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SmartCubes SIGNED

An innovative class of nanoparticles (“SmartCubes”) for the targeted delivery of protein therapeutics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SmartCubes project word cloud

Explore the words cloud of the SmartCubes project. It provides you a very rough idea of what is the project "SmartCubes" about.

cubic construction reconstitute bilayer alternative fundamental hosted create protein displaying sciences area revolutionise loading small platform delivering too modifying contain outer networks treatments selectivity vehicle instability adenocarcinoma uniquely life degradation transform attempts limited membrane rapid complexity antibody tune colon water smartcubes surpass group prevented am combat therapeutics sizes honeycomb class selective selectively cancer 2014 disease house innovative sufficiently nanoparticles stable enter surface cells unprecedented sponge lipid proteins levels therapeutic structure conventional channels

Project "SmartCubes" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.stevensgroup.org/index.php/people
Total cost	185˙857 €
EC max contribution	185˙857 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-06-01 to 2019-03-20

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	185˙857.00

Map

Project objective

'SmartCubes' are an innovative class of nanoparticles for the targeted delivery of protein therapeutics. The objective is to deliver high levels of membrane proteins to cancer cells to combat disease. I will achieve this by creating novel 'sponge-like' targeted nanoparticles (SmartCubes) to selectively deliver unprecedented levels of a cancer therapeutic protein to colon adenocarcinoma cells.

‘SmartCubes’ are based on a cubic membrane structure. They contain a highly stable lipid bilayer displaying a 'honeycomb-like' construction. This structure has prevented previous applications as the water channels were too small for large proteins to enter and reconstitute into the membrane. I am uniquely able to tune the sizes of the water channels within the 'SmartCubes' to create water networks sufficiently large to house a whole new class of proteins. I will achieve this new class of nanoparticles by creating 'SmartCubes', modifying the outer surface of the 'SmartCubes' with a selective antibody, loading the cubic membrane with a cancer therapeutic protein and delivering them to cancer cells.

Protein therapeutics are an exciting alternative to conventional cancer treatments due to reduced side effects and their high target selectivity. I can surpass previous attempts which were limited by rapid protein degradation and the instability of the delivery vehicle. As protein therapeutics increase in complexity, there is a need for stable, high surface area, membrane based delivery systems. This project, hosted in the 2014 European life sciences group of the year, will transform my fundamental research into a platform technology that will revolutionise the field of protein therapeutics.

Publications

List of publications.
year	authors and title	journal	last update
2019	Hanna M. G. Barriga, Margaret N. Holme, Molly M. Stevens Cubosomes: The Next Generation of Smart Lipid Nanoparticles? published pages: 2958-2978, ISSN: 1433-7851, DOI: 10.1002/anie.201804067	Angewandte Chemie International Edition 58/10	2019-09-04
2018	Margaret N. Holme, M. Harunur Rashid, Michael R. Thomas, Hanna M. G. Barriga, Karlaâˆ’Luise Herpoldt, Richard K. Heenan, CÃ©cile A. Dreiss, JosÃ© Leobardo BaÃ±uelos, Hai-nan Xie, Irene Yarovsky, Molly M. Stevens Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement published pages: 1023-1030, ISSN: 2374-7943, DOI: 10.1021/acscentsci.8b00286	ACS Central Science 4/8	2019-09-04
2018	Margaret N. Holme, Subinoy Rana, Hanna M. G. Barriga, Ulrike Kauscher, Nicholas J. Brooks, Molly M. Stevens A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors published pages: 8197-8207, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b03308	ACS Nano 12/8	2019-09-04
2017	Joanna L. Richens, Arwen I. I. Tyler, Hanna M. G. Barriga, Jonathan P. Bramble, Robert V. Law, Nicholas J. Brooks, John M. Seddon, Oscar Ces, Paul Oâ€™Shea Spontaneous charged lipid transfer between lipid vesicles published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12611-0	Scientific Reports 7/1	2019-09-04

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The information about "SMARTCUBES" are provided by the European Opendata Portal: CORDIS opendata.