupert, Spirk Stefan, Mohan Tamilselvan, Stana-Kleinschek Karin NOVEL POLYSACCHARIDE-BASED NANOPARTICLES AND THEIR POTENTIAL APPILCATION IN biomedical IMAGING published pages: , ISSN: , DOI: |
2019-02-20 |
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