Explore the words cloud of the MinBioTag project. It provides you a very rough idea of what is the project "MinBioTag" about.
The following table provides information about the project.
Coordinator |
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://gbernardeslab.com/ |
Total cost | 183˙454 € |
EC max contribution | 183˙454 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2015 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2016 |
Duration (year-month-day) | from 2016-04-01 to 2018-03-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE | UK (CAMBRIDGE) | coordinator | 183˙454.00 |
Insight into dynamic processes such as uptake and intracellular trafficking and signalling of small molecules and proteins in cells is key in basic biology and drug development. The use of bioorthogonal chemical reactions for labelling and probing specific biomolecules is an exciting option but a very challenging task as these transformations should proceed very rapidly in physiological conditions with complete chemoselectivity. So, in this application we propose to achieve site-selective protein labelling by the introduction of a non-canonical Cys-cyclobutene aminoacid and a very fast alkene chemoselective ligation reaction. The small size of the proposed alkene-tagged aminoacid should not interfere with the protein structure, function, activity or localisation in contrast with other fluorescent tags such as the use of fusion proteins as GFP. This project aims at 1) developing a new photo triggered [22] cycloaddition bioorthogonal ligation between two alkene containing partners and to apply the already established IEDDA reaction between tetrazines and dienophiles. While the use of light as a trigger offers the possibility for an improved spatial and temporal resolution, the use of tetrazine fluorogenic probes allows for ‘turn-on’ fluorescence on their rapid reaction with dienophiles 2) use these optimized reaction to study apoptosis in cells and tissues by introducing the proposed Cys-cyclobutene non-canonical amino acid into C2A Domain of Synaptotagmin-I followed by the ligation reaction ex vivo and in vivo
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Annabel Kitowski, Ester Jiménez-Moreno, MÃriam Salvadó, Jordi Mestre, Sergio Castillón, Gonzalo Jiménez-Osés, Omar Boutureira, Gonçalo J. L. Bernardes Oxidative Activation of C–S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides published pages: 5490-5493, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b02886 |
Organic Letters 19/19 | 2019-06-13 |
2017 |
Ester Jiménez-Moreno, Zijian Guo, Bruno L. Oliveira, Inês S. Albuquerque, Annabel Kitowski, Ana Guerreiro, Omar Boutureira, Tiago Rodrigues, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells published pages: 243-247, ISSN: 1433-7851, DOI: 10.1002/anie.201609607 |
Angewandte Chemie International Edition 56/1 | 2019-06-13 |
2018 |
Bernadette Lee, Shuang Sun, Ester Jiménez-Moreno, André A. Neves, Gonçalo J.L. Bernardes Site-selective installation of an electrophilic handle on proteins for bioconjugation published pages: , ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.02.028 |
Bioorganic & Medicinal Chemistry | 2019-06-13 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MINBIOTAG" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MINBIOTAG" are provided by the European Opendata Portal: CORDIS opendata.