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CONQUER

Contrast by Quadrupole Enhanced Relaxation

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 CONQUER project word cloud

Explore the words cloud of the CONQUER project. It provides you a very rough idea of what is the project "CONQUER" about.

fertilise    quantum    toxicological    mechanical    switch    qn    transferred    society    biomedical    demographic    efficiency    nano    interdisciplinary    players    ca    mechanism    nuclei    global    magnetic    ageing    smart    degrees    synthesize    switching    bio    1h    limits    compounds    edge    lay    plays    sensitivity    mri    technologies    engineering    foundations    synthesis    modality    expertise    manifold    groundwork    nanotoxicology    binding    industry    chemical    diagnostic    combines    radically    off    fundamentally    citizens    actively    characterisation    imaging    theoretical    treatments    quadrupolar    disease    molecular    freedom    changing    instrumentation    phenomenon    particles    nps    physics    demonstrated    cultures    healthy    powerful    guidelines    material    simulations    therapeutic    scientists    academia    references    contrast    solutions    push    pivotal    mi    relaxation    scientific    cutting    unexploited    strengthen    significantly    diagnosis    agent    cross    competitiveness    create    mastering    compatible    conquer    cell    resonance    companies    combination    explore   

Project "CONQUER" data sheet

The following table provides information about the project.

Coordinator		 TECHNISCHE UNIVERSITAET GRAZ 

Organization address
address: RECHBAUERSTRASSE 12
city: GRAZ
postcode: 8010
website: www.tugraz.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Austria [AT]
 Project website http://www.conquer.at
 Total cost 2˙463˙975 €
 EC max contribution 2˙463˙975 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET GRAZ AT (GRAZ) coordinator 1˙231˙250.00
2    UNIVERZA V MARIBORU SI (MARIBOR) participant 584˙125.00
3    UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE PL (OLSZTYN) participant 472˙500.00
4    MEDIZINISCHE UNIVERSITAT GRAZ AT (GRAZ) participant 92˙350.00
5    UMEA UNIVERSITET SE (UMEA) participant 83˙750.00

Map

 Project objective

The ageing society and demographic change is one of the major challenges which Europe is facing now, and even more so in the future. Mastering this challenge requires radically new diagnostic and therapeutic treatments as key factors in achieving the healthy well-being of European citizens. Molecular imaging (MI) plays a pivotal role in diagnosis, understanding of disease and in the development of effective treatments. CONQUER will explore a fundamentally new contrast mechanism with the potential to push magnetic resonance imaging (MRI) far beyond its limits towards a powerful MI modality. This will be achieved by exploiting the cross relaxation between 1H and large quadrupolar nuclei (QN) for contrast agent (CA) design. The main objective is to synthesize bio-compatible QN compounds and nano-particles (NPs), high efficiency and manifold degrees of freedom in the design of smart properties, such as the ability to switch the contrast on and off by changing the magnetic field or chemical binding (e.g. targeting). The NPs will be tailored based on quantum-mechanical simulations. Sensitivity and contrast switching will be demonstrated with MRI in cell cultures. This highly interdisciplinary project combines expertise in quantum physics, chemical and biomedical engineering, material characterisation as well as nanotoxicology. Today, European scientists and companies are already leading global players in CA development. CONQUER will significantly fertilise this field and lay the scientific foundations for a new technology by providing theoretical groundwork, synthesis guidelines, imaging instrumentation and toxicological references. These results will be actively transferred to academia and industry as well in order to strengthen European competitiveness. The combination of a so far unexploited quantum-mechanical phenomenon and cutting-edge imaging technologies has the potential to create MI solutions with significant impact.

 Deliverables

List of deliverables.
Extended quantum-mechanical model Documents, reports 2019-05-31 15:08:11
Relaxometry data base tuned NPs Documents, reports 2019-05-31 15:08:09
ZF-NQRS database Documents, reports 2019-05-31 11:36:34
Relaxometry database prototyping Documents, reports 2019-05-31 15:08:10
Report on publications and events Documents, reports 2019-05-31 10:17:38
Cytotoxicity, uptake, inflammation Documents, reports 2019-05-31 10:18:10
Dextran based NPs characterised Documents, reports 2019-05-31 10:17:46
Modified MRI scanner characterised Documents, reports 2019-05-31 10:17:39
Tuned NPs characterised Documents, reports 2019-05-31 10:17:36
Scientific papers of reporting period 2 Documents, reports 2019-05-31 15:08:11
Data management plan Open Research Data Pilot 2019-05-31 15:08:09
Evaluation of NQR-CR with MRI Documents, reports 2019-05-31 10:18:02
Scientific papers of reporting period 1 Documents, reports 2019-05-31 15:03:32
Quantum-mechanical model 1 Documents, reports 2019-05-31 15:03:36
NQR-CR polymers characterised Documents, reports 2019-05-30 18:57:02
Webpage with open access database Other 2019-05-31 15:03:33

Take a look to the deliverables list in detail:  detailed list of CONQUER deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Markus Bödenler, Ludovic de Rochefort, P. James Ross, Nicolas Chanet, Geneviève Guillot, Gareth R. Davies, Christian Gösweiner, Hermann Scharfetter, David J. Lurie, Lionel M. Broche
Comparison of fast field-cycling magnetic resonance imaging methods and future perspectives
published pages: 832-848, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1557349 		Molecular Physics 117/7-8 2019-05-22
2018 Mojca Božič, Thomas Elschner, Doris Tkaučič, Matej Bračič, Silvo Hribernik, Karin Stana Kleinschek, Rupert Kargl
Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method
published pages: 6901-6922, ISSN: 0969-0239, DOI: 10.1007/s10570-018-2062-2 		Cellulose 25/12 2019-05-22
2018 Danuta Kruk, Elzbieta Masiewicz, Evrim Umut, Martin Schlögl, Roland Fischer, Hermann Scharfetter
Quadrupole relaxation enhancement and polarisation transfer in DMSO solution of [Bi(NO 3 ) 3 (H 2 O) 3 ]*18-crown-6 in solid state
published pages: 944-951, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1552798 		Molecular Physics 117/7-8 2019-05-22
2018 D. Kruk, E. Umut, E. Masiewicz, C. Sampl, R. Fischer, S. Spirk, C. Goesweiner, H. Scharfetter
209 Bi quadrupole relaxation enhancement in solids as a step towards new contrast mechanisms in magnetic resonance imaging
published pages: 12710-12718, ISSN: 1463-9076, DOI: 10.1039/c8cp00993g 		Physical Chemistry Chemical Physics 20/18 2019-04-18
2018 Christian Gösweiner, Perttu Lantto, Roland Fischer, Carina Sampl, Evrim Umut, Per-Olof Westlund, Danuta Kruk, Markus Bödenler, Stefan Spirk, Andreas Petrovič, Hermann Scharfetter
Tuning Nuclear Quadrupole Resonance: A Novel Approach for the Design of Frequency-Selective MRI Contrast Agents
published pages: , ISSN: 2160-3308, DOI: 10.1103/PhysRevX.8.021076 		Physical Review X 8/2 2019-04-18
2018 Christian Gösweiner, Danuta Kruk, Evrim Umut, Elzbieta Masiewicz, Markus Bödenler, Hermann Scharfetter
Predicting quadrupole relaxation enhancement peaks in proton R 1 -NMRD profiles in solid Bi-aryl compounds from NQR parameters
published pages: 1-11, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1519201 		Molecular Physics 2019-04-18
2018 Hermann Scharfetter, Christian Gösweiner, Paul Josef Krassnig, Carina Sampl, Martin Thonhofer, Roland Fischer, Stefan Spirk, Rupert Kargl, Karin Stana-Kleinschek, Evrim Umut, Danuta Kruk
Aspects of structural order in 209 Bi-containing particles for potential MRI contrast agents based on quadrupole enhanced relaxation
published pages: 1-9, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1511869 		Molecular Physics 2019-04-18
2018 Danuta Kruk, Evrim Umut, Elzbieta Masiewicz, Petr Hermann, Hermann Scharfetter
1 H spin–lattice relaxation in water solution of 209 Bi counterparts of Gd 3+ contrast agents
published pages: 1-8, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1517907 		Molecular Physics 2019-04-18
2018 Danuta Kruk, Elzbieta Masiewicz, Evrim Umut, Hermann Scharfetter
1 H relaxation and dynamics of triphenylbismuth in deuterated solvents
published pages: 1-6, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1513175 		Molecular Physics 2019-04-18
2018 Danuta Kruk, Christian Goesweiner, Elzbieta Masiewicz, Evrim Umut, Carina Sampl, Hermann Scharfetter
Model – free approach to quadrupole spin relaxation in solid 209 Bi-aryl compounds
published pages: 23414-23423, ISSN: 1463-9076, DOI: 10.1039/C8CP03848A 		Physical Chemistry Chemical Physics 20/36 2019-04-18
2016 Hermann Scharfetter
An electronically tuned wideband probehead for NQR spectroscopy in the VHF range
published pages: 90-98, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2016.08.008 		Journal of Magnetic Resonance 271 2019-02-20
2016 C. Gösweiner; R. Fischer; M. Schlögl; D. Kruk; A. Petrovic; S. Spirk; H. Scharfetter
Novel smart MRI contrast agents based on nuclear quadrupole cross relaxation – pre-selection of promising compounds
published pages: 247–400, ISSN: 0968-5243, DOI: 10.5281/zenodo.159270 		Magnetic Resonance Materials in Physics, Biology and Medicine ESMRMB Congress, September 2016 2019-02-20
2016 Božič Mojca, Bračič Matej, Doris Tkaučič, Silvo Hribernik, Manja Kurečič, Kargl Rupert, Spirk Stefan, Mohan Tamilselvan, Stana-Kleinschek Karin
NOVEL POLYSACCHARIDE-BASED NANOPARTICLES AND THEIR POTENTIAL APPILCATION IN biomedical IMAGING
published pages: , ISSN: , DOI: 		2019-02-20

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