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assymcurv SIGNED

The influence of the cell membrane asymmetry and curvature on the functioning of membrane proteins and the transport of therapeutic compounds

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

assymcurv project word cloud

Explore the words cloud of the assymcurv project. It provides you a very rough idea of what is the project "assymcurv" about.

composition physical asymmetric host molecular inner splitting combination asymmetry exocytosis phosphoinositides infrared neutral orientation bodies phenomena coarse spectroscopy grained integral diffusion plasma cytoskeleton leaflets environment chemistry computer interdisciplinary proteins drugs complimentary dynamics curved synaptic functioning biochemistry membrane anionic experimental curvature molecules transport atomistic interactions small cisplatin compounds enveloped apoptotic influence raman wet influenced cellular biology derivatives essentially spontaneous budding cell simulations outer endo vesicles lipids therapeutic transmembrane fusion reveal manner membranes enhanced contain planar usually blebs real govern distinguish glycolipids practically quantum viruses

Project "assymcurv" data sheet

The following table provides information about the project.

Coordinator	INSTITUTE OF PHYSICS OF NATIONAL ACADEMY OF SCIENCE OF UKRAINE Organization address address: PROSPECT NAUKY 46 city: KYIV postcode: 3680 website: www.iop.kiev.ua contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ukraine [UA]
Total cost	202˙500 €
EC max contribution	202˙500 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2015
Funding Scheme	MSCA-RISE
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTE OF PHYSICS OF NATIONAL ACADEMY OF SCIENCE OF UKRAINE INSTITUTE OF PHYSICS OF NATIONAL ACADEMY OF SCIENCE OF UKRAINE Organization address address: PROSPECT NAUKY 46 city: KYIV postcode: 3680 website: www.iop.kiev.ua contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UA (KYIV)	coordinator	58˙500.00
2	UNIVERSITE DE FRANCHE-COMTE UNIVERSITE DE FRANCHE-COMTE Organization address address: 1 RUE CLAUDE GOUDIMEL city: BESANCON postcode: 25000 website: www.univ-fcomte.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (BESANCON)	participant	63˙000.00
3	LATVIJAS UNIVERSITATES CIETVIELU FIZIKAS INSTITUTS LATVIJAS UNIVERSITATES CIETVIELU FIZIKAS INSTITUTS Organization address address: KENGARAGA IELA 8 city: RIGA postcode: LV-1063 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LV (RIGA)	participant	45˙000.00
4	TARTU ULIKOOL TARTU ULIKOOL Organization address address: ULIKOOLI 18 city: TARTU postcode: 51005 website: www.ut.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	27˙000.00
5	MATERIALS RESEARCH CENTER MATERIALS RESEARCH CENTER Organization address address: YAROSLAVIV VAL/OLISYA GONCHARA STREET, 19/33-A city: KIEV postcode: 1034 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UA (KIEV)	participant	9˙000.00
6	THE UNIVERSITY OF TEXAS SYSTEM THE UNIVERSITY OF TEXAS SYSTEM Organization address address: COLORADO STREET 601 city: AUSTIN postcode: 78701 2982 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (AUSTIN)	partner	0.00
7	Universidade Federal de Juiz de Fora Universidade Federal de Juiz de Fora Organization address address: Rua Jose Lourenco Kelmer, s/n Camp Uni-Sao Pedro city: Juiz de Fora postcode: 36036-330 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (Juiz de Fora)	partner	0.00

Map

Project objective

Real cell membranes are essentially asymmetric and non-planar. Outer leaflets of the plasma membranes contain neutral lipids and glycolipids, while the inner leaflets host practically all anionic lipids and phosphoinositides. In addition to asymmetric composition the membranes are usually curved due to spontaneous curvature of the membrane lipids and an influence of membrane proteins and cytoskeleton. There are many cellular phenomena, which are influenced by the asymmetry and the membrane curvature such as formation of synaptic vesicles, blebs and apoptotic bodies, membrane fusion and splitting, budding of enveloped viruses, endo and exocytosis, etc. In this work we propose comprehensive interdisciplinary study of the influence of membrane asymmetry and curvature on the functioning of integral membrane proteins and the transmembrane transport of therapeutic compounds (such as cisplatin and its derivatives). The goal is to reveal major physical factors, which distinguish asymmetric and curved membrane environment and govern interactions, orientation and diffusion of the small molecules (drugs) and large integral proteins. The combination of experimental methods (“wet” biochemistry and molecular biology, enhanced infrared and Raman spectroscopy) and computer simulations (coarse-grained and atomistic molecular dynamics, quantum chemistry) would be used in the project in complimentary manner.

Deliverables

List of deliverables.
Comparison of experimental and simulation results	Other	2020-04-07 20:47:07
Curvature-dependent potentials of mean force for drug translocation through the membrane	Other	2020-04-07 20:47:07
Curvature-dependent conformational changes of the membrane proteins	Other	2020-04-07 20:47:07
Experimental markers of conformation changes in membrane-protein and membrane-drug complexes.	Other	2020-04-07 20:47:07
Progress report 2	Documents, reports	2020-04-07 20:47:07
Publishing and dissemination of results	Documents, reports	2020-04-07 20:47:07
Progress Report 1	Documents, reports	2020-04-07 20:47:06
Empirical force fields of the drugs	Other	2020-04-07 20:47:06
Coherent view of the project goals, methods and schedules	Documents, reports	2020-04-07 20:47:06
Mid-term meeting	Other	2020-04-07 20:47:06

Take a look to the deliverables list in detail: detailed list of assymcurv deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Arnaud Peramo, Simona Mura, Semen O. Yesylevskyy, Bruno Cardey, Dunja Sobot, Stephanie Denis, Christophe Ramseyer, Didier DesmaÃ«le, Patrick Couvreur Squalene versus cholesterol: Which is the best nanocarrier for the delivery to cells of the anticancer drug gemcitabine? published pages: 974-986, ISSN: 1631-0748, DOI: 10.1016/j.crci.2018.02.008	Comptes Rendus Chimie 21/10	2020-04-07
2019	Thibault Minervini, Bruno Cardey, Sarah Foley, Christophe Ramseyer, Mironel Enescu Fate of cisplatin and its main hydrolysed forms in the presence of thiolates: a comprehensive computational and experimental study published pages: 833-844, ISSN: 1756-5901, DOI: 10.1039/c8mt00371h	Metallomics 11/4	2020-04-07
2019	TimothÃ©e Rivel, Christophe Ramseyer, Semen Yesylevskyy The asymmetry of plasma membranes and their cholesterol content influence the uptake of cisplatin published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41903-w	Scientific Reports 9/1	2020-04-07
2019	Julie Mougin, Semen O. Yesylevskyy, Claudie Bourgaux, David Chapron, Jean-Philippe Michel, Franco Dosio, Barbara Stella, Christophe Ramseyer, Patrick Couvreur Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin published pages: 12870-12879, ISSN: 1936-0851, DOI: 10.1021/acsnano.9b05303	ACS Nano 13/11	2020-04-07
2019	Semen Yesylevskyy, TimothÃ©e Rivel, Christophe Ramseyer Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-53952-2	Scientific Reports 9/1	2020-04-07
2019	Kyrylo A. Pyrshev, Semen O. Yesylevskyy, Alexander P. Demchenko Double-exponential kinetics of binding and redistribution of the fluorescent dyes in cell membranes witness for the existence of lipid microdomains published pages: 1139-1144, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2018.12.054	Biochemical and Biophysical Research Communications 508/4	2020-04-07
2018	O. P. Gnatyuk, G. I. Dovbeshko, A. Yershov, S. O. Karakhim, O. Ilchenko, O. Yu. Posudievsky 2D-BN nanoparticles as a spectroscopic marker and drug delivery system with protection properties published pages: 30404-30411, ISSN: 2046-2069, DOI: 10.1039/c8ra05085f	RSC Advances 8/53	2020-04-07
2018	Yibin Lin, Mikhail Bogdanov, Shuo Lu, Ziqiang Guan, William Margolin, Jerrold Weiss, Lei Zheng The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A 2 attack published pages: 3386-3398, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.001231	Journal of Biological Chemistry 293/9	2020-04-07
2017	Lei Zheng, Yibin Lin, Shuo Lu, Jiazhe Zhang, Mikhail Bogdanov Biogenesis, transport and remodeling of lysophospholipids in Gram-negative bacteria published pages: 1404-1413, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2016.11.015	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862/11	2020-04-07
2016	Ludmila Davydova, Svetlana Bakholdina, Maria Barkina, Peter Velansky, Mikhail Bogdanov, Nina Sanina Effects of elevated growth temperature and heat shock on the lipid composition of the inner and outer membranes of Yersinia pseudotuberculosis published pages: 103-109, ISSN: 0300-9084, DOI: 10.1016/j.biochi.2016.02.004	Biochimie 123	2020-04-07
2017	Liina Kangur, Michael R. Jones, Arvi Freiberg Hydrogen bonds in the vicinity of the special pair of the bacterial reaction center probed by hydrostatic high-pressure absorption spectroscopy published pages: , ISSN: 0301-4622, DOI: 10.1016/j.bpc.2017.04.003	Biophysical Chemistry	2020-04-07
2017	KÃµu Timpmann, Liina Kangur, Ants LÃµhmus, Arvi Freiberg High-pressure modulation of the structure of the bacterial photochemical reaction center at physiological and cryogenic temperatures published pages: 144006, ISSN: 0953-4075, DOI: 10.1088/1361-6455/aa77e4	Journal of Physics B: Atomic, Molecular and Optical Physics 50/14	2020-04-07
2016	Manoop Chenchiliyan, KÃµu Timpmann, Erko Jalviste, Peter G. Adams, C. Neil Hunter, Arvi Freiberg Dimerization of core complexes as an efficient strategy for energy trapping in Rhodobacter sphaeroides published pages: 634-642, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2016.03.020	Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857/6	2020-04-07
2016	Arvi Freiberg, Manoop Chenchiliyan, Margus RÃ¤tsep, KÃµu Timpmann Spectral and kinetic effects accompanying the assembly of core complexes of Rhodobacter sphaeroides published pages: 1727-1733, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2016.08.001	Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857/11	2020-04-07
2017	TimothÃ©e Rivel, Semen O. Yesylevskyy, Christophe Ramseyer Structures of single, double and triple layers of lipids adsorbed on graphene: Insights from all-atom molecular dynamics simulations published pages: 358-369, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2017.03.072	Carbon 118	2020-04-07
2017	Dunja Sobot, Simona Mura, Semen O. Yesylevskyy, Laura Dalbin, Fanny Cayre, Guillaume Bort, Julie Mougin, Didier DesmaÃ«le, Sinda Lepetre-Mouelhi, GrÃ©gory Pieters, Bohdan Andreiuk, Andrey S. Klymchenko, Jean-Louis Paul, Christophe Ramseyer, Patrick Couvreur Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery published pages: 15678, ISSN: 2041-1723, DOI: 10.1038/ncomms15678	Nature Communications 8	2020-04-07

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