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ALKATRAS SIGNED

ALK Activation as a target of TRAanslational Science (ALKATRAS): Break free from cancer

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ALKATRAS project word cloud

Explore the words cloud of the ALKATRAS project. It provides you a very rough idea of what is the project "ALKATRAS" about.

laboratories alk cohort balanced mechanistic mechanisms prominent committee sectors train prevalent cosset plan translational conducts pharma 15 eria 13 lymphoma groups erialcl exposed competence forefront toxic international participation panel multidisciplinary interface therapies generation excellent skills anaplastic tissuegnostics integrating cambridge primary perform independent fellows sciences science net stage phd clinical etn recruited academic broaden oncogenic varionostics competent fellow competitive scientists incorporated local training supervised transferable oncogene thereby instigated efficacious human individual bio calibre recognised connected roche network complemented perspectives career confident secondments galkem coordinate functional poses coordinated personal malignancies nurture environment internationally sofigen biomedical courses life kinase collaborative guided environments smes

Project "ALKATRAS" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://alkatras.erialcl.net
Total cost	3˙849˙199 €
EC max contribution	3˙849˙199 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2019-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	546˙575.00
2	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	574˙216.00
3	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	525˙751.00
4	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	263˙659.00
5	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	258˙061.00
6	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: 20126 website: www.unimib.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	258˙061.00
7	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	249˙216.00
8	EBERHARD KARLS UNIVERSITAET TUEBINGEN EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	249˙216.00
9	JUSTUS-LIEBIG-UNIVERSITAET GIESSEN JUSTUS-LIEBIG-UNIVERSITAET GIESSEN Organization address address: LUDWIGSTRASSE 23 city: GIESSEN postcode: 35390 website: www.uni-giessen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GIESSEN)	participant	249˙216.00
10	UNIVERSITAETSKLINIKUM FREIBURG UNIVERSITAETSKLINIKUM FREIBURG Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	participant	249˙216.00
11	Masarykova univerzita Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	participant	232˙422.00
12	LUDWIG BOLTZMANN GESELLSCHAFT GMBH LUDWIG BOLTZMANN GESELLSCHAFT GMBH Organization address address: NUSSDORFER STRASSE 64 6 STOCK city: WIEN postcode: 1090 website: www.lbg.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	193˙585.00
13	INSTITUT GUSTAVE ROUSSY INSTITUT GUSTAVE ROUSSY Organization address address: Rue Camille Desmoulins 39 city: VILLEJUIF postcode: 94805 website: http://www.igr.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	0.00
14	BIOLUTION GMBH BIOLUTION GMBH Organization address address: HELMUT QUALTINGER GASSE 2/2 city: WIEN postcode: 1030 website: www.biolution.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	partner	0.00
15	Cambridge Life sciences Cambridge Life sciences Organization address address: n.a. city: Cambridge postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cambridge)	partner	0.00
16	Central European Society of Anti-Cancer Research (CESAR) Central European Society of Anti-Cancer Research (CESAR) Organization address address: HANGLUSSGASSE 4 1 3 city: WIEN postcode: 1150 website: www.cesar.or.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	partner	0.00
17	GALKEM SRL GALKEM SRL Organization address address: VIA ITALIA 46 city: Monza postcode: 20900 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Monza)	partner	0.00
18	MEDIZINISCHE UNIVERSITAT GRAZ MEDIZINISCHE UNIVERSITAT GRAZ Organization address address: AUENBRUGGERPLATZ 2 city: GRAZ postcode: 8036 website: http://www.medunigraz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	partner	0.00
19	Roche Austria Roche Austria Organization address address: Engelhorngasse 3 city: Vienna postcode: 1211 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (Vienna)	partner	0.00
20	Sofigen Sofigen Organization address address: n.a. city: Brno postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (Brno)	partner	0.00
21	The Naked Scientists The Naked Scientists Organization address address: West Green, Barrington 36 city: Cambridge postcode: CB22 7SA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cambridge)	partner	0.00
22	TISSUEGNOSTICS GMBH TISSUEGNOSTICS GMBH Organization address address: TABORSTRASSE 10/2 city: VIENNA postcode: 1020 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (VIENNA)	partner	0.00
23	VARIONOSTIC GMBH VARIONOSTIC GMBH Organization address address: SOFLINGER STRASSE 100 city: ULM postcode: 89077 website: www.varionostic.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ULM)	partner	0.00

Map

Project objective

This ETN is embedded into an established international research programme; The European Research Initiative on Anaplastic Lymphoma Kinase (ALK)-related malignancies (ERIA; www.erialcl.net) is an existing and functional network of 13 partners, which will cosset and nurture a cohort of early stage researchers to become confident, competent, independent and well-connected European scientists with excellent career perspectives. ERIA was instigated to coordinate research into ALK-related malignancies to facilitate the development of less-toxic and more efficacious therapies. ALK is increasingly recognised as a prevalent oncogene in a number of human malignancies and therefore poses a prominent clinical problem, which requires coordinated research into its oncogenic mechanisms. ERIA now conducts a collaborative multidisciplinary research programme at the interface of biomedical and bio-mechanistic approaches, which will be an excellent environment to train the next generation of European scientists. The 15 recruited fellows will be incorporated into international academic study groups (all partners of the ERIA network) to perform high calibre research and also will be exposed to environments from other sectors to broaden their experience. Secondments will include technical training within individual laboratories and SMEs (TissueGnostics, Galkem, Cambridge Life Sciences, Sofigen and Varionostics) as well as large Pharma (Roche). Training through research will be complemented with a balanced programme of transferable skills and access to local courses. The training of each fellow will be guided by a personal career development plan and supervised by a PhD committee panel. The primary goal of the network is to train the recruited fellows by participation in an internationally competitive research programme and integrating them into an international network. Thereby providing competence in state-of-the-art research and development at the forefront of translational science.

Deliverables

List of deliverables.
ALCL transcriptome database	Websites, patent fillings, videos etc.	2020-04-16 14:19:29
ALKATRAS website developed and updated	Websites, patent fillings, videos etc.	2020-04-16 14:19:40
Therapy Synergism database	Websites, patent fillings, videos etc.	2020-04-16 14:19:34

Take a look to the deliverables list in detail: detailed list of ALKATRAS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Geeta Sharma, Ines Mota, Luca Mologni, Enrico Patrucco, Carlo Gambacorti-Passerini, Roberto Chiarle Tumor Resistance against ALK Targeted Therapy-Where It Comes From and Where It Goes published pages: 62, ISSN: 2072-6694, DOI: 10.3390/cancers10030062	Cancers 10/3	2019-07-09
2018	Ricky Trigg, Suzanne Turner ALK in Neuroblastoma: Biological and Therapeutic Implications published pages: 113, ISSN: 2072-6694, DOI: 10.3390/cancers10040113	Cancers 10/4	2019-07-09
2018	Ines Garces de los Fayos Alonso, Huan-Chang Liang, Suzanne Turner, Sabine Lagger, Olaf Merkel, Lukas Kenner The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas published pages: 93, ISSN: 2072-6694, DOI: 10.3390/cancers10040093	Cancers 10/4	2019-07-09
2018	Cosimo Lobello, Vasilis Bikos, Andrea Janikova, Sarka Pospisilova The Role of Oncogenic Tyrosine Kinase NPM-ALK in Genomic Instability published pages: 64, ISSN: 2072-6694, DOI: 10.3390/cancers10030064	Cancers 10/3	2019-07-09
2018	Nina Prokoph, Hugo Larose, Megan Lim, G. Burke, Suzanne Turner Treatment Options for Paediatric Anaplastic Large Cell Lymphoma (ALCL): Current Standard and beyond published pages: 99, ISSN: 2072-6694, DOI: 10.3390/cancers10040099	Cancers 10/4	2019-07-09
2018	Ivonne Montes-Mojarro, Julia Steinhilber, Irina Bonzheim, Leticia Quintanilla-Martinez, Falko Fend The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL) published pages: 107, ISSN: 2072-6694, DOI: 10.3390/cancers10040107	Cancers 10/4	2019-07-09
2018	Serena Stadler, Vijay Singh, Fabian KnÃ¶rr, Christine Damm-Welk, Wilhelm Woessmann Immune Response against ALK in Children with ALK-Positive Anaplastic Large Cell Lymphoma published pages: 114, ISSN: 2072-6694, DOI: 10.3390/cancers10040114	Cancers 10/4	2019-07-09
2016	MelanieÂ R. Hassler, Walter Pulverer, Ranjani Lakshminarasimhan, Elisa Redl, Julia Hacker, GavinÂ D. Garland, Olaf Merkel, Ana-Iris Schiefer, Ingrid Simonitsch-Klupp, Lukas Kenner, DanielÂ J. Weisenberger, Andreas Weinhaeusel, SuzanneÂ D. Turner, Gerda Egger Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling published pages: 596-608, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.09.018	Cell Reports 17/2	2019-09-04
2018	Nikolai Schleussner, Olaf Merkel, Mariantonia Costanza, Huan-Chang Liang, Franziska Hummel, Chiara Romagnani, Pawel Durek, Ioannis Anagnostopoulos, Michael Hummel, Korinna JÃ¶hrens, Antonia Niedobitek, Patrick R. Griffin, Roberto Piva, Henrike L. Sczakiel, Wilhelm Woessmann, Christine Damm-Welk, Christian Hinze, Dagmar Stoiber, Bernd Gillissen, Suzanne D. Turner, Eva Kaergel, Linda von Hoff, Michael Grau, Georg Lenz, Bernd DÃ¶rken, Claus Scheidereit, Lukas Kenner, Martin Janz, Stephan Mathas The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma published pages: 1994-2007, ISSN: 0887-6924, DOI: 10.1038/s41375-018-0045-9	Leukemia 32/9	2019-07-09
2018	Rafael B. Blasco, Enrico Patrucco, Ines Mota, Wei-Tien Tai, Roberto Chiarle Comment on â€œALK is a therapeutic target for lethal sepsisâ€ published pages: eaar4321, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aar4321	Science Translational Medicine 10/471	2019-07-09
2019	Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, AndrÃ©a Melis, Tiffany Martin, Lin Xia, Heng Yang, Qingqing Li, Jinfeng Chen, SylvÃ¨re Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bongers, Veronique Minard-Colin, Eric Tartour, Laurence Zitvogel, Lionel Apetoh, Yuting Ma, Mikael J. Pittet, Oliver Kepp, Guido Kroemer Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09838-y	Nature Communications 10/1	2019-07-09
2019	Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Than Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta KitzwÃ¶gerer, Andreas Chott, Andrea Janikova, Å Ã¡rka PospÃÅ¡ilova, Joanna I. Loizou, Stefan Kubicek, Peter Valent, Thomas Kolbe, Florian Grebien, Lukas Kenner, Patrick T. Gunning, Robert Kralovics, Marco Herling, Mathias MÃ¼ller, Thomas RÃ¼licke, Veronika Sexl, Richard Moriggl High activation of STAT5A drives peripheral T-cell lymphoma and leukemia published pages: haematol.2019.21, ISSN: 0390-6078, DOI: 10.3324/haematol.2019.216986	Haematologica	2019-07-09
2019	Matteo Menotti, Chiara Ambrogio, Taek-Chin Cheong, Chiara Pighi, Ines Mota, Seth H. Cassel, Mara Compagno, Qi Wang, Riccardo Dallâ€™Olio, Valerio G. Minero, Teresa Poggio, Geeta Geeta Sharma, Enrico Patrucco, Cristina Mastini, Ramesh Choudhari, Achille Pich, Alberto Zamo, Roberto Piva, Silvia Giliani, Luca Mologni, Clayton K. Collings, Cigall Kadoch, Carlo Gambacorti-Passerini, Luigi D. Notarangelo, Ines M. Anton, Claudia Voena, Roberto Chiarle Wiskottâ€“Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma published pages: 130-140, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0262-9	Nature Medicine 25/1	2019-07-09
2019	Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, AndrÃ©a Melis, Tiffany Martin, Lin Xia, Heng Yang, Qingqing Li, Jinfeng Chen, SylvÃ¨re Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bongers, Veronique Minard-Colin, Eric Tartour, Laurence Zitvogel, Lionel Apetoh, Yuting Ma, Mikael J. Pittet, Oliver Kepp, Guido Kroemer Crizotinib-induced immunogenic cell death in non-small cell lung cancer published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09415-3	Nature Communications 10/1	2019-07-09
2018	Alessandro Prestipino, Alica J. Emhardt, Konrad Aumann, David Oâ€™Sullivan, Sivahari P. Gorantla, Sandra Duquesne, Wolfgang Melchinger, Lukas Braun, Slavica Vuckovic, Melanie Boerries, Hauke Busch, Sebastian Halbach, Sandra Pennisi, Teresa Poggio, Petya Apostolova, Pia Veratti, Michael Hettich, Gabriele Niedermann, Mark BartholomÃ¤, Khalid Shoumariyeh, Jonas S. Jutzi, Julius Wehrle, Christine Dierks, Heiko Becker, Annette Schmitt-Graeff, Marie Follo, Dietmar Pfeifer, Jan Rohr, Sebastian Fuchs, Stephan Ehl, Frederike A. Hartl, Susana Minguet, Cornelius Miething, Florian H. Heidel, Nicolaus KrÃ¶ger, Ioanna Triviai, Tilman Brummer, JÃ¼rgen Finke, Anna L. Illert, Eliana Ruggiero, Chiara Bonini, Justus Duyster, Heike L. Pahl, Steven W. Lane, Geoffrey R. Hill, Bruce R. Blazar, Nikolas von Bubnoff, Erika L. Pearce, Robert Zeiser Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms published pages: eaam7729, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aam7729	Science Translational Medicine 10/429	2019-07-09
2019	Nicole Prutsch, Elisabeth Gurnhofer, Tobias Suske, Huan Chang Liang, Michaela Schlederer, Simone Roos, Lawren C. Wu, Ingrid Simonitsch-Klupp, Andrea Alvarez-Hernandez, Christoph Kornauth, Dario A. Leone, Jasmin Svinka, Robert Eferl, Tanja Limberger, Astrid Aufinger, Nitesh Shirsath, Peter Wolf, Thomas Hielscher, Fritz Aberger, Johannes Schmoellerl, Dagmar Stoiber, Birgit Strobl, Ulrich JÃ¤ger, Philipp B. Staber, Florian Grebien, Richard Moriggl, Mathias MÃ¼ller, Giorgio G. Inghirami, Takaomi Sanda, A. Thomas Look, Suzanne D. Turner, Lukas Kenner, Olaf Merkel Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma published pages: 696-709, ISSN: 0887-6924, DOI: 10.1038/s41375-018-0239-1	Leukemia 33/3	2019-07-09
2018	Luca Mologni, Mariantonia Costanza, Geeta Geeta Sharma, Michela Viltadi, Luca Massimino, Stefania Citterio, Stefania Purgante, Hima Raman, Alessandra Pirola, Massimo Zucchetti, Rocco Piazza, Carlo Gambacorti-Passerini Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells published pages: 467-477, ISSN: 1476-5586, DOI: 10.1016/j.neo.2018.02.009	Neoplasia 20/5	2019-07-09
2017	Julie Frentzel, Domenico Sorrentino, Sylvie Giuriato Targeting Autophagy in ALK-Associated Cancers published pages: 161, ISSN: 2072-6694, DOI: 10.3390/cancers9120161	Cancers 9/12	2019-07-09

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The information about "ALKATRAS" are provided by the European Opendata Portal: CORDIS opendata.