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PAINSTRAT SIGNED

Novel neurophysiological techniques to quantify pain and stratify patients

Total Cost €

EC-Contrib. €

Partnership

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PAINSTRAT project word cloud

Explore the words cloud of the PAINSTRAT project. It provides you a very rough idea of what is the project "PAINSTRAT" about.

15 signals treatments longitudinally goals identification stratification critically electrophysiological drugs neuronal dramatic diagnosis effort gt pattern transduction 250 mechanisms bns nociceptive federation translation least treatment 200 positively biomarker perception strategies spontaneous patients constitute changed neurophysiological types little pain patient alone expression clinical quantification risk volunteers insights date trials molecular breakthrough despite analgesic prevention biomarkers medicine gene genes laboratory neurological satisfied spectacular mechanistic last transmission personalised confident burden susceptibility healthy society techniques efficacious chronic

Project "PAINSTRAT" data sheet

The following table provides information about the project.

Coordinator	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	1˙627˙825 €
EC max contribution	1˙627˙825 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	coordinator	795˙132.00
2	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	832˙692.00

Map

Project objective

In the last 15 years the advances in understanding the molecular mechanisms of pain have been spectacular. However, despite the >200 genes identified and the dramatic insights on transduction and transmission of nociceptive signals, very little has changed in the diagnosis and treatment of pain, at least in terms of analgesic drugs. Therefore, pain remains a major burden for the society (chronic pain alone costs the EU >€250 bns/yr). The reason is that pain is not a pattern of gene expression, but a state of neuronal activity. Therefore, the translation of mechanistic insights into effective treatments will depend critically on a better understanding of the electrophysiological changes that occur. For this reason, the European Federation of Neurological Society has called for a particular effort to identify reliable laboratory measures of pain, and having an objective biomarker for pain quantification and patient stratification would constitute a major breakthrough in medicine. To date, this need has not been satisfied. The project has two main objectives: (1) Developing neurophysiological biomarkers of pain perception: the main aim being quantification of spontaneous pain for patient management and clinical trials. (2) Developing neurophysiological biomarkers of the susceptibility to develop chronic pain: the main aim being patient stratification, development of prevention strategies, and personalised medicine for pain. We will apply novel analysis techniques to the neurophysiological information obtained using a range of techniques from a large number of healthy volunteers and patients with different types of chronic pain. Importantly, we will longitudinally study patients at high risk of developing chronic pain. We are fully confident that these goals - early diagnosis, identification of high risk patients and facilitating the development of new efficacious treatments through useful clinical trials - will positively impact the well-being of chronic pain patients.

Publications

List of publications.
year	authors and title	journal	last update
2018	AndrÃ© Mouraux, Gian Domenico Iannetti The search for pain biomarkers in the human brain published pages: 3290-3307, ISSN: 0006-8950, DOI: 10.1093/brain/awy281	Brain 141/12	2019-05-20
2018	M. Algoet, J. Duque, G.D. Iannetti, A. Mouraux Temporal Profile and Limb-specificity of Phasic Pain-Evoked Changes in Motor Excitability published pages: 240-255, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2018.06.039	Neuroscience 386	2019-05-20
2018	Flavia Mancini, Alessia Pepe, Alberto Bernacchia, Giulia Di Stefano, AndrÃ© Mouraux, Gian Domenico Iannetti Characterizing the Short-Term Habituation of Event-Related Evoked Potentials published pages: ENEURO.0014-18.2, ISSN: 2373-2822, DOI: 10.1523/ENEURO.0014-18.2018	eneuro 5/5	2019-05-20
2016	Li Hu, Gian Domenico Iannetti Painful Issues in Pain Prediction published pages: 212-220, ISSN: 0166-2236, DOI: 10.1016/j.tins.2016.01.004	Trends in Neurosciences 39/4	2019-05-20
2017	R. J. Bufacchi, C. F. Sambo, G. Di Stefano, G. Cruccu, G. D. Iannetti Pain outside the body: defensive peripersonal space deformation in trigeminal neuralgia published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12466-5	Scientific Reports 7/1	2019-05-20
2018	Giacomo Novembre, Vijay M. Pawar, Rory J. Bufacchi, Marina Kilintari, Mandayam Srinivasan, John C. Rothwell, Patrick Haggard, Gian Domenico Iannetti Saliency Detection as a Reactive Process: Unexpected Sensory Events Evoke Corticomuscular Coupling published pages: 2385-2397, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2474-17.2017	The Journal of Neuroscience 38/9	2019-05-20
2018	E. R. FerrÃ¨, G. D. Iannetti, J. A. van Dijk, P. Haggard Ineffectiveness of tactile gating shows cortical basis of nociceptive signaling in the Thermal Grill Illusion published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24635-1	Scientific Reports 8/1	2019-05-20
2018	Weiwei Peng, Xiaolei Xia, Ming Yi, Gan Huang, Zhiguo Zhang, Giandomenico Iannetti, Li Hu Brain oscillations reflecting pain-related behavior in freely moving rats published pages: 106-118, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001069	PAIN 159/1	2019-05-20
2018	Q.Q. Jin, G.Q. Wu, W.W. Peng, X.L. Xia, L. Hu, G.D. Iannetti Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents published pages: 5538-5550, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.3654-17.2018	The Journal of Neuroscience 38/24	2019-05-20
2017	Karen D. Davis, Herta Flor, Henry T. Greely, Gian Domenico Iannetti, Sean Mackey, Markus Ploner, Amanda Pustilnik, Irene Tracey, Rolf-Detlef Treede, Tor D. Wager Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations published pages: 624-638, ISSN: 1759-4758, DOI: 10.1038/nrneurol.2017.122	Nature Reviews Neurology 13/10	2019-05-20
2016	Rory John Bufacchi, Gian Domenico Iannetti Gravitational cues modulate the shape of defensive peripersonal space published pages: R1133-R1134, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.09.025	Current Biology 26/21	2019-06-07
2016	Flavia Mancini, Karina Dolgevica, James Steckelmacher, Patrick Haggard, Karl Friston, Giandomenico D. Iannetti Perceptual learning to discriminate the intensity and spatial location of nociceptive stimuli published pages: , ISSN: 2045-2322, DOI: 10.1038/srep39104	Scientific Reports 6/1	2019-06-07
2016	Tim V. Salomons, Gian Domenico Iannetti, Meng Liang, John N. Wood The â€œPain Matrixâ€ in Pain-Free Individuals published pages: 755, ISSN: 2168-6149, DOI: 10.1001/jamaneurol.2016.0653	JAMA Neurology 73/6	2019-06-07
2016	M. Liang, M. C. Lee, J. O\'Neill, A. H. Dickenson, G. D. Iannetti Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways published pages: 286-295, ISSN: 0022-3077, DOI: 10.1152/jn.00013.2016	Journal of Neurophysiology 116/2	2019-06-07
2016	M. Moayedi, G. Di Stefano, M. T. Stubbs, B. Djeugam, M. Liang, G. D. Iannetti Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates published pages: , ISSN: 2373-2822, DOI: 10.1523/ENEURO.0151-15.2016	eNeuro 3/3	2019-06-07
2016	Tor D. Wager, Lauren Y. Atlas, Matthew M. Botvinick, Luke J. Chang, Robert C. Coghill, Karen Deborah Davis, Gian Domenico Iannetti, Russell A. Poldrack, Alexander J. Shackman, Tal Yarkoni Pain in the ACC? published pages: E2474-E2475, ISSN: 0027-8424, DOI: 10.1073/pnas.1600282113	Proceedings of the National Academy of Sciences 113/18	2019-06-07

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