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HONEYDIAB-8

Characterization of islet-specific CD8 T cells in the honeymoon of type 1 diabetes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HONEYDIAB-8 project word cloud

Explore the words cloud of the HONEYDIAB-8 project. It provides you a very rough idea of what is the project "HONEYDIAB-8" about.

poorly    attempt    characterization    chronic    human    assays    islet    islets    technological    fundamental    patients    possibilities    immunology    unusual    remission    vivo    tolerance    enzyme    t1d    cell    collected    plan    exogenous    career    perform    presumably    industry    immunotherapies    suitable    cd8    gene    sectional    collaborations    quality    autoimmunity    period    antigens    attack    honeymoon    type    establishment    optimized    modulation    producing    self    though    cross    diabetes    expression    postulating    highlighting    antigen    effector    final    differentiation    reflect    immunobiology    cytometry    biomarkers    insulin    first    exposure    langerhans    follow    novelty    identification    analysed    effectors    metabolism    autoimmune    interesting    regeneration    flow    longitudinal    originality    opportunity    cells    decreased    involve    relate    functional    disease    few    memory    immunoassays    pursuing    beta    immunological    pancreatic    re    oversee    unknown    metabolic    death    usually   

Project "HONEYDIAB-8" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
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name: n.a.
surname: n.a.
function: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.kcl.ac.uk/lsm/research/divisions/diiid/departments/immunobiology/research/peakman/currentresearch
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-15   to  2019-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Type 1 Diabetes (T1D) is a metabolic disease that results from the autoimmune attack against insulin-producing β-cells in the pancreatic islets of Langerhans. T1D usually comprises a phase called ‘honeymoon’, an interesting though poorly studied period of the disease where exogenous insulin requirements are decreased, postulating a possible attempt of β-cell regeneration and a remission of the autoimmunity. The proposed research aims to identify and characterize islet-specific CD8 T cells, the final effectors of β-cell death, in the honeymoon of T1D. We plan to perform a cross-sectional and longitudinal study with T1D patients where the immunological and metabolic characterization will be collected during the first year of the disease, and analysed by flow cytometry, enzyme immunoassays, gene expression and functional assays.

The project addresses the characterization of the following unknown immunological features, pursuing a novel concept in T1D field: the role of antigen-specific CD8 T cells in the modulation of autoimmune response in the honeymoon phase. There will be technological and fundamental Immunobiology advances provided by the opportunity to analyse effector cells in these unusual effector memory differentiation states, which presumably reflect chronic exposure to self-antigens. Finally, the highlighting of suitable T-cell related biomarkers for the honeymoon could help in the early identification of the patients with best tolerance re-establishment potential, as well as providing an optimized follow up of future immunotherapies. There are very few studies of key immunology processes as they relate to human metabolism in vivo, and the applicant will learn how to oversee these. The high-quality and originality of the proposed research will open up the best career possibilities for the applicant through and its novelty could also involve industry collaborations.

 Publications

year authors and title journal last update
List of publications.
2018 Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
published pages: 3460-3474, ISSN: 0021-9738, DOI: 10.1172/jci120555
Journal of Clinical Investigation 128/8 2020-02-07

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