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NanoIntra SIGNED

Multitasking Nanoparticles for Intracellular Bioimaging and Biosensing

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 NanoIntra project word cloud

Explore the words cloud of the NanoIntra project. It provides you a very rough idea of what is the project "NanoIntra" about.

reveal    matrix    play    mystery    spatial    position    constitutes    diseases    structures    chemistry    purposefully    nanobiophotonics    medical    nanomaterials    luminescent    stable    labeling    manipulate    cell    cells    multitasking    silica    inside    intracellular    objects    multidisciplinary    theranostics    subcellular    physics    tweezers    quantum    bright    nanocrystals    region    plasmonic    diagnostic    strategies    biology    nanomedicine    combined    encapsulated    dots    particle    nanoparticles    cancer    localized    architecture    techniques    markers    training    first    ultrasensitive    nanoprobes    biosensing    characterization    protective    scattering    lab    biosensors    surface    optical    economic    designed    temporal    nanointra    societal    interface    functional    enhanced    thanks    toward    tremendous    functionalization    spread    sers    raman    biotechnology    promises    treatment    hold    materials    full    synthesis    photothermally    imaging    entitled    insights    besides    live    nano    proper    tools    outcomes   

Project "NanoIntra" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITEIT GENT 

Organization address
address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000
website: http://www.ugent.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Belgium [BE]
 Project website https://www.ugent.be/en/research/research-ugent/trackrecord/trackrecord-h2020/msca-h2020/msca-nanointra.htm
 Total cost 258˙530 €
 EC max contribution 258˙530 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT BE (GENT) coordinator 258˙530.00
2    CORNELL UNIVERSITY US (ITHACA NY) partner 0.00

Map

 Project objective

The development of specifically designed nanomaterials for advanced medical applications such as theranostics has become a major technical challenge with great potential societal and economic outcomes. Nanomedicine and related techniques hold great promises for improved diagnostic and treatment of widely spread diseases such as cancer. This project, entitled NanoIntra, aims at developing novel multitasking nanoparticles as advanced tools for highly localized and ultrasensitive intracellular imaging and biosensing. These nanoprobes should provide new insights in the spatial and temporal processes at play in live cells and therefore reveal part of their mystery. Such functional objects are achieved through the design of a complex architecture which involves quantum dots as bright and stable luminescent markers encapsulated in a protective silica matrix. These nanoparticles are combined with plasmonic nanocrystals, which offer new strategies for their photothermally induced intracellular delivery. The targeting and imaging of specific subcellular structures is then achieved thanks to proper surface functionalization of the nanoparticles. In addition, the plasmonic nanocrystals also allow these nanoparticles to be used as Surface Enhanced Raman Scattering (SERS) biosensors. Finally, for a higher control on the use of such nano-biosensors, optical tweezers are used to purposefully manipulate and position the nanoparticles inside the cells at the region of interest. Besides their application in cell labeling and biosensing, these functional nanoparticles have tremendous potential applications in the fields of theranostics, nanomedicine and nanobiophotonics, and NanoIntra constitutes a first step toward the development of a full lab-on-a-particle. Thus, through the synthesis and characterization of novel materials and their application to biotechnology, NanoIntra is a multidisciplinary research and training project at the interface between physics, chemistry and biology.

 Publications

year authors and title journal last update
List of publications.
2018 Kai Ma, Katherine A. Spoth, Ying Cong, Duhan Zhang, Tangi Aubert, Melik Z. Turker, Lena F. Kourkoutis, Eduardo Mendes, Ulrich Wiesner
Early Formation Pathways of Surfactant Micelle Directed Ultrasmall Silica Ring and Cage Structures
published pages: 17343-17348, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08802 		Journal of the American Chemical Society 140/50 2020-02-25
2018 Teresa Kao, Ferdinand Kohle, Kai Ma, Tangi Aubert, Alexander Andrievsky, Ulrich Wiesner
Fluorescent Silica Nanoparticles with Well-Separated Intensity Distributions from Batch Reactions
published pages: 1305-1310, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b04978 		Nano Letters 18/2 2020-02-25
2018 Suzanne Bisschop, Pieter Geiregat, Tangi Aubert, Zeger Hens
The Impact of Core/Shell Sizes on the Optical Gain Characteristics of CdSe/CdS Quantum Dots
published pages: 9011-9021, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b02493 		ACS Nano 12/9 2020-02-25
2018 Kai Ma, Yunye Gong, Tangi Aubert, Melik Z. Turker, Teresa Kao, Peter C. Doerschuk, Ulrich Wiesner
Self-assembly of highly symmetrical, ultrasmall inorganic cages directed by surfactant micelles
published pages: 577-580, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0221-0 		Nature 558/7711 2020-02-25

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The information about "NANOINTRA" are provided by the European Opendata Portal: CORDIS opendata.

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