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CFQMLD

A Computational Framework For Quantitative Modeling of Leaf Development in Arabidopsis and Cardamine

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CFQMLD project word cloud

Explore the words cloud of the CFQMLD project. It provides you a very rough idea of what is the project "CFQMLD" about.

experimental    shape    action    leaf    linking    individual    model    training    forms    intersection    elucidate    ideal    form    sculpting    falling    genetic    computer    shapes    door    final    remarkable    hirsuta    molecular    vehicle    gene    species    organization    macroscopic    close    division    context    expertise    progress    relative    promise    deeply    developmental    elusive    complexity    genes    leaves    thaliana    relation    modeling    framework    tissue    opens    models    interrogation    efforts    understanding    leafed    plant    displaying    cell    organisms    quantitative    eukaryotic    interactions    fundamental    strengths    interdisciplinary    insights    tsiantis    permit    interface    exploits    determinants    proposes    compound    chain    emerges    confounded    regulation    biology    underlying    lab    combined    expression    manner    consequently    striking    living    informed    mechanistic    diversity    systematic    computational    science    self   

Project "CFQMLD" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.mpipz.mpg.de/tsiantis
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

Understanding how form emerges in living organisms is a fundamental challenge for biology. Progress, however, has been confounded by the complex chain of interactions underlying the organization of macroscopic forms from molecular processes. Consequently, insights into the manner in which individual genes contribute to the development of form have been elusive; even in well-studied model organisms. In this context, leaves provide a striking example of the self-organization of form – displaying remarkable diversity within and between species. Now, exploiting the close relation between simple leafed A. thaliana and compound leafed C. hirsuta, the Tsiantis lab has identified the key genetic factors underlying their distinct leaf shapes. This opens the door to a detailed understanding of the developmental factors sculpting leaf form.

Due to the complexity of leaf development, however, a mechanistic understanding of these factors requires computational models, informed by detailed quantitative measurements of growth and gene expression. Such models permit the systematic interrogation of the interactions linking genetic regulation, cell division and tissue growth to final form. This action proposes to develop such a computational framework. When combined with experimental efforts, these models promise to help elucidate the regulation of leaf form and provide essential insights into shape regulation in eukaryotic systems. The proposed research is deeply interdisciplinary, working at the interface of computer science and developmental biology. Falling directly at the intersection of the Tsiantis lab's expertise in studying the molecular determinants of leaf form and my expertise in computational modeling of plant development, it fully exploits our relative strengths. Thus providing an ideal vehicle to facilitate essential training while addressing a fundamental research problem.

 Publications

year authors and title journal last update
List of publications.
2018 Francesco Vuolo, Daniel Kierzkowski, Adam Runions, Mohsen Hajheidari, Remco A. Mentink, Mainak Das Gupta, Zhongjuan Zhang, Daniela Vlad, Yi Wang, Ales Pecinka, Xiangchao Gan, Angela Hay, Peter Huijser, Miltos Tsiantis
LMI1 homeodomain protein regulates organ proportions by spatial modulation of endoreduplication
published pages: 1361-1366, ISSN: 0890-9369, DOI: 10.1101/gad.318212.118
Genes & Development 32/21-22 2019-07-26
2019 Aleksandra Sapala, Adam Runions, Richard S Smith
Mechanics, geometry and genetics of epidermal cell shape regulation: different pieces of the same puzzle
published pages: 1-8, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2018.07.017
Current Opinion in Plant Biology 47 2019-07-26
2018 Aleksandra Sapala, Adam Runions, Anne-Lise Routier-Kierzkowska, Mainak Das Gupta, Lilan Hong, Hugo Hofhuis, Stéphane Verger, Gabriella Mosca, Chun-Biu Li, Angela Hay, Olivier Hamant, Adrienne HK Roeder, Miltos Tsiantis, Przemyslaw Prusinkiewicz, Richard S Smith
Why plants make puzzle cells, and how their shape emerges
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.32794
eLife 7 2019-07-26
2017 Adam Runions, Miltos Tsiantis
The shape of things to come: From typology to predictive models for leaf diversity
published pages: 1437-1441, ISSN: 0002-9122, DOI: 10.3732/ajb.1700251
American Journal of Botany 104/10 2019-07-26

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The information about "CFQMLD" are provided by the European Opendata Portal: CORDIS opendata.

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