Opendata, web and dolomites
DermalTherapy
Membrane fusion mediated dermal allergy immunotherapy
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0DermalTherapy project word cloud
Explore the words cloud of the DermalTherapy project. It provides you a very rough idea of what is the project "DermalTherapy" about.
membranes
combining
v1
efficient
protocols
immune
immunological
vaccines
tolerance
form
subcutaneous
unfortunately
grant
monthly
intramuscular
coile
microneedle
idea
starting
allergen
cellular
chronic
membrane
treating
peptide
opposing
vaccinations
coilk
drug
carriers
encapsulated
amphiphiles
mediated
cells
vaccine
patient
platform
immunotherapy
rbet
causing
asthma
pair
solution
induce
allergy
heterodimeric
coil
commercially
administration
stress
lasting
efficacy
direct
shorter
safer
performed
offers
liposomes
shown
coiled
erc
complementary
coils
safety
desired
patients
background
live
extracts
injections
allergies
profile
skin
fusion
dermal
compounds
pain
Project "DermalTherapy" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITEIT LEIDEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 150˙000 € |
| EC max contribution | 150˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2016-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITEIT LEIDEN | NL (LEIDEN) | coordinator | 150˙000.00 |
Map
Project objective
In this project we aim to develop a new delivery platform for allergy vaccines with a high efficacy and a high safety profile combining membrane fusion-mediated delivery and microneedle-based dermal delivery.
Background: Within the ERC Starting Grant “Direct Drug Delivery”, I developed a method for the controlled fusion of liposomes with cells. A set of complementary peptide amphiphiles (coilK and coilE), able to form heterodimeric coiled coils, were shown to induce targeted and efficient fusion between two opposing membranes. More importantly, we have shown that this method of fusion can be applied to liposomes and to live cells. Since liposomes can be used as drug or vaccine carriers, this enables the direct delivery of these compounds into live cells.
The Problem: Allergen-specific immunotherapy for treating allergies such as asthma is currently performed via chronic subcutaneous administration of allergen extracts to patients. Unfortunately, it requires monthly injections for several years to achieve the desired long-lasting immunological tolerance. These vaccinations are typically performed by intramuscular or subcutaneous injections, causing pain and stress. Therefore there is a need for a new and more efficient administration platform to achieve shorter, safer and more patient-friendly protocols.
Our solution: Dermal delivery of vaccines offers a great potential, due to the large number of immune cells present in the skin. In order to increase the efficacy of current allergen-specific immunotherapy, it is our idea to use the membrane fusion heterodimeric coiled coil peptide pair to induce efficient cellular uptake and processing of a commercially used allergen (rBet v1) encapsulated in liposomes in order to increase its efficacy as an allergy vaccine.
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The information about "DERMALTHERAPY" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-09-17 11:53:46) correctly updated