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ProteinConjugates SIGNED

A training network for the chemical site-selective modification of proteins: Preparation of the next-generation of therapeutic chemically-defined protein conjugates

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ProteinConjugates project word cloud

Explore the words cloud of the ProteinConjugates project. It provides you a very rough idea of what is the project "ProteinConjugates" about.

create training multidisciplinary host inter modification groups beneficiaries self pis synthesis combined young area construct postdocs dynamic site industrial sme cancer protein chemically conjugates treatment selective interaction engineering exposure arthritis phds antibody academic biotherapeutics leaders supramolecular molecules skills education industry proteinconjugates academy innovative disciplinary generation scientists serious centre competitiveness ideas chemical rheumatoid pharmaceutical expertise environment complementary talented rationally dynamics molecular network assembly secondments therapeutics drug

Project "ProteinConjugates" data sheet

The following table provides information about the project.

Coordinator	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	http://www.ff.ul.pt/proteinconjugatesitn/
Total cost	2˙542˙771 €
EC max contribution	2˙542˙770 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-11-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	741˙939.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	273˙287.00
3	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	273˙287.00
4	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
5	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	255˙934.00
6	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	249˙216.00
7	UNIVERSIDAD DE LA RIOJA UNIVERSIDAD DE LA RIOJA Organization address address: AVENIDA DE LA PAZ 93 city: LA RIOJA postcode: 26006 website: www.unirioja.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LA RIOJA)	participant	247˙872.00
8	Faculdade de Farmácia da Universidade de Lisboa Faculdade de Farmácia da Universidade de Lisboa Organization address address: Av. Prof. Gama Pinto city: Lisboa postcode: 1649-003 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (Lisboa)	participant	238˙356.00
9	UNIVERSITAET ULM UNIVERSITAET ULM Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 website: www.uni-ulm.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ULM)	participant	0.00
10	HOVIONE FARMACIENCIA SA HOVIONE FARMACIENCIA SA Organization address address: SETE CASAS city: LOURES postcode: 2674 506 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LOURES)	partner	0.00
11	PHARMAMAR, S.A. PHARMAMAR, S.A. Organization address address: Avda. de los Reyes , Poligono Industrial La Mina 1 city: COLMENAR VIEJO (MADRID) postcode: 28770 website: www.pharmamar.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (COLMENAR VIEJO (MADRID))	partner	0.00

Map

Project objective

ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer or rheumatoid arthritis. A complementary interaction between academy and pharmaceutical industry is at the centre of such a network, which involves 8 academic groups and 1 SME partner as beneficiaries, and 2 leading European industrial partner organizations that will host secondments while providing training. The combined expertise of the beneficiaries and industrial partners in synthesis of complex molecules, molecular dynamics, supramolecular self-assembly, site-selective chemical protein modification, protein/antibody engineering, cancer therapeutics and drug development together with the experience in project management and training of PhDs and Postdocs of the PIs, will create a multidisciplinary environment where 10 young researchers can foster their knowledge and skills while developing the most innovative ideas in the emerging fields of chemical site-selective protein modification and protein biotherapeutics. Exposure to the highly dynamic and multidisciplinary ProteinConjugates environment will contribute to the education of the next generation of leaders in the emerging field of protein biotherapeutics, a key area of research and drug development for Europe's competitiveness.

Deliverables

List of deliverables.
Project Finish	Other	2020-04-24 23:09:55
A new GMP manufacturing platform	Other	2020-04-24 23:12:35
Construction of sillafin based drug delivery systems	Other	2020-04-24 23:11:55
Summer School	Other	2020-04-24 23:09:43
Construction of protein-based nanostructures modified with CAIX ligands	Other	2020-04-24 23:11:40
Evaluation of a new vascular targeting ADC	Other	2020-04-24 23:12:08
Winter School	Other	2020-04-24 23:08:43
Construction of a new Transtuzumab-marine drug ADC	Other	2020-04-24 23:10:46
Construction of a new Transtuzumab-SN38 ADC	Other	2020-04-24 23:10:32
Construction of anti-MUC1-fluorofore conjugate	Other	2020-04-24 23:11:27
Construction of a new CXCR4-bortezomib ADC	Other	2020-04-24 23:11:14
Construction of a new Fab (trastuzumab)-doxoribicin ADC	Other	2020-04-24 23:11:03
New modified silaffins for drug-delivery based on silica nanoparticles	Other	2020-04-24 23:10:07
Construction of a new DM1-antibody L19 ADC vascular targeting ADC	Other	2020-04-24 23:10:20
Evaluation of a new CXR4-bortezobib ADC	Other	2020-04-24 23:12:50
Evaluation of a new homogeneous ADC against HER2	Other	2020-04-24 23:12:21
New method for the site-selective cysteine modification	Other	2020-01-15 14:12:52
Website completion	Websites, patent fillings, videos etc.	2020-01-15 14:12:52
New protein based nanoparticles	Other	2020-01-15 14:12:52
A new method for disulfide bridging with boronic acid coordinating handles	Other	2020-01-15 14:12:52
A new anti-MUC1-antibody 4 UR PDE PU 20 The method involves the design of a new anti-MUC1-antibody with high affinity and selectivity for modified MUC1 glycopeptides	Other	2020-01-15 14:12:52
Project Kick-off	Other	2020-01-15 14:12:52
New method for site-selective tryptophan modification	Other	2020-01-15 14:12:52
A new method for the disulphide bridging	Other	2020-01-15 14:12:52
New modified synthetic lectins	Other	2020-01-15 14:12:52
New method for the site-selective lysine modification	Other	2020-01-15 14:12:52
Construction of lectin based drug delivery systems	Other	2020-01-15 14:12:52
Vacancies advertisement	Other	2020-01-15 14:12:52

Take a look to the deliverables list in detail: detailed list of ProteinConjugates deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, TÃ¢nia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, GonÃ§alo J. L. Bernardes, JoÃ£o T. Barata A fully human anti-IL-7RÎ± antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia published pages: 2155-2168, ISSN: 0887-6924, DOI: 10.1038/s41375-019-0434-8	Leukemia 33/9	2020-03-06
2019	Maria J. Matos, Claudio D. Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L. Saar, Ismael CompaÃ±Ã³n, Francisco Corzana, Tuomas P. J. Knowles, Gonzalo JimÃ©nez-OsÃ©s, GonÃ§alo J. L. Bernardes Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation published pages: 6640-6644, ISSN: 1433-7851, DOI: 10.1002/anie.201901405	Angewandte Chemie International Edition 58/20	2020-03-06
2019	Maria J. Matos, Claudio D. Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L. Saar, Ismael CompaÃ±Ã³n, Francisco Corzana, Tuomas P. J. Knowles, Gonzalo JimÃ©nezâ€OsÃ©s, GonÃ§alo J. L. Bernardes Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteineâ€Selective Protein Modification and Charge Modulation published pages: 6712-6716, ISSN: 0044-8249, DOI: 10.1002/ange.201901405	Angewandte Chemie 131/20	2020-03-06
2019	Barbara Bernardim, Maria J. Matos, Xhenti Ferhati, Ismael CompaÃ±Ã³n, Ana Guerreiro, Padma Akkapeddi, Antonio C. B. Burtoloso, Gonzalo JimÃ©nez-OsÃ©s, Francisco Corzana, GonÃ§alo J. L. Bernardes Efficient and irreversible antibodyâ€“cysteine bioconjugation using carbonylacrylic reagents published pages: 86-99, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0083-9	Nature Protocols 14/1	2020-03-06
2019	Charlotte Baker, Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, GonÃ§alo J.L. Bernardes Natural productâ€“drug conjugates for modulation of TRPV1-expressing tumors published pages: 2531-2536, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.03.025â€‹	Bioorganic & Medicinal Chemistry 27/12	2020-03-06
2019	Marco Hebel, Andreas Riegger, Maksymilian M. Zegota, GÃ¶nÃ¼l Kizilsavas, Jasmina GaÄanin, Michaela Pieszka, Thorsten LÃ¼ckerath, Jaime A. S. Coelho, Manfred Wagner, Pedro M. P. Gois, David Y. W. Ng, Tanja Weil Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes published pages: 14026-14031, ISSN: 0002-7863, DOI: 10.1021/jacs.9b03107	Journal of the American Chemical Society 141/36	2020-03-06
2018	Ludger Johannes, Marco Lucchino Current Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAs published pages: 178-193, ISSN: 2159-3337, DOI: 10.1089/nat.2017.0716	Nucleic Acid Therapeutics 28/3	2020-03-06
2019	Giorgia Del Favero, Friedrich Bialas, Stephanie Grabher, Anja Wittig, Birgit BrÃ¤uer, Dagmar Gerthsen, CÃ©cile Echalier, Meder Kamalov, Doris Marko, Christian F. W. Becker Silica particles with a quercetinâ€“R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus published pages: 9649-9652, ISSN: 1359-7345, DOI: 10.1039/c9cc02215e	Chemical Communications 55/65	2020-03-06
2018	Seah Ling Kuan, Stephan Fischer, Susanne Hafner, Tao Wang, Tatiana Syrovets, Weina Liu, Yu Tokura, David Yuen Wah Ng, Andreas Riegger, Christina FÃ¶rtsch, Daniela JÃ¤ger, Thomas F. E. Barth, Thomas Simmet, Holger Barth, Tanja Weil Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins published pages: 1701036, ISSN: 2198-3844, DOI: 10.1002/advs.201701036	Advanced Science 5/8	2020-03-06
2017	Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, JoÃ£o T. Barata From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia published pages: 10-25, ISSN: 0898-6568, DOI: 10.1016/j.cellsig.2017.06.011	Cellular Signalling 38	2020-03-06
2019	Shuang Sun, Padma Akkapeddi, Marta C. Marques, Nuria MartÃnez-SÃ¡ez, Vukosava M. Torres, Carlos Cordeiro, Omar Boutureira, GonÃ§alo J. L. Bernardes One-pot stapling of interchain disulfides of antibodies using an isobutylene motif published pages: 2005-2012, ISSN: 1477-0520, DOI: 10.1039/c8ob02877j	Organic & Biomolecular Chemistry 17/7	2020-03-06
2018	Stefanie Sieste, Thomas Mack, Christopher V. Synatschke, Corinna Schilling, Christopher Meyer zu Reckendorf, Laura Pendi, Sean Harvey, Francesco S. Ruggeri, Tuomas P. J. Knowles, Christoph Meier, David Y. W. Ng, Tanja Weil, Bernd KnÃ¶ll Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion published pages: 1701485, ISSN: 2192-2640, DOI: 10.1002/adhm.201701485	Advanced Healthcare Materials 7/11	2020-03-06
2017	Allyson M. Freedy, Maria J. Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, VÃctor J. Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo JimÃ©nez-OsÃ©s, Kevin M. Brindle, AndrÃ© A. Neves, GonÃ§alo J. L. Bernardes Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation published pages: 18365-18375, ISSN: 0002-7863, DOI: 10.1021/jacs.7b10702	Journal of the American Chemical Society 139/50	2020-03-06
2018	Tiago Rodrigues, Markus Werner, Jakob Roth, Eduardo H. G. da Cruz, Marta C. Marques, Padma Akkapeddi, Susana A. Lobo, Andreas Koeberle, Francisco Corzana, EufrÃ¢nio N. da Silva JÃºnior, Oliver Werz, GonÃ§alo J. L. Bernardes Machine intelligence decrypts Î²-lapachone as an allosteric 5-lipoxygenase inhibitor published pages: 6899-6903, ISSN: 2041-6520, DOI: 10.1039/c8sc02634c	Chemical Science 9/34	2020-03-06
2018	Christiane Seidler, Maksymilian Marek Zegota, Marco Raabe, Seah Ling Kuan, David Y. W. Ng, Tanja Weil Dynamic Core-Shell Bioconjugates for Targeted Protein Delivery and Release published pages: 3474-3479, ISSN: 1861-4728, DOI: 10.1002/asia.201800843	Chemistry - An Asian Journal 13/22	2020-03-06
2019	JoÃ£o P. M. AntÃ³nio, Roberto Russo, CÃ¡tia Parente Carvalho, Pedro M. S. D. Cal, Pedro M. P. Gois Boronic acids as building blocks for the construction of therapeutically useful bioconjugates published pages: 3513-3536, ISSN: 0306-0012, DOI: 10.1039/c9cs00184k	Chemical Society Reviews 48/13	2020-03-06
2019	Mariana L. Oliveira, Padma Akkapeddi, Daniel Ribeiro, Alice MelÃ£o, JoÃ£o T. Barata IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update published pages: 88-96, ISSN: 2212-4926, DOI: 10.1016/j.jbior.2018.09.012	Advances in Biological Regulation 71	2020-03-06
2019	JoÃ£o C. F. Nogueira, Michelle K. Greene, Daniel A. Richards, Alexander O. Furby, John Steven, Andrew Porter, Caroline Barelle, Christopher J. Scott, Vijay Chudasama Oriented attachment of V NAR proteins, via site-selective modification, on PLGAâ€“PEG nanoparticles enhances nanoconjugate performance published pages: 7671-7674, ISSN: 1359-7345, DOI: 10.1039/c9cc02655j	Chemical Communications 55/53	2020-03-06
2018	Jean-Marie Carpier, Andres E. Zucchetti, Laurence Bataille, StÃ©phanie Dogniaux, Massiullah Shafaq-Zadah, Sabine Bardin, Marco Lucchino, Mathieu Maurin, Leonel D. Joannas, Joao Gamelas Magalhaes, Ludger Johannes, Thierry Galli, Bruno Goud, Claire Hivroz Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation published pages: 1245-1265, ISSN: 0022-1007, DOI: 10.1084/jem.20162042	The Journal of Experimental Medicine 215/4	2020-03-06
2018	Maksymilian Marek Zegota, Tao Wang, Christiane Seidler, David Yuen Wah Ng, Seah Ling Kuan, Tanja Weil â€œTag and Modifyâ€ Protein Conjugation with Dynamic Covalent Chemistry published pages: 2665-2670, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00358	Bioconjugate Chemistry 29/8	2020-01-28

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