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OPTIMALZ SIGNED

Optical imaging of ocular pathology in Alzheimer’s disease

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 OPTIMALZ project word cloud

Explore the words cloud of the OPTIMALZ project. It provides you a very rough idea of what is the project "OPTIMALZ" about.

mouse    disease    simultaneously    performs    emerge    join    plaques    longitudinally    time    intrinsic    characterization    quantitative    retinal    pathogenesis    pathological    preclinical    beta    ad    ultrasound    detection    unite    alternative    micron    mode    microstructure    units    correlating    light    polarization    3d    brain    powerful    caused    aging    vivo    analogous    populations    parallel    eye    standard    birefringent    particles    pathology    lens    cerebral    retina    diagnosis    provides    attractive    perform    novel    deposited    amyloid    lesions    optical    diagnostic    measured    plaque    ocular    biological    manifestations    flow    blood    coherence    imaged    waves    worldwide    acoustical    longitudinal    tomography    potentially    channels    structural    resolution    pathophysiological    insights    imaging    microvasculature    neuronal    models    contrast    technique    alzheimer    techniques    progression    cell    functional    load    threefold    situ    tissues    additional    window    movement    noninvasive    shed    monitored    oct   

Project "OPTIMALZ" data sheet

The following table provides information about the project.

Coordinator		 MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Austria [AT]
 Project website http://optimalz.eu/
 Total cost 1˙497˙000 €
 EC max contribution 1˙497˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 1˙497˙000.00

Map

 Project objective

Novel diagnostic techniques and disease models have the powerful potential to provide new insights into pathological and pathophysiological processes. Ocular manifestations of Alzheimer’s disease (AD) emerge as novel and attractive alternative to investigate disease progression in parallel to the brain. Using the eye as a window to the brain, we propose to develop multi-functional optical coherence tomography (OCT) as a noninvasive in-vivo technique for preclinical imaging of AD pathology. OCT is analogous to ultrasound B-mode imaging, using light rather than acoustical waves, and performs high-resolution real time 3D imaging of microstructure in biological tissues in situ. Based on the optical polarization properties or movement of particles, functional OCT methods provide additional contrast channels. In the proposed project, we will unite/join standard and functional OCT for imaging ocular and cerebral pathology in AD mouse models with threefold contrast. Structural changes caused by neuronal cell loss in the retina will be assessed longitudinally and with micron-scale resolution. Beta-amyloid plaques are birefringent and are deposited in both brain and retina in AD. We propose to exploit these intrinsic polarization properties for noninvasive detection and longitudinal characterization/assessment of retinal plaque load. Simultaneously, we will assess AD-related changes in retinal microvasculature. Retinal blood flow will be measured in quantitative units and monitored during disease progression. In addition to the retina, we will perform longitudinal imaging of AD-related lesions in the ocular lens with OCT. By correlating ocular AD pathology as imaged with OCT to cerebral lesions, the proposed research provides a new set of in vivo parameters that potentially shed new light on the pathogenesis and impact early diagnosis of AD in aging populations worldwide.

 Publications

year authors and title journal last update
List of publications.
2020 Danielle J. Harper, Marco Augustin, Antonia Lichtenegger, Johanna Gesperger, Tanja Himmel, Martina Muck, Conrad W. Merkle, Pablo Eugui, Stefan Kummer, Adelheid Woehrer, Martin Glösmann, Bernhard Baumann
Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography
published pages: 1, ISSN: 2329-423X, DOI: 10.1117/1.nph.7.1.015006 		Neurophotonics 7/01 2020-04-07
2019 Pablo Eugui, Danielle J. Harper, Antonia Lichtenegger, Marco Augustin, Conrad W. Merkle, Adelheid Woehrer, Christoph K. Hitzenberger, Bernhard Baumann
Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography
published pages: 4040, ISSN: 0146-9592, DOI: 10.1364/ol.44.004040 		Optics Letters 44/16 2020-04-07
2020 Antonia Lichtenegger
Multimodal visible light optical coherence microscopy for ex vivo brain imaging
published pages: , ISSN: , DOI: 		2020-04-07
2019 Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Martina Muck, Pablo Eugui, Danielle J. Harper, Matthias Salas, Marco Augustin, Conrad W. Merkle, Christoph K. Hitzenberger, Georg Widhalm, Adelheid Woehrer, Bernhard Baumann
Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging
published pages: 1, ISSN: 1083-3668, DOI: 10.1117/1.jbo.24.6.066010 		Journal of Biomedical Optics 24/06 2020-04-07
2019 Thomas Roetzer, Konrad Leskovar, Nadine Peter, Julia Furtner, Martina Muck, Marco Augustin, Antonia Lichtenegger, Martha Nowosielski, Johannes A. Hainfellner, Bernhard Baumann, Adelheid Woehrer
Evaluating cellularity and structural connectivity on whole brain slides using a custom-made digital pathology pipeline
published pages: 215-221, ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2018.10.029 		Journal of Neuroscience Methods 311 2020-04-07
2019 Danielle J. Harper, Thomas Konegger, Marco Augustin, Kornelia Schützenberger, Pablo Eugui, Antonia Lichtenegger, Conrad W. Merkle, Christoph K. Hitzenberger, Martin Glösmann, Bernhard Baumann
Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium
published pages: 14, ISSN: 1864-063X, DOI: 10.1002/jbio.201900153 		Journal of Biophotonics 12/12 2020-04-07
2019 Johanna Gesperger, Antonia Lichtenegger, Thomas Roetzer, Marco Augustin, Danielle J. Harper, Pablo Eugui, Conrad W. Merkle, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography
published pages: 2100, ISSN: 2076-3417, DOI: 10.3390/app9102100 		Applied Sciences 9/10 2020-04-07
2020 Danielle J. Harper
Depth-resolved multi-contrast retinal imaging with high axial resolution
published pages: , ISSN: , DOI: 		2020-04-07
2019 Bernhard Baumann, Conrad W. Merkle, Rainer A. Leitgeb, Marco Augustin, Andreas Wartak, Michael Pircher, Christoph K. Hitzenberger
Signal averaging improves signal-to-noise in OCT images: But which approach works best, and when?
published pages: 5755, ISSN: 2156-7085, DOI: 10.1364/boe.10.005755 		Biomedical Optics Express 10/11 2020-04-07
2016 Stanislava Fialová
High resolution polarization sensitive optical coherence tomography for ocular imaging in small animals
published pages: , ISSN: , DOI: 		2020-04-07
2018 Danielle J. Harper, Marco Augustin, Antonia Lichtenegger, Pablo Eugui, Carlos Reyes, Martin Glösmann, Christoph K. Hitzenberger, Bernhard Baumann
White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina
published pages: 2115, ISSN: 2156-7085, DOI: 10.1364/boe.9.002115 		Biomedical Optics Express 9/5 2020-04-07
2017 Antonia Lichtenegger, Danielle J. Harper, Marco Augustin, Pablo Eugui, Martina Muck, Johanna Gesperger, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples
published pages: 4007, ISSN: 2156-7085, DOI: 10.1364/BOE.8.004007 		Biomedical Optics Express 8/9 2020-04-07
2018 Marco Augustin, Danielle J. Harper, Conrad W. Merkle, Christoph K. Hitzenberger, Bernhard Baumann
Segmentation of Retinal Layers in OCT Images of the Mouse Eye Utilizing Polarization Contrast
published pages: 310-318, ISSN: , DOI: 10.1007/978-3-030-00949-6_37 		2020-04-07
2018 Marco Augustin
Multi-Functional Optical Coherence Tomography for Preclinical Retinal Imaging
published pages: , ISSN: , DOI: 		2020-04-07
2016 Marco Augustin, Stanislava Fialová, Tanja Himmel, Martin Glösmann, Theresia Lengheimer, Danielle J. Harper, Roberto Plasenzotti, Michael Pircher, Christoph K. Hitzenberger, Bernhard Baumann
Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model
published pages: 164419, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0164419 		PLOS one 11(10) 2020-04-07
2017 Bernhard Baumann, Adelheid Woehrer, Gerda Ricken, Marco Augustin, Christian Mitter, Michael Pircher, Gabor G. Kovacs, Christoph K. Hitzenberger
Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy
published pages: 43477, ISSN: 2045-2322, DOI: 10.1038/srep43477 		Scientific Reports 7 2020-04-07
2017 Stanislava Fialová, Marco Augustin, Corinna Fischak, Leopold Schmetterer, Stephan Handschuh, Martin Glösmann, Michael Pircher, Christoph K. Hitzenberger, Bernhard Baumann
Posterior rat eye during acute intraocular pressure elevation studied using polarization sensitive optical coherence tomography
published pages: 298-314, ISSN: 2156-7085, DOI: 10.1364/BOE.8.000298 		Biomedical Optics Express 8 2020-04-07
2017 Marco Augustin, Stanislava Fialová, Corinna Fischak, Leopold Schmetterer, Christoph K. Hitzenberger, Bernhard Baumann
Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-09310-1 		Scientific Reports 7/1 2020-04-07
2018 Bernhard Baumann, Marco Augustin, Antonia Lichtenegger, Danielle J. Harper, Martina Muck, Pablo Eugui, Andreas Wartak, Michael Pircher, Christoph K. Hitzenberger
Polarization-sensitive optical coherence tomography imaging of the anterior mouse eye
published pages: 1, ISSN: 1083-3668, DOI: 10.1117/1.JBO.23.8.086005 		Journal of Biomedical Optics 23/08 2020-04-07
2018 Rainer A. Leitgeb, Bernhard Baumann
Multimodal Optical Medical Imaging Concepts Based on Optical Coherence Tomography
published pages: 114, ISSN: 2296-424X, DOI: 10.3389/fphy.2018.00114 		Frontiers in Physics 6 2020-04-07
2018 Antonia Lichtenegger, Martina Muck, Pablo Eugui, Danielle J. Harper, Marco Augustin, Konrad Leskovar, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope
published pages: 1, ISSN: 2329-423X, DOI: 10.1117/1.NPh.5.3.035002 		Neurophotonics 5/03 2020-04-07
2018 Johanna Klughammer, Barbara Kiesel, Thomas Roetzer, Nikolaus Fortelny, Amelie Nemc, Karl-Heinz Nenning, Julia Furtner, Nathan C. Sheffield, Paul Datlinger, Nadine Peter, Martha Nowosielski, Marco Augustin, Mario Mischkulnig, Thomas Ströbel, Donat Alpar, Bekir Ergüner, Martin Senekowitsch, Patrizia Moser, Christian F. Freyschlag, Johannes Kerschbaumer, Claudius Thomé, Astrid E. Grams, Günther Stockhammer, Melitta Kitzwoegerer, Stefan Oberndorfer, Franz Marhold, Serge Weis, Johannes Trenkler, Johanna Buchroithner, Josef Pichler, Johannes Haybaeck, Stefanie Krassnig, Kariem Mahdy Ali, Gord von Campe, Franz Payer, Camillo Sherif, Julius Preiser, Thomas Hauser, Peter A. Winkler, Waltraud Kleindienst, Franz Würtz, Tanisa Brandner-Kokalj, Martin Stultschnig, Stefan Schweiger, Karin Dieckmann, Matthias Preusser, Georg Langs, Bernhard Baumann, Engelbert Knosp, Georg Widhalm, Christine Marosi, Johannes A. Hainfellner, Adelheid Woehrer, Christoph Bock
The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
published pages: 1611-1624, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0156-x 		Nature Medicine 24/10 2020-04-07
2018 Pablo Eugui, Antonia Lichtenegger, Marco Augustin, Danielle J. Harper, Martina Muck, Thomas Roetzer, Andreas Wartak, Thomas Konegger, Georg Widhalm, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Beyond backscattering: optical neuroimaging by BRAD
published pages: 2476, ISSN: 2156-7085, DOI: 10.1364/BOE.9.002476 		Biomedical Optics Express 9/6 2020-04-07

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