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MICROBRADAM SIGNED

Advanced MR methods for characterization of microstructural brain damage

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MICROBRADAM project word cloud

Explore the words cloud of the MICROBRADAM project. It provides you a very rough idea of what is the project "MICROBRADAM" about.

tested extremely magnetic class biophysical contrast tissue usefulness notably neuroscientists correct heavily promise offers flexibility assessing sensitivity spins mri multiparametric routine microstructural expanding microscopic mr clinical proper neurodegenerative world brain lack pathologies scientific damage technological truly networking site ultimately limited validated exchanging nmr data poor imaging commercial room extreme merged neurosciences sites newly valuable nuclear manipulation mechanisms complimentary exquisite country nonetheless improvements techniques academic affirmed pulse expanded diseases sequences suffer pathology establishing specificity community made course biological resonance

Project "MICROBRADAM" data sheet

The following table provides information about the project.

Coordinator	MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI Organization address address: VIA PANISPERNA 89/A city: ROMA postcode: 184 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://microbradam.marbilab.eu
Total cost	540˙000 €
EC max contribution	540˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2015
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-11-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI Organization address address: VIA PANISPERNA 89/A city: ROMA postcode: 184 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	coordinator	162˙000.00
2	FAKULTNI NEMOCNICE U SV. ANNY V BRNE FAKULTNI NEMOCNICE U SV. ANNY V BRNE Organization address address: Pekarska 53 city: Brno postcode: 656 91 website: www.fnusa.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (Brno)	participant	90˙000.00
3	ITA-SUOMEN YLIOPISTO ITA-SUOMEN YLIOPISTO Organization address address: YLIOPISTONRANTA 1 E city: KUOPIO postcode: 70211 website: www.uef.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (KUOPIO)	participant	90˙000.00
4	Masarykova univerzita Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	participant	90˙000.00
5	CHARLES RIVER DISCOVERY RESEARCH SERVICES FINLAND OY CHARLES RIVER DISCOVERY RESEARCH SERVICES FINLAND OY Organization address address: MICROKATU 1 city: KUOPIO postcode: 70210 website: www.cerebricon.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (KUOPIO)	participant	54˙000.00
6	UNIVERSITA DEGLI STUDI DI SALERNO UNIVERSITA DEGLI STUDI DI SALERNO Organization address address: VIA GIOVANNI PAOLO II 132 city: FISCIANO SA postcode: 84084 website: www.unisa.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FISCIANO SA)	participant	54˙000.00
7	REGENTS OF UNIVERSITY OF MINNESOTA REGENTS OF UNIVERSITY OF MINNESOTA Organization address address: OAK STREET SE 200 MCNAMARA ALUMNI CENTER 450 city: MINNEAPOLIS MN postcode: 55455 2070 website: www.umn.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (MINNEAPOLIS MN)	partner	0.00

Map

Project objective

NMR (Nuclear Magnetic Resonance)-based approaches have affirmed as extremely valuable for applications in neurosciences. Nonetheless, the exquisite flexibility of tissue contrast in magnetic resonance imaging (MRI) that can be obtained by proper manipulation of nuclear spins still offers room for technological improvements which can be quickly expanded to clinical routine. In particular, there is extreme need of imaging methods that allow a correct assessment of microstructural damage in many brain diseases, including – but not limited to – neurodegenerative diseases. Indeed, current MRI techniques suffer from poor specificity and ultimately lack the ability to identify the microscopic biophysical and biological mechanisms related to the specific features of the pathology. This project aims at expanding the set of MR based techniques available to neuroscientists to characterize microstructural damage, assessing the usefulness of these approaches in some specific pathologies where they offer more promise. Notably, this project aims also at establishing the increased specificity and sensitivity of newly developed and current techniques when merged in a truly multiparametric analysis approach. This project is heavily based on networking activities for exchanging the complimentary knowledge available at the different world-class academic and commercial EU and third country sites. The novel MRI pulse sequences and data analyses approaches tested and validated during the course of the project will be available at each site of the consortium, and will be made available to the scientific community as well.

Deliverables

List of deliverables.
Press conferences	Other	2020-02-07 15:38:57
Scientific workshops	Other	2020-02-07 15:39:02
â€œDoors openâ€	Other	2019-06-06 16:13:50
Human dataset complete, final report	Other	2019-06-06 16:13:46
Scientific publications on MRI development/application on humans	Documents, reports	2019-05-09 09:30:39
Web site released	Websites, patent fillings, videos etc.	2019-05-16 12:44:27
Scientific publications on MRI development/application on animals	Documents, reports	2019-05-16 12:44:28

Take a look to the deliverables list in detail: detailed list of MICROBRADAM deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Pavel Filip, Pavla LinhartovÃ¡, PavlÃna HlavatÃ¡, Rastislav Å umec, Marek BalÃ¡Å¾, Martin BareÅ¡, TomÃ¡Å¡ KaÅ¡pÃ¡rek Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson\'s Disease published pages: , ISSN: 1662-5161, DOI: 10.3389/fnhum.2018.00462	Frontiers in Human Neuroscience 12	2020-02-27
2020	PavlÃna HlavatÃ¡, Pavla LinhartovÃ¡, Rastislav Å umec, Pavel Filip, Miroslav SvÄ›tlÃ¡k, Marek BalÃ¡Å¾, TomÃ¡Å¡ KaÅ¡pÃ¡rek, Martin BareÅ¡ Behavioral and Neuroanatomical Account of Impulsivity in Parkinson\'s Disease published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2019.01338	Frontiers in Neurology 10	2020-02-27
2020	Michela Fratini, Ali Abdollahzadeh, Mauro DiNuzzo, Raimo A. Salo, Laura Maugeri, Alessia Cedola, Federico Giove, Olli GrÃ¶hn, Jussi Tohka, Alejandra Sierra Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective published pages: 72, ISSN: 1662-453X, DOI: 10.3389/fnins.2020.00072	Frontiers in Neuroscience 14	2020-02-13
2018	Timo Liimatainen, Hanne Laakso, Djaudat Idiyatullin, Silvia Mangia, Shalom Michaeli Capturing exchange using periodic radiofrequency irradiation published pages: 79-84, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2018.09.001	Journal of Magnetic Resonance 296	2019-11-11
2018	E. Stefanutti, A. Sierra, P. Miocchi, L. Massimi, F. Brun, L. Maugeri, I. Bukreeva, A. Nurmi, G. Begani Provinciali, G. Tromba, O. GrÃ¶hn, F. Giove, A. Cedola, M. Fratini Assessment of the effects of different sample perfusion procedures on phase-contrast tomographic images of mouse spinal cord published pages: C03027-C03027, ISSN: 1748-0221, DOI: 10.1088/1748-0221/13/03/C03027	Journal of Instrumentation 13/03	2019-05-09
2018	Silvia Tommasin, Daniele Mascali, Marta Moraschi, Tommaso Gili, Ibrahim Eid Hassan, Michela Fratini, Mauro DiNuzzo, Richard G. Wise, Silvia Mangia, Emiliano Macaluso, Federico Giove Scale-invariant rearrangement of resting state networks in the human brain under sustained stimulation published pages: 570-581, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.06.006	NeuroImage 179	2019-05-09
2018	Silvia Mangia, Alena Svatkova, Daniele Mascali, Mikko J. Nissi, Philip C. Burton, Petr Bednarik, Edward J. Auerbach, Federico Giove, Lynn E. Eberly, Michael J. Howell, Igor Nestrasil, Paul J. Tuite, Shalom Michaeli Corrigendum: Multi-modal Brain MRI in Subjects with PD and iRBD published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00446	Frontiers in Neuroscience 12	2019-05-09
2017	Lauri J. Lehto, Djaudat Idiyatullin, Jinjin Zhang, Lynn Utecht, Gregor Adriany, Michael Garwood, Olli GrÃ¶hn, Shalom Michaeli, Silvia Mangia MB-SWIFT functional MRI during deep brain stimulation in rats published pages: 443-448, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.08.012	NeuroImage 159	2019-06-17
2017	Silvia Mangia, Alena Svatkova, Daniele Mascali, Mikko J. Nissi, Philip C. Burton, Petr Bednarik, Edward J. Auerbach, Federico Giove, Lynn E. Eberly, Michael J. Howell, Igor Nestrasil, Paul J. Tuite, Shalom Michaeli Multi-modal Brain MRI in Subjects with PD and iRBD published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00709	Frontiers in Neuroscience 11	2019-06-17
2018	Daniele Mascali, Mauro DiNuzzo, Laura Serra, Silvia Mangia, Bruno Maraviglia, Marco Bozzali, Federico Giove Disruption of Semantic Network in Mild Alzheimerâ€™s Disease Revealed by Resting-State fMRI published pages: 38-48, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.11.030	Neuroscience 371	2019-06-17
2017	Lauri J Lehto, Julia P Slopsema, Matthew D Johnson, Artem Shatillo, Benjamin A Teplitzky, Lynn Utecht, Gregor Adriany, Silvia Mangia, Alejandra Sierra, Walter C Low, Olli GrÃ¶hn, Shalom Michaeli Orientation selective deep brain stimulation published pages: 16016, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aa5238	Journal of Neural Engineering 14/1	2019-06-17
2017	Silvia Tommasin, Daniele Mascali, Tommaso Gili, Ibrahim Eid Assan, Marta Moraschi, Michela Fratini, Richard G. Wise, Emiliano Macaluso, Silvia Mangia, Federico Giove Task-Related Modulations of BOLD Low-Frequency Fluctuations within the Default Mode Network published pages: , ISSN: 2296-424X, DOI: 10.3389/fphy.2017.00031	Frontiers in Physics 5	2019-06-17
2017	Mauro DiNuzzo, Daniele Mascali, Marta Moraschi, Giorgia Bussu, Bruno Maraviglia, Silvia Mangia, Federico Giove Temporal Information Entropy of the Blood-Oxygenation Level-Dependent Signals Increases in the Activated Human Primary Visual Cortex published pages: , ISSN: 2296-424X, DOI: 10.3389/fphy.2017.00007	Frontiers in Physics 5	2019-06-17
2018	Ivan Rektor, Alena SvÃ¡tkovÃ¡, Lubomir VojtÃÅ¡ek, Iva ZikmundovÃ¡, JirÃ VanÃÄek, AndrÃ¡s KirÃ¡ly, Nikoletta SzabÃ³ White matter alterations in Parkinsonâ€™s disease with normal cognition precede grey matter atrophy published pages: e0187939, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0187939	PLOS ONE 13/1	2019-06-17
2017	Lauri J. Lehto, Aloma A. Albors, Alejandra Sierra, Laura Tolppanen, Lynn E. Eberly, Silvia Mangia, Antti Nurmi, Shalom Michaeli, Olli GrÃ¶hn Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00433	Frontiers in Neuroscience 11	2019-06-17

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