StemNicheOnWaveCrest SIGNED
New therapies for myeloproliferative diseases based on multi-stage and -system analyses of the haematopoietic stem-cell niche
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0StemNicheOnWaveCrest project word cloud
Explore the words cloud of the StemNicheOnWaveCrest project. It provides you a very rough idea of what is the project "StemNicheOnWaveCrest" about.
Project "StemNicheOnWaveCrest" data sheet
The following table provides information about the project.
| Coordinator |
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙594˙500 € |
| EC max contribution | 1˙594˙500 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE | UK (CAMBRIDGE) | coordinator | 1˙594˙500.00 |
Map
Project objective
Blood cells are produced in the bone marrow, which contains two distinct adult stem cell types: haematopoietic stem cells (HSCs), that generate all blood and immune cells, and mesenchymal stem cells (MSCs), thought to form the skeleton. HSCs traffic between bone marrow and circulation, what allows for life-saving clinical transplantation. Our previous work has shown that HSC numbers in blood are regulated by the central pacemaker in the brain, which reaches bone marrow nestin MSCs through the nerves. Contrarily to what it was believed, our recent data suggest that HSC-niche MSCs are different from those that form the skeleton and share instead a common origin with peripheral nerves and supporting glial cells. Thus, tight regulation of the bone marrow stem-cell niche in vertebrates might build upon developmental relationships of its cellular components. Moreover, we have shown that damage to this regulatory network is essential for the manifestation of myeloproliferative neoplasms, diseases that were previously thought to be driven solely by mutated HSCs. Also, JAK inhibitors (blocking the most frequent HSC mutation found in myeloproliferative neoplasms) cannot eradicate leukaemia stem cells. Our recent data has uncovered a selective regulation of normal and leukaemic haematopoietic progenitor maintenance, survival and division by sex hormones (oestrogens). These results might explain gender differences in blood cancer incidence and they also offer a new way of targeting leukaemia stem cells with clinically approved drugs. Nevertheless, we anticipate that the ideal future treatment of myeloproliferative diseases should target both leukaemia stem cells and their microenvironment. We have shown that protection or rescue of the niche is able to control the expansion of mutated cells. We aim to study this novel neuroendocrine regulation of bone marrow stem cells that will potentially fructify in new therapies for incurable myeloproliferative diseases.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Simón Méndez-Ferrer, Dominique Bonnet, David P. Steensma, Robert P. Hasserjian, Irene M. Ghobrial, John G. Gribben, Michael Andreeff , Daniela S. Krause Bone marrow niches in haematological malignancies published pages: , ISSN: 1474-175X, DOI: 10.1038/s41568-020-0245-2 |
Nature Reviews Cancer | 2020-03-11 |
| 2020 |
Ya-Hsuan Ho, Simón Méndez-Ferrer Microenvironmental contributions to hematopoietic stem cell aging published pages: 38-46, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.211334 |
Haematologica 105/1 | 2020-03-11 |
| 2019 |
David Ramos, Joana Catita, Mariana López-Luppo, Andreia Valença, Aina Bonet, Ana Carretero, Marc Navarro, Victor Nacher, Simon Mendez-Ferrer, Anna Meseguer, Alba Casellas, LuÃsa Mendes-Jorge, Jesús Ruberte Vascular Interstitial Cells in Retinal Arteriolar Annuli Are Altered During Hypertension published pages: 473, ISSN: 1552-5783, DOI: 10.1167/iovs.18-25000 |
Investigative Opthalmology & Visual Science 60/2 | 2020-03-11 |
| 2019 |
Mehmet Saçma, Johannes Pospiech, Ruzhica Bogeska, Walter de Back, Jan-Philipp Mallm, Vadim Sakk, Karin Soller, Gina Marka, Angelika Vollmer, Rebekah Karns, Nina Cabezas-Wallscheid, Andreas Trumpp, Simón Méndez-Ferrer, Michael D. Milsom, Medhanie A. Mulaw, Hartmut Geiger, Maria Carolina Florian Haematopoietic stem cells in perisinusoidal niches are protected from ageing published pages: 1309-1320, ISSN: 1465-7392, DOI: 10.1038/s41556-019-0418-y |
Nature Cell Biology 21/11 | 2020-03-11 |
| 2018 |
Karin Golan, Anju Kumari, Orit Kollet, Eman Khatib-Massalha, Mohana Devi Subramaniam, Zulma S. Ferreira, Francesca Avemaria, Sylwia Rzeszotek, Andrés GarcÃa-GarcÃa, Stephanie Xie, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Tomer Itkin, Aya Ludin-Tal, Hassan Massalha, Biana Bernshtein, Andrzej K. Ciechanowicz, Alexander Brandis, Tevie Mehlman, Suditi Bhattacharya, Mayla Bertagna, Hui Cheng, Ekate Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance published pages: 572-585.e7, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.08.002 |
Cell Stem Cell 23/4 | 2020-03-11 |
| 2019 |
Simón Méndez-Ferrer Molecular interactome between HSCs and their niches published pages: 1197-1198, ISSN: 0006-4971, DOI: 10.1182/blood.2019002615 |
Blood 134/15 | 2020-03-11 |
| 2019 |
Ya-Hsuan Ho, Raquel del Toro, José Rivera-Torres, Justyna Rak, Claudia Korn, Andrés GarcÃa-GarcÃa, David MacÃas, Cristina González-Gómez, Alberto del Monte, Monika Wittner, Amie K. Waller, Holly R. Foster, Carlos López-OtÃn, Randall S. Johnson, Claus Nerlov, Cedric Ghevaert, William Vainchenker, Fawzia Louache, Vicente Andrés, Simón Méndez-Ferrer Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging published pages: 407-418.e6, ISSN: 1934-5909, DOI: 10.1016/j.stem.2019.06.007 |
Cell Stem Cell 25/3 | 2020-03-11 |
| 2019 |
Dorian Forte, Daniela S. Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer Updates on the hematologic tumor microenvironment and its therapeutic targeting published pages: 1928-1934, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.195396 |
Haematologica 104/10 | 2020-03-11 |
| 2019 |
Beatrice Drexler, Jakob R. Passweg, Alexandar Tzankov, Martin Bigler, Alexandre PA Theocharides, Nathan Cantoni, Peter Keller, Georg Stussi, Axel Ruefer, Rudolf Benz, Geneviève Favre, Pontus Lundberg, Ronny Nienhold, Andrea Fuhrer, Christine Biaggi, Markus G. Manz, Mario Bargetzi, Simon Mendez-Ferrer, Radek C. Skoda The sympathomimetic agonist mirabegron did not lower JAK2 -V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14 published pages: 710-716, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.200014 |
Haematologica 104/4 | 2020-03-11 |
| 2019 |
Andrés GarcÃa-GarcÃa, Claudia Korn, MarÃa GarcÃa-Fernández, Olivia Domingues, Javier Villadiego, Daniel MartÃn-Pérez, Joan Isern, José A. Bejarano-GarcÃa, Jacques Zimmer, José A. Pérez-Simón, Juan J. Toledo-Aral, Tatiana Michel, Matti S. Airaksinen, Simón Méndez-Ferrer Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes published pages: 224-236, ISSN: 0006-4971, DOI: 10.1182/blood-2018-08-867648 |
Blood 133/3 | 2020-01-15 |
| 2017 |
Anna Merlo, Cristóbal Bernardo-Castiñeira, Inés Sáenz-de-Santa-MarÃa, Ana S Pitiot, Milagros BalbÃn, Aurora Astudillo, Nuria Valdés, Bartolomé Scola, Raquel Del Toro, Simón Méndez-Ferrer, José I Piruat, Carlos Suarez, MarÃa-Dolores Chiara Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.14265 |
Oncotarget 8/4 | 2020-01-15 |
| 2017 |
Abel Sánchez-Aguilera, Simón Méndez-Ferrer The hematopoietic stem-cell niche in health and leukemia published pages: 579-590, ISSN: 1420-682X, DOI: 10.1007/s00018-016-2306-y |
Cellular and Molecular Life Sciences 74/4 | 2020-01-15 |
| 2016 |
A. Engert, C. Balduini, A. Brand, B. Coiffier, C. Cordonnier, H. Dohner, T. D. de Wit, S. Eichinger, W. Fibbe, T. Green, F. de Haas, A. Iolascon, T. Jaffredo, F. Rodeghiero, G. Salles, J. J. Schuringa, J. J. Schuringa, T. Jaffredo, B. Coiffier, G. Salles, H. Dohner, A. Iolascon, C. Balduini, S. Eichinger, A. Brand, C. Cordonnier, W. Fibbe The European Hematology Association Roadmap for European Hematology Research: a consensus document published pages: 115-208, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.136739 |
Haematologica 101/2 | 2020-01-15 |
| 2016 |
Justyna Rak, Simón Méndez-Ferrer T-ALL: several homes rather than homeless? published pages: 1-2, ISSN: 0818-9641, DOI: 10.1038/icb.2016.103 |
Immunology and Cell Biology 95/1 | 2020-01-15 |
| 2018 |
Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, LÃvia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06069-5 |
Nature Communications 9/1 | 2020-01-15 |
| 2017 |
Simón Méndez-Ferrer Human and mouse leukocytes: different clockwork published pages: 1960-1961, ISSN: 0006-4971, DOI: 10.1182/blood-2017-09-805374 |
Blood 130/18 | 2020-01-15 |
| 2017 |
Claudia Korn, Simón Méndez-Ferrer Myeloid malignancies and the microenvironment published pages: 811-822, ISSN: 0006-4971, DOI: 10.1182/blood-2016-09-670224 |
Blood 129/7 | 2020-01-15 |
| 2016 |
MarÃa GarcÃa-Fernández, Simón Méndez-Ferrer Under Pressure: When a Transformed Environment Pushes Cells to Malignancy published pages: 559-560, ISSN: 1934-5909, DOI: 10.1016/j.stem.2016.10.012 |
Cell Stem Cell 19/5 | 2020-01-15 |
| 2016 |
Raquel del Toro, Raphael Chèvre, Cristina RodrÃguez, Antonio Ordóñez, José MartÃnez-González, Vicente Andrés, Simón Méndez-Ferrer Nestin+ cells direct inflammatory cell migration in atherosclerosis published pages: 12706, ISSN: 2041-1723, DOI: 10.1038/ncomms12706 |
Nature Communications 7 | 2020-01-15 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STEMNICHEONWAVECREST" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "STEMNICHEONWAVECREST" are provided by the European Opendata Portal: CORDIS opendata.