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PROFILE SIGNED

Innovative training network: Immunoprofile-directed stratification of patients with the autoimmune disorder thrombotic thrombocytopenic purpura

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PROFILE project word cloud

Explore the words cloud of the PROFILE project. It provides you a very rough idea of what is the project "PROFILE" about.

network clinical beneficiary innovative bioassays clinic academic thrombocytopenic flexible companies scientifically purpura transfer either training commercializing intersectoral stratification emphasizes disease tools platforms stage industrial ttp thrombotic force personalized driving medicine patients translational molecular boost human follow organization profile patient trained biomarkers endowing academia disorder technologies advancing autoimmune acquired therapeutics doctoral disorders diagnostics

Project "PROFILE" data sheet

The following table provides information about the project.

Coordinator	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://www.itn-profile.eu
Total cost	1˙464˙397 €
EC max contribution	1˙464˙397 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-EID
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	coordinator	501˙120.00
2	Stichting Sanquin Bloedvoorziening Stichting Sanquin Bloedvoorziening Organization address address: Plesmanlaan 125 city: Amsterdam postcode: 1006 AN website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Amsterdam)	participant	510˙748.00
3	ICOSAGEN AS ICOSAGEN AS Organization address address: NOORUSE 9 city: TARTU postcode: 50411 website: www.icosagen.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	226˙264.00
4	PROTOBIOS OU PROTOBIOS OU Organization address address: MAEALUSE 4 city: TALLINN postcode: 12618 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TALLINN)	participant	226˙264.00
5	ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ASSISTANCE PUBLIQUE HOPITAUX DE PARIS Organization address address: 3 AVENUE VICTORIA city: PARIS postcode: 75000 website: http://www.aphp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	partner	0.00
6	Biokit Biokit Organization address address: CAN MALÉ S/N city: LLIÇA D´AMUNT postcode: 8186 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LLIÇA D´AMUNT)	partner	0.00
7	Dutch TTP patient organization Dutch TTP patient organization Organization address address: n.a. city: Hoogland postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Hoogland)	partner	0.00
8	EUROPEAN HEMATOLOGY ASSOCIATION EUROPEAN HEMATOLOGY ASSOCIATION Organization address address: KONINGINNEGRACHT 12B/13 city: DEN HAAG postcode: 2514 AA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DEN HAAG)	partner	0.00
9	Immudex Aps Immudex Aps Organization address address: Fruebjergvej 3 city: Copenhagen postcode: 2100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (Copenhagen)	partner	0.00

Map

Project objective

The PROFILE Innovative European Industrial Doctoral programme will develop improved tools for stratification of patients with the autoimmune disorder acquired thrombotic thrombocytopenic purpura (TTP). Patient stratification is needed in order to further develop personalized medicine approaches for human disorders. Therefore, a detailed understanding of the disease at the molecular level is needed. Furthermore, implementation of a robust set of novel biomarkers is essential for stratification of patients. Also, highly flexible platforms to rapidly develop novel therapeutics are crucial to further boost the field of personalized medicine. The research program is embedded in a unique translational training program, which emphasizes clinical needs as a driving force for development of novel, innovative diagnostics and therapeutics (for personalized medicine). There is intersectoral knowledge transfer between academia and companies at the European level as 6 different EU Member states are involved in the network either as beneficiary or partner organization. The PROFILE network will allow 6 early stage researchers to follow this unique translational training. They will be trained in the clinic to identify clinical needs, in academia where they will contribute to a scientifically ambitious project and in the non-academic sector where they will be trained in a novel technologies and commercializing bioassays endowing them with an unique PROFILE for further advancing personalized medicine in Europe.

Deliverables

List of deliverables.
Scientific WP(1-4).6	Other	2020-02-12 16:53:57
Training 5.4	Other	2020-02-07 12:50:52
Scientific WP(1-4).2	Documents, reports	2020-02-07 12:50:50
Scientific WP(1-4).5	Other	2020-02-07 12:50:54
Scientific WP(1-4).3	Documents, reports	2020-02-07 12:50:54
Scientific WP(1-4).4	Other	2020-02-07 12:50:55
Communication 6.1	Websites, patent fillings, videos etc.	2019-07-09 17:09:32
Training 5.3	Other	2019-07-09 17:09:32

Take a look to the deliverables list in detail: detailed list of PROFILE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Kanin Wichapong, Hessel Poelman, Bogac Ercig, Johana Hrdinova, Xiaosong Liu, Esther Lutgens, Gerry AF Nicolaes Rational modulator design by exploitation of proteinâ€“protein complex structures published pages: 1015-1033, ISSN: 1756-8919, DOI: 10.4155/fmc-2018-0433	Future Medicinal Chemistry 11/9	2019-10-03
2019	Anastasis Petri, Hyo Jung Kim, Yaoxian Xu, Rens de Groot, Chan Li, Aline Vandenbulcke, Karen Vanhoorelbeke, Jonas Emsley, James T. B. Crawley Crystal structure and substrate-induced activation of ADAMTS13 published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11474-5	Nature Communications 10/1	2019-10-03
2019	Lara Zafrani, Charlotte Dekimpe, BÃ©rangÃ¨re. S. Joly, Elien Roose, Fabienne Fieux, Elie Azoulay, Marie-NoÃ«lle Peraldi, Antoine Durrbach, Paul Coppo, Karen Vanhoorelbeke, AgnÃ¨s Veyradier Transfer of ADAMTS13 antibody-mediated thrombotic thrombocytopenic purpura via kidney transplantation published pages: e277-e280, ISSN: 0390-6078, DOI: 10.3324/haematol.2019.219063	Haematologica 104/6	2019-10-03
2018	BÃ©rangÃ¨re S. Joly, X. Long Zheng, AgnÃ¨s Veyradier Understanding thrombotic microangiopathies in children published pages: 1536-1538, ISSN: 0342-4642, DOI: 10.1007/s00134-018-5059-2	Intensive Care Medicine 44/9	2019-10-03
2018	Bogac Ercig, Kanin Wichapong, Chris Reutelingsperger, Karen Vanhoorelbeke, Jan Voorberg, Gerry Nicolaes Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura published pages: 028-041, ISSN: 0340-6245, DOI: 10.1160/th17-06-0404	Thrombosis and Haemostasis 118/01	2019-07-09
2018	E. Roose, A. S. Schelpe, B. S. Joly, M. Peetermans, P. Verhamme, J. Voorberg, A. Greinacher, H. Deckmyn, S. F. De Meyer, P. Coppo, A. Veyradier, K. Vanhoorelbeke An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura published pages: 378-388, ISSN: 1538-7933, DOI: 10.1111/jth.13922	Journal of Thrombosis and Haemostasis 16/2	2019-07-09
2018	BÃ©rangÃ¨re Joly, Pierre Boisseau, Elien Roose, Alain Stepanian, Nathalie Biebuyck, Julien Hogan, FranÃ§ois Provot, Yahsou Delmas, CÃ©line Garrec, Karen Vanhoorelbeke, Paul Coppo, AgnÃ¨s Veyradier ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshawâ€“Schulman Syndrome published pages: 1902-1917, ISSN: 0340-6245, DOI: 10.1055/s-0038-1673686	Thrombosis and Haemostasis 118/11	2019-07-09
2018	Johana HrdinovÃ¡, Fabian C. Verbij, Paul H.P. Kaijen, Robin B. Hartholt, Floris van Alphen, Neubury Lardy, Anja ten Brinke, Karen Vanhoorelbeke, Pooja J. Hindocha, Anne S. De Groot, Alexander B. Meijer, Jan Voorberg, Ivan Peyron Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ published pages: 1083-1092, ISSN: 0390-6078, DOI: 10.3324/haematol.2017.179119	Haematologica 103/6	2019-07-09
2018	Johana HrdinovÃ¡, Silvia Dâ€™Angelo, Nuno A. G. GraÃ§a, Bogac Ercig, Karen Vanhoorelbeke, AgnÃ¨s Veyradier, Jan Voorberg, Paul Coppo Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers published pages: 1099-1109, ISSN: 0390-6078, DOI: 10.3324/haematol.2016.151407	Haematologica 103/7	2019-07-09
2018	Matthieu Jestin, Ygal Benhamou, An-Sofie Schelpe, Elien Roose, FranÃ§ois ProvÃ´t, Lionel Galicier, Miguel HiÃ©, Claire Presne, Pascale Poullin, Alain Wynckel, Samir Saheb, Christophe Deligny, Aude Servais, StÃ©phane Girault, Yahsou Delmas, Tarik Kanouni, Alexandre Lautrette, Dominique Chauveau, Christiane Mousson, Pierre Perez, Jean-Michel Halimi, Anne Charvet-Rumpler, Mohamed Hamidou, Pascal CathÃ©bras, Karen Vanhoorelbeke, AgnÃ¨s Veyradier, Paul Coppo Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura published pages: 2143-2153, ISSN: 0006-4971, DOI: 10.1182/blood-2018-04-840090	Blood 132/20	2019-07-09
2018	An-Sofie Schelpe, Christelle Orlando, Bogac Ercig, ChloÃ« Geeroms, Inge Pareyn, Nele Vandeputte, Leydi Carolina VelÃ¡squez Pereira, Elien Roose, Karel Fostier, Gerry A.F. Nicolaes, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke, Kristin Jochmans Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13 published pages: 191-199, ISSN: 0902-4441, DOI: 10.1111/ejh.13094	European Journal of Haematology 101/2	2019-07-09
2018	Elien Roose, Gestur Vidarsson, Kadri Kangro, Onno Verhagen, Ilaria Mancini, Linda Desender, Inge Pareyn, Nele Vandeputte, Aline Vandenbulcke, Chiara Vendramin, An-Sofie Schelpe, Jan Voorberg, Marie-AgnÃ¨s Azerad, Laurent Gilardin, Marie Scully, Daan Dierickx, Hans Deckmyn, Simon De Meyer, Flora Peyvandi, Karen Vanhoorelbeke Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura published pages: 1729-1742, ISSN: 0340-6245, DOI: 10.1055/s-0038-1669459	Thrombosis and Haemostasis 118/10	2019-07-09
2017	Johanna A. Kremer Hovinga, Paul Coppo, Bernhard LÃ¤mmle, Joel L. Moake, Toshiyuki Miyata, Karen Vanhoorelbeke Thrombotic thrombocytopenic purpura published pages: 17020, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.20	Nature Reviews Disease Primers 3	2019-07-09
2017	BÃ©rangÃ¨re S. Joly, Karen Vanhoorelbeke, AgnÃ¨s Veyradier Understanding therapeutic targets in thrombotic thrombocytopenic purpura published pages: 1398-1400, ISSN: 0342-4642, DOI: 10.1007/s00134-016-4662-3	Intensive Care Medicine 43/9	2019-07-09
2017	Ralf J. Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M. McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M. Hammers, Jon M. Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Rudolf A. Manz, Falk Nimmerjahn Mechanisms of Autoantibody-Induced Pathology published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00603	Frontiers in Immunology 8	2019-07-09

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