Explore the words cloud of the EHVA project. It provides you a very rough idea of what is the project "EHVA" about.
The following table provides information about the project.
Coordinator |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Organization address contact info |
Coordinator Country | France [FR] |
Project website | http://www.ehv-a.eu/ |
Total cost | 28˙135˙596 € |
EC max contribution | 22˙188˙521 € (79%) |
Programme |
1. H2020-EU.3.1.2. (Preventing disease) |
Code Call | H2020-PHC-2015-single-stage_RTD |
Funding Scheme | RIA |
Starting year | 2016 |
Duration (year-month-day) | from 2016-01-01 to 2020-12-31 |
Take a look of project's partnership.
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the European HIV Vaccine Alliance (EHVA) program will develop a Multidisciplinary Vaccine Platform (MVP) in the fields of prophylactic and therapeutic HIV vaccines. The Specific Objectives of the MVP are to build up: 1.Discovery Platform with the goal of generating novel vaccine candidates inducing potent neutralizing and non-neutralizing antibody responses and T-cell responses, 2. Immune Profiling Platform with the goal of ranking novel and existing (benchmark) vaccine candidates on the basis of the immune profile, 3. Data Management/Integration/Down-Selection Platform, with the goal of providing statistical tools for the analysis and interpretation of complex data and algorithms for the efficient selection of vaccines, and 4. Clinical Trials Platform with the goal of accelerating the clinical development of novel vaccines and the early prediction of vaccine failure. EHVA project has developed a global and innovative strategy which includes: a) the multidisciplinary expertise involving immunologists, virologists, structural biology experts, statisticians and computational scientists and clinicians; b) the most innovative technologies to profile immune response and virus reservoir; c) the access to large cohort studies bringing together top European clinical scientists/centres in the fields of prophylactic and therapeutic vaccines, d) the access to a panel of experimental HIV vaccines under clinical development that will be used as benchmark, and e) the liaison to a number of African leading scientists/programs which will foster the testing of future EHVA vaccines through EDCTP
Draft EHVA dissemination and exploitation plan | Websites, patent fillings, videos etc. | 2019-11-27 17:18:40 |
EHVA website and branding launched | Websites, patent fillings, videos etc. | 2019-11-27 17:18:40 |
First EHVA newsletter and fact sheet developed and published | Websites, patent fillings, videos etc. | 2019-11-27 17:18:40 |
Take a look to the deliverables list in detail: detailed list of EHVA deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Melanie Wittner, Veronika Schlicker, Jana Libera, Jan-Hendrik Bockmann, Thomas Horvatits, Oliver Seiz, Silke Kummer, Carolin F. Manthey, Anja Hüfner, Marcus Kantowski, Thomas Rösch, Olaf Degen, Samuel Huber, Johanna M. Eberhard, Julian Schulze zur Wiesch Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis published pages: e0220008, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0220008 |
PLOS ONE 14/7 | 2020-03-05 |
2019 |
Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Sorzano, Lidia Saiz, Pilar Mediavilla, Mariano Esteban, Carmen Gómez A Novel MVA-Based HIV Vaccine Candidate (MVA-gp145-GPN) Co-Expressing Clade C Membrane-Bound Trimeric gp145 Env and Gag-Induced Virus-Like Particles (VLPs) Triggered Broad and Multifunctional HIV-1-Specific T Cell and Antibody Responses published pages: 160, ISSN: 1999-4915, DOI: 10.3390/v11020160 |
Viruses 11/2 | 2020-03-05 |
2019 |
Yuka Nadai, Kathrin Held, Sarah Joseph, Mohamed I. M. Ahmed, Verena S. Hoffmann, David Peterhoff, Marco Missanga, Asli Bauer, Agricola Joachim, Ulf Reimer, Johannes Zerweck, Sheena McCormack, Alethea V. Cope, Roger Tatoud, Robin J. Shattock, Merlin Lee Robb, Eric G. Sandstroem, Michael Hoelscher, Leonard Maboko, Muhammad Bakari, Arne Kroidl, Ralf Wagner, Jonathan Weber, Georgios Pollakis, Christof Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00717 |
Frontiers in Immunology 10 | 2020-03-05 |
2019 |
Beatriz Perdiguero, Carmen Elena Gómez, Juan GarcÃa-Arriaza, Cristina Sánchez-Corzo, Carlos Óscar S. Sorzano, Sarah Wilmschen, Dorothee von Laer, Benedikt Asbach, Christina Schmalzl, David Peterhoff, Song Ding, Ralf Wagner, Janine Kimpel, Yves Levy, Giuseppe Pantaleo, Mariano Esteban Heterologous Combination of VSV-GP and NYVAC Vectors Expressing HIV-1 Trimeric gp145 Env as Vaccination Strategy to Induce Balanced B and T Cell Immune Responses published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02941 |
Frontiers in Immunology 10 | 2020-03-05 |
2019 |
Sarah Wilmschen, Joern E. Schmitz, Janine Kimpel Viral Vectors for the Induction of Broadly Neutralizing Antibodies against HIV published pages: 119, ISSN: 2076-393X, DOI: 10.3390/vaccines7030119 |
Vaccines 7/3 | 2020-03-05 |
2019 |
Suresh C. Raman, Ernesto MejÃas-Pérez, Carmen E. Gomez, Juan GarcÃa-Arriaza, Beatriz Perdiguero, Aneesh Vijayan, Mar Pérez-Ruiz, Ana Cuervo, César Santiago, Carlos Oscar S. Sorzano, Cristina Sánchez-Corzo, Christiane Moog, Judith A. Burger, Anna Schorcht, Rogier W. Sanders, José L. Carrascosa, Mariano Esteban The Envelope-Based Fusion Antigen GP120C14K Forming Hexamer-Like Structures Triggers T Cell and Neutralizing Antibody Responses Against HIV-1 published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02793 |
Frontiers in Immunology 10 | 2020-03-05 |
2019 |
Patricia Pérez, MarÃa Q. MarÃn, Adrián Lázaro-FrÃas, Carlos Óscar S. Sorzano, Mauro Di Pilato, Carmen E. Gómez, Mariano Esteban, Juan GarcÃa-Arriaza An MVA Vector Expressing HIV-1 Envelope under the Control of a Potent Vaccinia Virus Promoter as a Promising Strategy in HIV/AIDS Vaccine Design published pages: 208, ISSN: 2076-393X, DOI: 10.3390/vaccines7040208 |
Vaccines 7/4 | 2020-03-05 |
2019 |
C. Bresk, Tamara Hofer, Sarah Wilmschen, Marina Krismer, Anja Beierfuß, Grégory Effantin, Winfried Weissenhorn, Michael Hogan, Andrea Jordan, Rebecca Gelman, David Montefiori, Hua-Xin Liao, Joern Schmitz, Barton Haynes, Dorothee von Laer, Janine Kimpel Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector published pages: 159, ISSN: 1999-4915, DOI: 10.3390/v11020159 |
Viruses 11/2 | 2020-03-05 |
2017 |
Peterhoff D, Wagner R Guiding the long way to neutralization published pages: , ISSN: 1746-630X, DOI: |
Current Oppinion in HIV and AIDS | 2019-11-27 |
2016 |
Benjamin Zimmer, Veronika Grassmann, Tim-Henrik Bruun, Thomas Schubert, Anna Gabele, Alexander Kliche and Ralf Wagner Identification of novel HIV-1 vaccine candidates using mammalian cell-surface display and FACS panning published pages: , ISSN: , DOI: |
2019-11-27 | |
2016 |
Kliche A., Koop J., Ziegler C., Peterhoff D., Asbach B., Schütz A., Schmid V. and Wagner R Identification and characterization of trimer stabilized HIV envelope protein published pages: , ISSN: , DOI: |
2019-11-27 | |
2018 |
Ralf Wagner, Benedikt Asbach Dürfen wir noch auf eine HIV-Impfung hoffen? published pages: 24-27, ISSN: 1438-3276, DOI: 10.1007/s15006-018-0649-z |
MMW - Fortschritte der Medizin 160/S2 | 2019-11-27 |
2017 |
Ralf Wagner Effective HIV vaccine – Narrow path to broadly neutralizing antibodies (editorial) published pages: , ISSN: , DOI: |
2019-11-27 | |
2017 |
Max Medina-RamÃrez, Rogier W. Sanders, Quentin J. Sattentau Stabilized HIV-1 envelope glycoprotein trimers for vaccine use published pages: 1, ISSN: 1746-630X, DOI: 10.1097/COH.0000000000000363 |
Current Opinion in HIV and AIDS | 2019-11-27 |
2017 |
Ralf Wagner Effective HIV vaccine published pages: 191-194, ISSN: 1746-630X, DOI: 10.1097/coh.0000000000000371 |
Current Opinion in HIV and AIDS 12/3 | 2019-11-27 |
2017 |
David Peterhoff, Alexandra Hauser, Iris Ganser, Ralf Wagner Structure guided molecular engineering of stable C-clade Env trimer scaffolds for vaccine design published pages: , ISSN: , DOI: |
2019-11-27 | |
2017 |
David Peterhoff, Ralf Wagner Guiding the long way to broad HIV neutralization published pages: 257-264, ISSN: 1746-630X, DOI: 10.1097/coh.0000000000000356 |
Current Opinion in HIV and AIDS 12/3 | 2019-11-27 |
2016 |
Glögl M., Schmid V., Kliche A., Peterhoff D. and Wagner R Generation of HIV-1 new envelope immunogens with optimized antigenicity profiles published pages: , ISSN: , DOI: |
2019-11-27 | |
2017 |
Benedikt Asbach, Ralf Wagner Particle-based delivery of the HIV envelope protein published pages: 265-271, ISSN: 1746-630X, DOI: 10.1097/coh.0000000000000366 |
Current Opinion in HIV and AIDS 12/3 | 2019-11-27 |
2016 |
Carolina Beltrán Pavez , Amanda Fabra GarcÃa , Alberto Merino , Christian Brander, Josep M. Gatell, Felipe GarcÃa
EloÃsa Yuste and VÃctor Sánchez-Merino Induction of MPER responses by immunization with Virus-Like Particles (VLPs) carrying a BroadlyNeutralizing Antibody-selected HIV-1 Envelope published pages: , ISSN: , DOI: |
2019-11-27 | |
2017 |
Asbach B, Wagner R Particle-based delivery of the HIV envelope protein published pages: , ISSN: 1746-630X, DOI: |
Current Oppinion in HIV and AIDS | 2019-11-27 |
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