Explore the words cloud of the ZF-MEL-CHEMBIO project. It provides you a very rough idea of what is the project "ZF-MEL-CHEMBIO" about.
The following table provides information about the project.
Coordinator |
THE UNIVERSITY OF EDINBURGH
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Total cost | 1˙865˙345 € |
EC max contribution | 1˙865˙345 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-CoG |
Funding Scheme | ERC-COG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-09-01 to 2021-08-31 |
Take a look of project's partnership.
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1 | THE UNIVERSITY OF EDINBURGH | UK (EDINBURGH) | coordinator | 1˙865˙345.00 |
Melanoma (cancer of the melanocyte) kills over 20,000 Europeans each year and incidence continues to rise rapidly. BRAF(V600E) inhibitors have led to clinically significant improvements in outcomes for melanoma patients, yet many patients with metastatic melanoma rapidly succumb to the disease due to eventual chemoresistance, or insensitivity to the drug. Thus, it is critical to identify new therapies that can act alone, or be combined with available treatments for enhanced efficacy and/or to overcome drug resistance.
An important and new therapeutic concept for melanoma is to target the melanocyte lineage. Recent evidence reveals that a melanocyte lineage specific programme maintains melanoma survival, and we have engineered the first animal model in zebrafish to demonstrate that targeting the master melanocyte lineage transcription factor MITF leads to rapid melanoma regression. Thus, understanding and targeting the melanocyte lineage is directly relevant to melanoma, and reveals therapeutically targetable processes.
Our vision is to use live-imaging of the melanocyte lineage as the basis for phenotypic chemical screens in zebrafish to find drugs/leads and identify targetable processes that might elucidate pathways for cancer therapy. Screening for targets of the melanocyte lineage is highly relevant to melanoma because melanocytes are the melanoma cell of origin, and genes that specify the melanocyte stem cells and the lineage during embryogenesis are the same genes that play fundamental roles in cancer. We will use innovative chemical-biology to capture and validate targets in vivo, and perform chemo-preventative and -therapeutic trials in zebrafish melanoma models using known and novel drug-delivery methods.
Ultimately, we aim to translate our most promising drug/leads and targets into the mammalian system, to establish the basis for patent applications and clinical trials.
year | authors and title | journal | last update |
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2019 |
Jana Travnickova, Sonia Wojciechowska, Ava Khamseh, Philippe Gautier, Daniel V. Brown, Thomas Lefevre, Alessandro Brombin, Ailith Ewing, Amy Capper, Michaela Spitzer, Ramile Dilshat, Colin A. Semple, Marie E. Mathers, James A. Lister, EirÃkur Steingrimsson, Thierry Voet, Chris P. Ponting, E. Elizabeth Patton Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease published pages: 5769-5784, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-19-0037 |
Cancer Research 79/22 | 2020-03-31 |
2019 |
E. Elizabeth Patton, David M. Tobin Spotlight on zebrafish: the next wave of translational research published pages: dmm039370, ISSN: 1754-8403, DOI: 10.1242/dmm.039370 |
Disease Models & Mechanisms 12/3 | 2020-03-31 |
2018 |
Zhiqiang Zeng, Juan Lopez-Baez, Laura Lleras-Forero, Hannah Brunsdon, Cameron Wyatt, Witold Rybski, Nicholas Hastie, Stefan Schulte-Merker, E Patton Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3100 |
BIO-PROTOCOL 8/23 | 2020-03-31 |
2018 |
Kao Chin Ngeow, Hans J. Friedrichsen, Linxin Li, Zhiqiang Zeng, Sarah Andrews, Laurent Volpon, Hannah Brunsdon, Georgina Berridge, Sarah Picaud, Roman Fischer, Richard Lisle, Stefan Knapp, Panagis Filippakopoulos, Helen Knowles, EirÃkur SteingrÃmsson, Katherine L. B. Borden, E. Elizabeth Patton, Colin R. Goding BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export published pages: E8668-E8677, ISSN: 0027-8424, DOI: 10.1073/pnas.1810498115 |
Proceedings of the National Academy of Sciences 115/37 | 2020-03-31 |
2018 |
Thomas L. Bray, Mark Salji, Alessandro Brombin, Ana M. Pérez-López, Belén Rubio-Ruiz, Laura C. A. Galbraith, E. Elizabeth Patton, Hing Y. Leung, Asier Unciti-Broceta Bright insights into palladium-triggered local chemotherapy published pages: 7354-7361, ISSN: 2041-6520, DOI: 10.1039/c8sc02291g |
Chemical Science 9/37 | 2020-03-31 |
2019 |
Karen Camargo-Sosa, Sarah Colanesi, Jeanette Müller, Stefan Schulte-Merker, Derek Stemple, E. Elizabeth Patton, Robert N. Kelsh Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish published pages: e1007941, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007941 |
PLOS Genetics 15/2 | 2020-03-31 |
2019 |
Ashani T. Weeraratna, E. Elizabeth Patton Supporting women in science at PCMR published pages: 484-485, ISSN: 1755-1471, DOI: 10.1111/pcmr.12798 |
Pigment Cell & Melanoma Research 32/4 | 2020-03-31 |
2018 |
Hannah Brunsdon, E Elizabeth Patton Fishing for ancestry published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.39524 |
eLife 7 | 2020-03-31 |
2016 |
N. P. Macdonald, F. Zhu, C. J. Hall, J. Reboud, P. S. Crosier, E. E. Patton, D. Wlodkowic, J. M. Cooper Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays published pages: 291-297, ISSN: 1473-0197, DOI: 10.1039/C5LC01374G |
Lab Chip 16/2 | 2020-01-24 |
2017 |
Ian J. Jackson, E. Elizabeth Patton Cell signalling: Red alert about lipid\'s role in skin cancer published pages: 337-339, ISSN: 0028-0836, DOI: 10.1038/nature23550 |
Nature 549/7672 | 2020-01-24 |
2015 |
Lidia Kos, E. Elizabeth Patton, Maria S. Soengas Let\'s make it happen: for gender equality in science! published pages: 641-642, ISSN: 1755-1471, DOI: 10.1111/pcmr.12421 |
Pigment Cell & Melanoma Research 28/6 | 2020-01-24 |
2017 |
Maria S. Soengas, E. Elizabeth Patton Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma published pages: 559-561, ISSN: 1934-5909, DOI: 10.1016/j.stem.2017.10.009 |
Cell Stem Cell 21/5 | 2020-01-24 |
2016 |
S. Wojciechowska, E. van Rooijen, C. Ceol, E.E. Patton, R.M. White Generation and analysis of zebrafish melanoma models published pages: 531-549, ISSN: 0091-679X, DOI: 10.1016/bs.mcb.2016.03.008 |
Methods Cell Biol. | 2020-01-24 |
2018 |
Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas S. Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim M. Keppler-Noreuil, Amjad Khan, Marjorie J. Lindhurst, Mark Lipson, Sahar Mansour, Justine O’Hara, Caroline Mahon, Anda Mosica, Celia Moss, Aditi Murthy, Juling Ong, Victoria E. Parker, Jean-Baptiste Rivière, Julie C. Sapp, Neil J. Sebire, Rahul Shah, Branavan Sivakumar, Anna Thomas, Alex Virasami, Regula Waelchli, Zhiqiang Zeng, Leslie G. Biesecker, Alex Barnacle, Maya Topf, Robert K. Semple, E. Elizabeth Patton, Veronica A. Kinsler Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy published pages: 1496-1508, ISSN: 0021-9738, DOI: 10.1172/JCI98589 |
Journal of Clinical Investigation 128/4 | 2020-01-24 |
2016 |
Sonia Wojciechowska, Zhiqiang Zeng, James A. Lister, Craig J. Ceol, E. Elizabeth Patton Melanoma Regression and Recurrence in Zebrafish published pages: 143-153, ISSN: 1940-6029, DOI: 10.1007/978-1-4939-3771-4_10 |
Methods Mol Biol. | 2020-01-24 |
2016 |
Louise van der Weyden, E Elizabeth Patton, Geoffrey A Wood, Alastair K Foote, Thomas Brenn, Mark J Arends, David J Adams Cross-species models of human melanoma published pages: 152-165, ISSN: 0022-3417, DOI: 10.1002/path.4632 |
The Journal of Pathology 238/2 | 2020-01-24 |
2016 |
Craig Fraser, John C. Dawson, Reece Dowling, Douglas R. Houston, Jason T. Weiss, Alison F. Munro, Morwenna Muir, Lea Harrington, Scott P. Webster, Margaret C. Frame, Valerie G. Brunton, E. Elizabeth Patton, Neil O. Carragher, Asier Unciti-Broceta Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase published pages: 4697-4710, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00065 |
Journal of Medicinal Chemistry 59/10 | 2020-01-24 |
2016 |
Gareth Griffiths, Ferenc Müller, Johan Ledin, E. Elizabeth Patton, Tor Gjøen, Viola Hélène Lobert, Hanne Cecilie Winther-Larsen, Mary Mullins, Jean-Stephane Joly, Finn-Arne Weltzien, Charles McLean Press, Peter Aleström Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo published pages: 132-137, ISSN: 1545-8547, DOI: 10.1089/zeb.2015.1212 |
Zebrafish 13/2 | 2020-01-24 |
2017 |
Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Sonia Wojciechowska, Richard J. White, John E. Collins, Derek L. Stemple, Till Bartke, Marie E. Mathers, E. Elizabeth Patton, Elisabeth M. Busch-Nentwich Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish published pages: e1006959, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006959 |
PLOS Genetics 13/8 | 2020-01-24 |
2018 |
Juan Carlos Lopez-Baez, Daniel J Simpson, Laura LLeras Forero, Zhiqiang Zeng, Hannah Brunsdon, Angela Salzano, Alessandro Brombin, Cameron Wyatt, Witold Rybski, Leonie F A Huitema, Rodney M Dale, Koichi Kawakami, Christoph Englert, Tamir Chandra, Stefan Schulte-Merker, Nicholas D Hastie, E Elizabeth Patton Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.30657 |
eLife 7 | 2020-01-24 |
2018 |
Sana Sarvi, Richard Crispin, Yuting Lu, Lifan Zeng, Thomas D. Hurley, Douglas R. Houston, Alex von Kriegsheim, Che-Hong Chen, Daria Mochly-Rosen, Marco Ranzani, Marie E. Mathers, Xiaowei Xu, Wei Xu, David J. Adams, Neil O. Carragher, Mayumi Fujita, Lynn Schuchter, Asier Unciti-Broceta, Valerie G. Brunton, E. Elizabeth Patton ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells published pages: , ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.09.005 |
Cell Chemical Biology | 2020-01-24 |
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