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RuMicroPlas SIGNED

The Plasmidome: a Driving Force of Rumen Microbial Evolution from Birth to Adulthood

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

RuMicroPlas project word cloud

Explore the words cloud of the RuMicroPlas project. It provides you a very rough idea of what is the project "RuMicroPlas" about.

communities evolution relationships resolution effect genome evolutionary bacterial gene understand sampling dense bears host ruminants assembly interactions time dependence complement confined edge overview genes contributors microbial perfect interaction ecology plasmidome community entities single played cutting ecosystem place physiology adult rumen individual provides ecological poorly vehicles nature global fine co house phenotypes population insights explore obligatory genomes plasmid details plasmids dynamics lateral compartment goals assemblages perspectives origins local examine digestive transfer microbiome centric tract

Project "RuMicroPlas" data sheet

The following table provides information about the project.

Coordinator	BEN-GURION UNIVERSITY OF THE NEGEV Organization address address: . city: BEER SHEVA postcode: 84105 website: www.bgu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	1˙499˙000 €
EC max contribution	1˙499˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BEN-GURION UNIVERSITY OF THE NEGEV BEN-GURION UNIVERSITY OF THE NEGEV Organization address address: . city: BEER SHEVA postcode: 84105 website: www.bgu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (BEER SHEVA)	coordinator	1˙499˙000.00

Map

Project objective

Plasmids are known to be major contributors to lateral gene transfer in bacterial genomes; however, their comprehensive evolutionary role within bacterial communities is poorly understood. Recently we have developed cutting edge abilities to access a plasmid population (plasmidome) of a given microbial community, and applied them to rumen microbial communities. These abilities are an element long-needed for the study of microbial lateral gene transfer and evolution. Ruminants house a highly complex microbial community in the rumen compartment of their digestive tract, with which they have evolved into an obligatory co-dependence. Its confined nature provides a perfect system for the study of evolutionary dynamics within microbial communities. Here we propose to study the evolutionary and ecological dynamics of the rumen plasmidome and its interaction with the rumen microbiome using our established approaches, together with a dense host-sampling resolution. We aim to understand the origins and assembly of these two entities, as well as their interactions with each other. We will explore the effect of early assemblages on the adult plasmidome and microbiome phenotypes. To complement the overview of global trends, we will study local interactions among individual rumen plasmids with their microbial host's genome and physiology at the single-plasmid level. These two distinct perspectives will allow us to understand the role played by plasmids within this complex microbial community, the co-evolutionary relationships between these two entities and their importance to the overall rumen ecosystem. Based on a plasmid-centric approach, this study bears the unique ability to examine lateral gene transfer in “real time” by following genes on their transfer “vehicles”, and providing new insights into the fine details of microbial evolution. Its goals, many challenges and new approach place this proposal at the cutting edge of current research in microbial ecology and evolution.

Publications

List of publications.
year	authors and title	journal	last update
2017	Goor Sasson, Sheerli Kruger Ben-Shabat, Eyal Seroussi, Adi Doron-Faigenboim, Naama Shterzer, Shamay Yaacoby, Margret E. Berg Miller, Bryan A. White, Eran Halperin, Itzhak Mizrahi Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cowâ€™s Capacity To Harvest Energy from Its Feed published pages: , ISSN: 2150-7511, DOI: 10.1128/mBio.00703-17	mBio 8/4	2019-04-18
2016	Roye Rozov, Aya Brown Kav, David Bogumil, Naama Shterzer, Eran Halperin, Itzhak Mizrahi, Ron Shamir Recycler: an algorithm for detecting plasmids from de novo assembly graphs published pages: btw651, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btw651	Bioinformatics	2019-04-18
2018	Yoav Shaani, Tamar Zehavi, Stav Eyal, Joshuah Miron, Itzhak Mizrahi Microbiome niche modification drives diurnal rumen community assembly, overpowering individual variability and diet effects published pages: 2446-2457, ISSN: 1751-7362, DOI: 10.1038/s41396-018-0203-0	The ISME Journal 12/10	2019-04-18
2016	Sheerli Kruger Ben Shabat, Goor Sasson, Adi Doron-Faigenboim, Thomer Durman, Shamay Yaacoby, Margret E Berg Miller, Bryan A White, Naama Shterzer, Itzhak Mizrahi Specific microbiome-dependent mechanisms underlie the energy harvest efficiency of ruminants published pages: 2958-2972, ISSN: 1751-7362, DOI: 10.1038/ismej.2016.62	The ISME Journal 10/12	2019-04-18
2018	Fotini Kokou, Goor Sasson, Tali Nitzan, Adi Doron-Faigenboim, Sheenan Harpaz, Avner Cnaani, Itzhak Mizrahi Host genetic selection for cold tolerance shapes microbiome composition and modulates its response to temperature published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.36398	eLife 7	2019-04-18
2019	Sarah MoraÃ¯s, Itzhak Mizrahi The Road Not Taken: The Rumen Microbiome, Functional Groups, and Community States published pages: , ISSN: 0966-842X, DOI: 10.1016/j.tim.2018.12.011	Trends in Microbiology	2019-02-26

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