Explore the words cloud of the FORCE project. It provides you a very rough idea of what is the project "FORCE" about.
The following table provides information about the project.
Coordinator |
KING'S COLLEGE LONDON
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://www.force-imaging.org |
Total cost | 7˙418˙116 € |
EC max contribution | 5˙812˙631 € (78%) |
Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
Code Call | H2020-PHC-2015-two-stage |
Funding Scheme | RIA |
Starting year | 2016 |
Duration (year-month-day) | from 2016-01-01 to 2020-09-30 |
Take a look of project's partnership.
Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo. Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumour’s metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging . We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.
Report on clinical MRF protocol for breast | Documents, reports | 2020-04-07 20:29:54 |
Take a look to the deliverables list in detail: detailed list of FORCE deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Daniel Fovargue, David Nordsletten, Ralph Sinkus Stiffness reconstruction methods for MR elastography published pages: e3935, ISSN: 0952-3480, DOI: 10.1002/nbm.3935 |
NMR in Biomedicine 31/10 | 2020-04-07 |
2019 |
Samuel Patz, Daniel Fovargue, Katharina Schregel, Navid Nazari, Miklos Palotai, Paul E. Barbone, Ben Fabry, Alexander Hammers, Sverre Holm, Sebastian Kozerke, David Nordsletten, Ralph Sinkus Imaging localized neuronal activity at fast time scales through biomechanics published pages: eaav3816, ISSN: 2375-2548, DOI: 10.1126/sciadv.aav3816 |
Science Advances 5/4 | 2020-04-07 |
2018 |
Daniel Fovargue, Sebastian Kozerke, Ralph Sinkus, David Nordsletten Robust MR elastography stiffness quantification using a localized divergence free finite element reconstruction published pages: 126-142, ISSN: 1361-8415, DOI: 10.1016/j.media.2017.12.005 |
Medical Image Analysis 44 | 2020-04-07 |
2016 |
Vikash Pandey and Sverre Holm Linking the fractional derivative and the Lomnitz creep law to non-Newtonian time-varying viscosity published pages: 32606, ISSN: 2470-0045, DOI: 10.1103/PhysRevE.94.032606 |
Physical Review E Vol. 94, Issue 3 | 2020-04-07 |
2016 |
Stefan Hetzer, Patric Birr, Andreas Fehlner, Sebastian Hirsch, Florian Dittmann, Eric Barnhill, Jürgen Braun, Ingolf Sack Perfusion alters stiffness of deep gray matter published pages: 0271678X1769153, ISSN: 0271-678X, DOI: 10.1177/0271678X17691530 |
Journal of Cerebral Blood Flow & Metabolism | 2020-04-07 |
2018 |
Christian Guenthner, Sebastian Kozerke Encoding and readout strategies in magnetic resonance elastography published pages: e3919, ISSN: 0952-3480, DOI: 10.1002/nbm.3919 |
NMR in Biomedicine 31/10 | 2020-04-07 |
2018 |
Guenthner, Christian; Runge, Jurgen Henk; Sinkus, Ralph; Kozerke, Sebastian Analysis and improvement of motion encoding in magnetic resonance elastography published pages: , ISSN: 0952-3480, DOI: 10.5167/uzh-159366 |
Guenthner, Christian; Runge, Jurgen Henk; Sinkus, Ralph; Kozerke, Sebastian (2018). Analysis and improvement of motion encoding in magnetic resonance elastography. NMR in Biomedicine, 31(5):e3908. 1 | 2020-04-07 |
2017 |
Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs Jamming transitions in cancer published pages: 483001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aa8e83 |
Journal of Physics D: Applied Physics 50/48 | 2020-04-07 |
2018 |
Claudia Tanja Mierke, Frank Sauer, Steffen Grosser, Stefanie Puder, Tony Fischer, Josef Alfons Käs The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle published pages: e3831, ISSN: 0952-3480, DOI: 10.1002/nbm.3831 |
NMR in Biomedicine 31/10 | 2020-04-07 |
2018 |
Jin Li, Konstantinos Zormpas-Petridis, Andreas Heindl, Jessica K.R. Boult, Craig Cummings, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson Collagen is a major determinant of the viscoelasticity properties of stromal dense tumours: insights from pre-clinical MRE published pages: \"Abstr #629\", ISSN: , DOI: |
Proceedings of the Annual Meeting of the International Society for Magnetic Resonance in Medicine | 2020-04-07 |
2018 |
Emma Reeves, Jin Li, Konstantinos Zormpas-Petridis, Andreas Heindl, Jessica K.R. Boult, Craig Cummings, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson Stiffness, measured by magnetic resonance elastography (MRE), correlates with collagen content in stromal dense tumours published pages: , ISSN: , DOI: |
Forces in Cancer: interdisciplinary approaches in tumour mechanobiology | 2020-04-07 |
2017 |
James P. B. O\'Connor, Eric O. Aboagye, Judith E. Adams, Hugo J. W. L. Aerts, Sally F. Barrington, Ambros J. Beer, Ronald Boellaard, Sarah E. Bohndiek, Michael Brady, Gina Brown, David L. Buckley, Thomas L. Chenevert, Laurence P. Clarke, Sandra Collette, Gary J. Cook, Nandita M. deSouza, John C. Dickson, Caroline Dive, Jeffrey L. Evelhoch, Corinne Faivre-Finn, Ferdia A. Gallagher, Fiona J. Gilbert, Robert J. Gillies, Vicky Goh, John R. Griffiths, Ashley M. Groves, Steve Halligan, Adrian L. Harris, David J. Hawkes, Otto S. Hoekstra, Erich P. Huang, Brian F. Hutton, Edward F. Jackson, Gordon C. Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O. Leach, Ting-Yim Lee, Edward L. Leen, Jason S. Lewis, Yan Liu, Mark F. Lythgoe, Prakash Manoharan, Ross J. Maxwell, Kenneth A. Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R. Padhani, Geoff J. M. Parker, Mike Partridge, Arvind P. Pathak, Andrew C. Peet, Shonit Punwani, Andrew R. Reynolds, Simon P. Robinson, Lalitha K. Shankar, Ricky A. Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C. Sullivan, Stuart A. Taylor, Paul S. Tofts, Gillian M. Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J. Williams, Paul Workman, Thomas E. Yankeelov, Kevin M. Brindle, Lisa M. McShane, Alan Jackson, John C. Waterton Imaging biomarker roadmap for cancer studies published pages: 169-186, ISSN: 1759-4774, DOI: 10.1038/nrclinonc.2016.162 |
Nature Reviews Clinical Oncology 14/3 | 2020-04-07 |
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