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HONEYDIAB-8

Characterization of islet-specific CD8 T cells in the honeymoon of type 1 diabetes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HONEYDIAB-8 project word cloud

Explore the words cloud of the HONEYDIAB-8 project. It provides you a very rough idea of what is the project "HONEYDIAB-8" about.

exposure    exogenous    postulating    effector    differentiation    patients    oversee    interesting    quality    disease    immunotherapies    enzyme    few    human    biomarkers    vivo    beta    optimized    metabolic    assays    longitudinal    cell    insulin    presumably    collaborations    first    usually    gene    immunoassays    cytometry    cross    opportunity    characterization    career    cells    autoimmunity    antigen    flow    technological    identification    follow    immunology    expression    pancreatic    plan    death    involve    unusual    effectors    establishment    highlighting    reflect    honeymoon    immunological    producing    attack    islets    unknown    immunobiology    period    sectional    industry    collected    chronic    suitable    antigens    novelty    metabolism    remission    poorly    fundamental    regeneration    diabetes    analysed    perform    t1d    langerhans    tolerance    possibilities    re    self    functional    attempt    pursuing    islet    cd8    autoimmune    memory    relate    decreased    though    type    final    modulation    originality   

Project "HONEYDIAB-8" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.kcl.ac.uk/lsm/research/divisions/diiid/departments/immunobiology/research/peakman/currentresearch
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-15   to  2019-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Type 1 Diabetes (T1D) is a metabolic disease that results from the autoimmune attack against insulin-producing β-cells in the pancreatic islets of Langerhans. T1D usually comprises a phase called ‘honeymoon’, an interesting though poorly studied period of the disease where exogenous insulin requirements are decreased, postulating a possible attempt of β-cell regeneration and a remission of the autoimmunity. The proposed research aims to identify and characterize islet-specific CD8 T cells, the final effectors of β-cell death, in the honeymoon of T1D. We plan to perform a cross-sectional and longitudinal study with T1D patients where the immunological and metabolic characterization will be collected during the first year of the disease, and analysed by flow cytometry, enzyme immunoassays, gene expression and functional assays.

The project addresses the characterization of the following unknown immunological features, pursuing a novel concept in T1D field: the role of antigen-specific CD8 T cells in the modulation of autoimmune response in the honeymoon phase. There will be technological and fundamental Immunobiology advances provided by the opportunity to analyse effector cells in these unusual effector memory differentiation states, which presumably reflect chronic exposure to self-antigens. Finally, the highlighting of suitable T-cell related biomarkers for the honeymoon could help in the early identification of the patients with best tolerance re-establishment potential, as well as providing an optimized follow up of future immunotherapies. There are very few studies of key immunology processes as they relate to human metabolism in vivo, and the applicant will learn how to oversee these. The high-quality and originality of the proposed research will open up the best career possibilities for the applicant through and its novelty could also involve industry collaborations.

 Publications

year authors and title journal last update
List of publications.
2018 Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
published pages: 3460-3474, ISSN: 0021-9738, DOI: 10.1172/jci120555
Journal of Clinical Investigation 128/8 2020-02-07

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