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FRAGNET SIGNED

FRAGments training NETwork

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FRAGNET project word cloud

Explore the words cloud of the FRAGNET project. It provides you a very rough idea of what is the project "FRAGNET" about.

academic weight chemistry fragments pathophysiological emerged companies possibilities fragnet transferable optimisation protein training consists hit discovery train scientific leads sciences view 15 transfer drug holistic prominent sensitive biophysical mainly compounds performed fuelling nature jointly event provides entrepreneurship skill fbld specialised molecular quality pharmaceutical facets obtain groups writing multidisciplinary enthusiasm esrs technologies area committed biochemical capture missing network binding skills fragment interactions thorough combined small excel biology media interface shaped efficient chemical public smes affinity detect screening difficult promise rational private biotech

Project "FRAGNET" data sheet

The following table provides information about the project.

Coordinator	STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://fragnet.eu/
Total cost	3˙842˙481 €
EC max contribution	3˙842˙481 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	1˙021˙497.00
2	UNIVERSITY OF YORK UNIVERSITY OF YORK Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD website: http://www.york.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (YORK NORTH YORKSHIRE)	participant	819˙863.00
3	UNIVERSITAT DE BARCELONA UNIVERSITAT DE BARCELONA Organization address address: GRAN VIA DE LES CORTS CATALANES 585 city: BARCELONA postcode: 8007 website: http://www.ub.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	495˙745.00
4	TERMESZETTUDOMANYI KUTATOKOZPONT TERMESZETTUDOMANYI KUTATOKOZPONT Organization address address: MAGYAR TUDOSOK KORUTJA 2 city: BUDAPEST postcode: 1117 website: www.ttk.mta.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	447˙827.00
5	VERNALIS (R&D) LIMITED VERNALIS (R&D) LIMITED Organization address address: GRANTA PARK GREAT ABINGTON city: CAMBRIDGE postcode: CB21 6GB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	273˙287.00
6	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	265˙226.00
7	BEACTICA THERAPEUTICS AB BEACTICA THERAPEUTICS AB Organization address address: VIRDINGS ALLE 2 city: UPPSALA postcode: 754 50 website: www.beactica.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	263˙659.00
8	ZOBIO BV ZOBIO BV Organization address address: J.H. OORTWEG 19 city: LEIDEN postcode: 2333 CH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	255˙374.00
9	24 Media Labs 24 Media Labs Organization address address: Vasteland 78 city: Rotterdam postcode: 3011 BN website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Rotterdam)	partner	0.00
10	F. HOFFMANN-LA ROCHE AG F. HOFFMANN-LA ROCHE AG Organization address address: GRENZACHERSTRASSE 124 city: BASEL postcode: 4070 website: www.roche.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	partner	0.00
11	GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. Organization address address: Great West Road 980 city: BRENTFORD postcode: TW89GS website: www.gsk.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRENTFORD)	partner	0.00
12	INSTITUT DE RECHERCHES SERVIER INSTITUT DE RECHERCHES SERVIER Organization address address: 3 Rue de la Republique city: SURESNES postcode: 92150 website: www.servier.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SURESNES)	partner	0.00
13	IOTA Pharmaceuticals Ltd IOTA Pharmaceuticals Ltd Organization address address: COWLEY ROAD ST JOHNS INNOVATION CENTRE city: CAMBRIDGE postcode: CB4 0WS website: www.iotapharma.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	partner	0.00

Map

Project objective

The promise of more efficient lead discovery is fuelling the enthusiasm for fragment-based lead discovery (FBLD). In this approach, highly sensitive biochemical and biophysical screening technologies are being used to detect the low affinity binding of low molecular weight compounds (the so-called fragments) to protein targets that are involved in pathophysiological processes. By investigating the molecular interactions between fragment hit(s) and the target protein, a detailed understanding of the binding event is obtained. This enables the rational and efficient optimisation of the hit fragment. The optimised compounds represent high quality leads for drug development. The necessary FBLD technologies and approaches have emerged mainly from small and specialised biotech companies. At present, FBLD is being adopted throughout pharmaceutical sciences, including by pharmaceutical companies, SMEs and academic research groups. So far, the necessary training that is needed to obtain an holistic view of the possibilities and opportunities that FBLD provides is missing, most likely because the highly multidisciplinary nature of the FBLD work is difficult to capture within one (academic) institute. Therefore, we have established FragNet as a dedicated FBLD training network. The consortium consists of the most prominent pharmaceutical companies, biotech companies and academic groups that have jointly shaped the FBLD research area. FragNet is committed to train 15 ESRs in all facets of FBLD using the combined technologies, skills and knowledge. This will include both research (e.g., technologies on the interface of chemistry and biology) and transferable skill sets (e.g., writing, media training, entrepreneurship and thorough understanding of scientific knowledge transfer). This will enable the ESRs to excel in today’s drug discovery and chemical biology programmes that are performed in public and private organisations in the pharmaceutical sciences.

Deliverables

List of deliverables.
Open meetings organised	Other	2020-04-24 23:22:35
FragNet website	Websites, patent fillings, videos etc.	2020-04-09 09:21:05

Take a look to the deliverables list in detail: detailed list of FRAGNET deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Maciej Majewski, Sergio Ruiz-Carmona, Xavier Barril An investigation of structural stability in protein-ligand complexes reveals the balance between order and disorder published pages: , ISSN: 2399-3669, DOI: 10.1038/s42004-019-0205-5	Communications Chemistry 2/1	2020-04-09
2018	Moira M Rachman, Xavier Barril, Roderick E Hubbard Predicting how drug molecules bind to their protein targets published pages: 34-39, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.07.001	Current Opinion in Pharmacology 42	2020-04-09
2018	PÃ©ter ÃbrÃ¡nyi-Balogh, LÃ¡szlÃ³ Petri, TÃmea Imre, PÃ©ter Szijj, Andrea Scarpino, Martina Hrast, Ana MitroviÄ‡, UrÅ¡a PeÄar FonoviÄ, Krisztina NÃ©meth, HÃ©lÃ¨ne Barreteau, David I. Roper, Kata HorvÃ¡ti, GyÃ¶rgy G. Ferenczy, Janko Kos, Janez IlaÅ¡, Stanislav Gobec, GyÃ¶rgy M. KeserÅ± A road map for prioritizing warheads for cysteine targeting covalent inhibitors published pages: 94-107, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.10.010	European Journal of Medicinal Chemistry 160	2020-04-09
2018	Angelo K.S. Romasanta, Peter van der Sijde, Iina Hellsten, Roderick E. Hubbard, Gyorgy M. Keseru, Jacqueline van Muijlwijk-Koezen, Iwan J.P. de Esch When fragments link: a bibliometric perspective on the development of fragment-based drug discovery published pages: 1596-1609, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2018.05.004	Drug Discovery Today 23/9	2020-04-09
2019	Scarpino, Bajusz, Proj, Gobec, SosiÄ, Gobec, Ferenczy, KeserÅ± Discovery of Immunoproteasome Inhibitors Using Large-Scale Covalent Virtual Screening published pages: 2590, ISSN: 1420-3049, DOI: 10.3390/molecules24142590	Molecules 24/14	2020-04-09
2018	Andrea Scarpino, GyÃ¶rgy G. Ferenczy, GyÃ¶rgy M. KeserÅ± Comparative Evaluation of Covalent Docking Tools published pages: 1441-1458, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.8b00228	Journal of Chemical Information and Modeling 58/7	2020-04-09
2018	Aaron Keeley, PÃ©ter ÃbrÃ¡nyi-Balogh, Martina Hrast, TÃmea Imre, Janez IlaÅ¡, Stanislav Gobec, GyÃ¶rgy M. KeserÅ± Heterocyclic electrophiles as new MurA inhibitors published pages: 1800184, ISSN: 0365-6233, DOI: 10.1002/ardp.201800184	Archiv der Pharmazie 351/12	2020-04-09
2018	Bas Lamoree, Roderick E. Hubbard Using Fragment-Based Approaches to Discover New Antibiotics published pages: 495-510, ISSN: 2472-5552, DOI: 10.1177/2472555218773034	SLAS DISCOVERY: Advancing the Science of Drug Discovery 23/6	2020-04-09
2019	Moira Rachman, Andrea Scarpino, DÃ¡vid Bajusz, Gyula PÃ¡lfy, IstvÃ¡n Vida, AndrÃ¡s Perczel, Xavier Barril, GyÃ¶rgy M. KeserÅ± DUckCov: a Dynamic Undockingâ€Based Virtual Screening Protocol for Covalent Binders published pages: 1011-1021, ISSN: 1860-7179, DOI: 10.1002/cmdc.201900078	ChemMedChem 14/10	2020-04-09

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The information about "FRAGNET" are provided by the European Opendata Portal: CORDIS opendata.