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ENLIGHT-TEN SIGNED

European Network linking informatics and genomics of helper T cells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ENLIGHT-TEN project word cloud

Explore the words cloud of the ENLIGHT-TEN project. It provides you a very rough idea of what is the project "ENLIGHT-TEN" about.

technological diverse sequencing technologies strengths disciplines platforms roles 13 diseases complementary cross training big integrate demand generate preclinical pharmaceutical cells strengthen critical disciplinary stone therapeutic plasticity perform extrinsic enlight capacity genome academic genomics intrinsic informatics ngs impacts academia linking models esrs autoimmune power stage lies ideal immunology combines stepping enterprises mission differentiation forefront bioinformatics steadily edge creative helper biomarkers emphasis beneficiaries human interrogate data innovative play companies expertise flow cutting identification empowered cell cellular laboratories train editing network combine interdisciplinary generation ten placing enter individual acquire source trainees colour cytometry

Project "ENLIGHT-TEN" data sheet

The following table provides information about the project.

Coordinator	HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.helmholtz-hzi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.enlight-ten.eu
Total cost	3˙354˙685 €
EC max contribution	3˙354˙685 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.helmholtz-hzi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	coordinator	498˙432.00
2	THE BABRAHAM INSTITUTE THE BABRAHAM INSTITUTE Organization address address: Babraham Hall city: CAMBRIDGE postcode: CB22 3AT website: www.babraham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	546˙575.00
3	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	476˙712.00
4	GENOME RESEARCH LIMITED GENOME RESEARCH LIMITED Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE website: http://www.sanger.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	273˙287.00
5	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	273˙287.00
6	TURUN YLIOPISTO TURUN YLIOPISTO Organization address address: YLIOPISTONMAKI city: Turku postcode: 20014 website: www.utu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Turku)	participant	269˙145.00
7	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
8	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	255˙934.00
9	Bayer Pharma AG Bayer Pharma AG Organization address address: Muellerstrasse 178 city: Berlin postcode: 13353 website: www.bayerpharma.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Berlin)	participant	249˙216.00
10	QIAGEN AARHUS AS QIAGEN AARHUS AS Organization address address: SILKEBORGVEJ 2 city: AARHUS postcode: 8000 website: www.clcbio.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS)	participant	249˙216.00
11	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	0.00
12	Abcam plc Abcam plc Organization address address: 330 CAMBRIDGE SCIENCE PARK city: Cambridge postcode: CB4 0FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cambridge)	partner	0.00
13	AFFIRIS AG AFFIRIS AG Organization address address: KARL FARKAS GASSE 22 city: WIEN postcode: 1030 website: www.affiris.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	partner	0.00
14	CRISPR Therapeutics Limited CRISPR Therapeutics Limited Organization address address: Stevenage Bioscience Catalyst, Gunnels Wood Road city: Stevenage postcode: SG1 2FX website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Stevenage)	partner	0.00
15	EAGLE GENOMICS LIMITED EAGLE GENOMICS LIMITED Organization address address: BIODATA INNOVATION CENTRE, WELLCOME GENOME CAMPUS, city: CAMBRIDGE postcode: CB10 1DR website: www.eaglegenomics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	partner	0.00
16	Genomatix Software GmbH Genomatix Software GmbH Organization address address: Bayerstrasse 85a city: Muenchen postcode: 80335 website: www.genomatix.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Muenchen)	partner	0.00
17	NOVIMMUNE SA NOVIMMUNE SA Organization address address: CHEMIN DES AULX 14 city: PLAN LES OUATES GENEVE postcode: 1228 website: www.novimmune.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (PLAN LES OUATES GENEVE)	partner	0.00

Map

Project objective

ENLIGHT-TEN is a European Network Linking Informatics and Genomics of Helper T cells: our mission is to provide cross-disciplinary training in cellular immunology and big data analysis such that we train a new generation of researchers to fully exploit the power of emerging technological platforms. Our network of TEN beneficiaries combines T cell expertise with state-of-the-art technologies such as next generation sequencing (NGS), bioinformatics, multi-colour flow cytometry, preclinical models and tailored genome editing. Trainees will acquire a comprehensive knowledge in T cell immunology and the capacity to generate and interrogate big data sets as well as expertise in identifying novel biomarkers and developing therapeutic concepts. As such the training programme will provide an ideal stepping-stone for creative and innovative early stage researchers (ESRs) to enter and strengthen Europe’s academia as well as pharmaceutical and bioinformatics companies. The research focus of the network lies in the identification of extrinsic and intrinsic factors that control development, differentiation and plasticity of helper T cell subsets with particular emphasis on how T cell differentiation impacts on human diseases. The generation of large data sets is an emerging and challenging field, and there is high demand in both the academic sector as well as pharmaceutical companies for researchers to be able to analyse, integrate and exploit this rich source of information. ENLIGHT-TEN will combine the individual strengths of innovative laboratories and enterprises from complementary disciplines to provide unique interdisciplinary training for 13 ESRs, placing them at the forefront of this emerging field. Trainees will be empowered to perform cutting-edge analysis of the steadily increasing number of different T cell subsets, which play highly diverse and critical roles in the development of autoimmune diseases, making them a key target for pharmaceutical companies.

Deliverables

List of deliverables.
Midterm review meeting	Other	2020-04-07 20:07:59

Take a look to the deliverables list in detail: detailed list of ENLIGHT-TEN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Yi-Ling Chen, Tomas Gomes, Clare S. Hardman, Felipe A. Vieira Braga, Danuta Gutowska-Owsiak, Maryam Salimi, Nicki Gray, David A. Duncan, Gary Reynolds, David Johnson, Mariolina Salio, Vincenzo Cerundolo, Jillian L. Barlow, Andrew N.J. McKenzie, Sarah A. Teichmann, Muzlifah Haniffa, Graham Ogg Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation published pages: , ISSN: 0022-1007, DOI: 10.1084/jem.20190811	The Journal of Experimental Medicine 217/3	2020-04-07
2019	TomÃ¡s Gomes, Sarah A. Teichmann, Carlos Talavera-LÃ³pez Immunology Driven by Large-Scale Single-Cell Sequencing published pages: 1011-1021, ISSN: 1471-4906, DOI: 10.1016/j.it.2019.09.004	Trends in Immunology 40/11	2020-04-07
2018	Daniel J. Kunz, TomÃ¡s Gomes, Kylie R. James Immune Cell Dynamics Unfolded by Single-Cell Technologies published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01435	Frontiers in Immunology 9	2020-04-07
2018	Ekaterina Minskaia, Barbara C. Saraiva, Maria M. V. Soares, Rita I. Azevedo, Ruy M. Ribeiro, Saumya D. Kumar, Ana I. S. Vieira, JoÃ£o F. Lacerda Molecular Markers Distinguishing T Cell Subtypes With TSDR Strand-Bias Methylation published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02540	Frontiers in Immunology 9	2020-04-07
2018	Lina Petersone, Natalie M. Edner, Vitalijs Ovcinnikovs, Frank Heuts, Ellen M. Ross, Elisavet Ntavli, Chun J. Wang, Lucy S. K. Walker T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01941	Frontiers in Immunology 9	2020-04-07
2019	Thomas Faux, Kalle T. RytkÃ¶nen, Asta Laiho, Laura L. Elo RepViz: a replicate-driven R tool for visualizing genomic regions published pages: , ISSN: 1756-0500, DOI: 10.1186/s13104-019-4473-z	BMC Research Notes 12/1	2020-04-07
2018	Marisa Stebegg, Saumya D. Kumar, Alyssa Silva-Cayetano, Valter R. Fonseca, Michelle A. Linterman, Luis Graca Regulation of the Germinal Center Response published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02469	Frontiers in Immunology 9	2020-04-07
2018	Jhuma Pramanik, Xi Chen, Gozde Kar, Johan Henriksson, TomÃ¡s Gomes, Jong-Eun Park, Kedar Natarajan, Kerstin B. Meyer, Zhichao Miao, Andrew N. J. McKenzie, Bidesh Mahata, Sarah A. Teichmann Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation published pages: , ISSN: 1756-994X, DOI: 10.1186/s13073-018-0589-3	Genome Medicine 10/1	2020-04-07
2017	Tomi Suomi, Fatemeh Seyednasrollah, Maria K. Jaakkola, Thomas Faux, Laura L. Elo ROTS: An R package for reproducibility-optimized statistical testing published pages: e1005562, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1005562	PLOS Computational Biology 13/5	2020-04-07
2017	Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen Cellular Stress in the Context of an Inflammatory Environment Supports TGF-Î²-Independent T Helper-17 Differentiation published pages: 2357-2370, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.05.052	Cell Reports 19/11	2020-04-07
2019	Marisa Stebegg, Alyssa Silva-Cayetano, Silvia Innocentin, Timothy P. Jenkins, Cinzia Cantacessi, Colin Gilbert, Michelle A. Linterman Heterochronic faecal transplantation boosts gut germinal centres in aged mice published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10430-7	Nature Communications 10/1	2020-04-07
2019	Vitalijs Ovcinnikovs, Ellen M. Ross, Lina Petersone, Natalie M. Edner, Frank Heuts, Elisavet Ntavli, Alexandros Kogimtzis, Alan Kennedy, Chun Jing Wang, Clare L. Bennett, David M. Sansom, Lucy S. K. Walker CTLA-4â€“mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells published pages: eaaw0902, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aaw0902	Science Immunology 4/35	2020-04-07

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