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Troy Stem Cells SIGNED

Troy+ stomach stem cells in homeostasis, repair and pathogenesis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Troy Stem Cells project word cloud

Explore the words cloud of the Troy Stem Cells project. It provides you a very rough idea of what is the project "Troy Stem Cells" about.

quiescent vitro adult expression potentially nature pursue fate dynamics pathological switch normal hostile genetics intestinal proximal reproduced gastro mechanism repair homeostasis suggesting proliferative subsequently divided proliferation stomach genes chief underlying specialized exposure tract fore stress analysing injury actively exhibit stem damage contents vivo model pylorus constant generate interesting unmasking constantly propagation population indicating characterising characterise rate interconvertible list molecular regeneration mrna functional epigenetic human lastly tissue mammalian cells types cell distal troy statuses parts profiles interestingly decisions function divide lumen gastrointestinal displayed corpus epithelium functions distinctive mechanical

Project "Troy Stem Cells" data sheet

The following table provides information about the project.

Coordinator	INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH Organization address address: DR BOHRGASSE 3 city: WIEN postcode: 1030 website: www.imba.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Project website	http://www.stemcells.cam.ac.uk/research/pis/koo
Total cost	1˙570˙398 €
EC max contribution	1˙570˙398 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-08-01 to 2020-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH Organization address address: DR BOHRGASSE 3 city: WIEN postcode: 1030 website: www.imba.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	570˙478.00
2	THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	715˙398.00
3	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	284˙522.00

Map

Project objective

The adult mammalian stomach can be divided into three distinct parts: From the proximal fore-stomach over the corpus to the distal pylorus. Due to constant exposure to mechanical stress and to hostile contents of the lumen, highly specialized cell types have to be constantly reproduced in order to maintain the function of the gastrointestinal tract. Recently, the applicant identified Troy chief cells as a novel stem cell population in the corpus epithelium. Troy chief cells displayed a very low proliferation rate indicating their quiescent nature compared to other known gastro-intestinal tract stem cells. Interestingly, these stem cells can actively divide upon tissue damage, suggesting distinctive statuses under conditions of homeostasis and injury.

As Troy stomach stem cells exhibit interconvertible characteristics i.e. quiescent and proliferative, they represent a unique model of adult stem cells with which we can study 1) the dynamics of stem cell propagation in homeostasis and regeneration and the underlying mechanism of this switch by analysing molecular and epigenetic profiles. Subsequently, by analysing mRNA expression profiles and epigenetic changes in Troy stem cells between homeostasis and injury repair, we will generate a list of genes with potentially interesting functions in cell fate decisions. We will therefore investigate 2) the stomach stem cell programme in homeostasis and regeneration using in vitro and in vivo functional genetics. Lastly, we will characterise 3) human stomach stem cells in normal and pathological conditions.

Here we pursue three main aims: - Investigating Troy stem cell dynamics during homeostasis and injury repair - Unmasking the stomach stem cell programme using in vitro and in vivo functional genetics - Characterising human stomach stem cells

Publications

List of publications.
year	authors and title	journal	last update
2018	Maureen Spit, Bon-Kyoung Koo, Madelon M. Maurice Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer published pages: 180120, ISSN: 2046-2441, DOI: 10.1098/rsob.180120	Open Biology 8/9	2019-06-06
2019	Szu-Hsien (Sam) Wu, Ji-Hyun Lee, and Bon-Kyoung Koo Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging published pages: , ISSN: 0219-1032, DOI: 10.14348/molcells.2019.0006	Molecules and Cells	2019-06-06
2017	Amanda Andersson-Rolf, Matthias Zilbauer, Bon-Kyoung Koo, Hans Clevers Stem Cells in Repair of Gastrointestinal Epithelia published pages: 278-289, ISSN: 1548-9213, DOI: 10.1152/physiol.00005.2017	Physiology 32/4	2019-06-06
2019	Therese Seidlitz, Sebastian R Merker, Alexander Rothe, Falk Zakrzewski, ClÃ¤re von Neubeck, Konrad GrÃ¼tzmann, Ulrich Sommer, Christine Schweitzer, Sebastian SchÃ¶lch, Heike Uhlemann, Anne-Marlene Gaebler, Kristin Werner, Mechthild Krause, Gustavo B Baretton, Thilo Welsch, Bon-Kyoung Koo, Daniela E Aust, Barbara Klink, JÃ¼rgen Weitz, Daniel E Stange Human gastric cancer modelling using organoids published pages: 207-217, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2017-314549	Gut 68/2	2019-06-06
2018	Juergen Fink, Seungmin Han, David J. JÃ¶rg, Sebastian R. Merker, Eunmin Lee, Min Kyu Yum, Ji-Hyun Lee, Manon Josserand, Teodora Trendafilova, Amanda Andersson-Rolf, Catherine Dabrowska, Hyunki Kim, Nobuo Sasaki, Richard Lester Mort, Onur Basak, Hans Clevers, Daniel E. Stange, Jong-Kyoung Kim, Benjamin D. Simons, Bonkyoung Koo Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells published pages: , ISSN: 1556-5068, DOI: 10.2139/ssrn.3213913	SSRN Electronic Journal	2019-06-06
2019	Jihoon Kim, Bon-Kyoung Koo, Ki-Jun Yoon Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology published pages: 124, ISSN: 1999-4915, DOI: 10.3390/v11020124	Viruses 11/2	2019-06-06

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The information about "TROY STEM CELLS" are provided by the European Opendata Portal: CORDIS opendata.