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HisMoDetect

An Antibody Microarray for Histone Modifications

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HisMoDetect project word cloud

Explore the words cloud of the HisMoDetect project. It provides you a very rough idea of what is the project "HisMoDetect" about.

drug    cellular    polyribosylation    chromatin    local    epigenetic    translational    heterochromatic    rendering    fast    levels    post    suppressed    core    h2b    gene    residues    tissue    biological    cell    binding    vital    eukaryotic    monitor    division    serve    histones    intensive    western    drugs    developmental    silencing    believe    phosphorylation    screening    recognize    dna    h2a    of    dozens    dictate    epigentic    copies    microarray    subject    landscape    multiple    tails    structural    recruitment    active    form    prognosis    variety    regulatory    expression    antibody    histone    essentially    ubiquitination    modifications    euchromatic    associate    indirect    diagnosis    h4    protrude    genomic    procedure    nucleosome    decondensed    methylation    compact    acetylation    consuming    labour    direct    mechanisms    sumoylation    platform    structure    blot    time    global    proteins    suggest    simultaneously    programs    companies    basic    h3   

Project "HisMoDetect" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 150˙000.00

Map

 Project objective

Histones are the major structural proteins of eukaryotic DNA. Two copies each of the core histones, H2A, H2B, H3 and H4, form the core nucleosome, the basic unit of chromatin. Histone tails protrude from the nucleosome structure and are subject to a variety of post-translational modifications on multiple residues, including methylation, acetylation, phosphorylation, sumoylation, ubiquitination and polyribosylation. These histone modifications dictate local and global structure of chromatin, rendering it active and decondensed (‘euchromatic’) or suppressed and compact (‘heterochromatic’) by the recruitment of chromatin-binding proteins that recognize and associate with specific modifications. Histone modifications are therefore the basic regulatory unit of gene expression, genomic silencing, developmental programs, cell division and essentially all cellular processes. Understanding this so-called ‘epigenetic’ landscape is therefore vital for all biological mechanisms. Currently a Western blot is required in order to determine the state of each of the dozens of different histone modifications. Because of the growing number of histone modifications, this procedure is time consuming and labour intensive. Here I suggest to develop an antibody microarray to monitor the levels of all histone modifications simultaneously. This method will be essentially useful for any tissue or cell type in any biological process, for diagnosis, prognosis and drug screening. In addition to basic research, our platform will enable fast and reliable screening for epigenetic effects of existing and novel drugs. We believe that such a product could serve many drug companies interested in direct and indirect effects of epigenetic and non-epigentic drugs.

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The information about "HISMODETECT" are provided by the European Opendata Portal: CORDIS opendata.

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