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BIASTRESS SIGNED

Neural mechanisms of cognitive bias and its role in the triggering of the stress response in zebrafish

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BIASTRESS project word cloud

Explore the words cloud of the BIASTRESS project. It provides you a very rough idea of what is the project "BIASTRESS" about.

susceptibility demographic mechanisms critical meaningfully manipulations perspective sciences srmd neural treatment mental drug neuroendocrine societal scientifically wellbeing bias health scientific diagnosis disorders phenotypes individuals elucidate circuits behavioural human combining variation profiles chronic diseases multidisciplinary mediating diverge assessing personality hence community pessimistic helpful detrimental depression inter antidepressant physiological humans zebrafish anxiety tools stressors goals mitigate danio cognitive stress biastress appraisal optimistic resilience sound genetically biological model individual attributes extremely bases leveraged ways rerio linked clinical traits activation antidepressants

Project "BIASTRESS" data sheet

The following table provides information about the project.

Coordinator	FUNDACAO CALOUSTE GULBENKIAN Organization address address: AVENIDA BERNA 45 city: LISBOA postcode: 1000 website: www.igc.gulbenkian.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	160˙635 €
EC max contribution	160˙635 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2018-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACAO CALOUSTE GULBENKIAN FUNDACAO CALOUSTE GULBENKIAN Organization address address: AVENIDA BERNA 45 city: LISBOA postcode: 1000 website: www.igc.gulbenkian.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	160˙635.00

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Project objective

Assessing the stress resilience of optimistic and pessimistic phenotypes is crucial for the study of stress-related mental disorders (SRMD) in humans (e.g., anxiety and depression). However, only by understanding the neural mechanisms of cognitive bias and its role in the triggering of the stress response can these personality traits be meaningfully linked to susceptibility to SRMD. In this way, BIASTRESS will characterize the behavioural and neuroendocrine profiles of “optimistic” and “pessimistic” individuals and will assess if cognitive bias (e.g. pessimistic bias) is mediating the inter-individual variation in the susceptibility to the detrimental effects of stress. Furthermore, genetically manipulations of the neural circuits involved in the cognitive appraisal of stressors will be conducted in order to evaluate its effects on the activation of the stress response. BIASTRESS aims to elucidate this important matter using zebrafish (Danio rerio) as a model. The unique attributes of the zebrafish biological model are being increasingly leveraged by the scientific community to provide critical scientific bases for the development of new clinical tools for the diagnosis and treatment of human diseases. Hence, the multidisciplinary and unique perspective that will be adopted by this project, combining behavioural, neural and physiological sciences, has the potential to provide useful and scientifically-sound information to explain susceptibility to SRMD in humans, which will be extremely useful for developing ways to mitigate the effects of chronic stress. Moreover, this project will also be helpful in the field of antidepressant drug research, since pessimistic and optimistic individuals may diverge in their response to antidepressants. In this way, the goals of BIASTRESS directly address the societal challenge priority of health, demographic change and wellbeing established by the H2020 Work Programme.

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The information about "BIASTRESS" are provided by the European Opendata Portal: CORDIS opendata.