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HisMoDetect

An Antibody Microarray for Histone Modifications

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HisMoDetect project word cloud

Explore the words cloud of the HisMoDetect project. It provides you a very rough idea of what is the project "HisMoDetect" about.

expression    consuming    heterochromatic    procedure    active    genomic    recognize    believe    cellular    h4    silencing    global    residues    antibody    cell    epigentic    sumoylation    variety    binding    structure    multiple    levels    landscape    polyribosylation    h3    subject    dozens    proteins    histone    suggest    microarray    copies    dna    platform    protrude    biological    h2b    modifications    core    decondensed    monitor    epigenetic    local    methylation    eukaryotic    prognosis    acetylation    associate    gene    translational    vital    essentially    of    tissue    nucleosome    rendering    phosphorylation    euchromatic    drug    indirect    regulatory    screening    post    tails    western    intensive    dictate    companies    histones    fast    ubiquitination    suppressed    developmental    structural    time    drugs    chromatin    labour    form    division    programs    compact    diagnosis    serve    basic    blot    simultaneously    direct    mechanisms    recruitment    h2a   

Project "HisMoDetect" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 150˙000.00

Map

 Project objective

Histones are the major structural proteins of eukaryotic DNA. Two copies each of the core histones, H2A, H2B, H3 and H4, form the core nucleosome, the basic unit of chromatin. Histone tails protrude from the nucleosome structure and are subject to a variety of post-translational modifications on multiple residues, including methylation, acetylation, phosphorylation, sumoylation, ubiquitination and polyribosylation. These histone modifications dictate local and global structure of chromatin, rendering it active and decondensed (‘euchromatic’) or suppressed and compact (‘heterochromatic’) by the recruitment of chromatin-binding proteins that recognize and associate with specific modifications. Histone modifications are therefore the basic regulatory unit of gene expression, genomic silencing, developmental programs, cell division and essentially all cellular processes. Understanding this so-called ‘epigenetic’ landscape is therefore vital for all biological mechanisms. Currently a Western blot is required in order to determine the state of each of the dozens of different histone modifications. Because of the growing number of histone modifications, this procedure is time consuming and labour intensive. Here I suggest to develop an antibody microarray to monitor the levels of all histone modifications simultaneously. This method will be essentially useful for any tissue or cell type in any biological process, for diagnosis, prognosis and drug screening. In addition to basic research, our platform will enable fast and reliable screening for epigenetic effects of existing and novel drugs. We believe that such a product could serve many drug companies interested in direct and indirect effects of epigenetic and non-epigentic drugs.

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The information about "HISMODETECT" are provided by the European Opendata Portal: CORDIS opendata.

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