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CaLiAT

A novel pathway for generation of building blocks for antibiotic biosynthesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 CaLiAT project word cloud

Explore the words cloud of the CaLiAT project. It provides you a very rough idea of what is the project "CaLiAT" about.

blocks    substrates    actinomycete    diversity    sequence    enzymes    chemical    biochemical    secondly    newly    genome    published    vitro    extender    carboxylases    biology    sustainable    time    fed    biotin    spread    sequencing    animals    targetted    threat    strains    routes    analogues    polyketide    polyketides    microorganisms    humans    confirm    strategies    parts    alteration    leads    revival    databases    additional    acyltransferase    accept    rational    search    units    experiencing    expand    offers    building    gene    training    unusual    ligases    natural    examples    potentially    biosynthetic    resistance    candidate    supplying    bacteria    precursors    insights    cognate    pool    first    ligase    leadership    antibiotic    divides    specificity    equip    sought    acids    dependent    biosynthesis    area    knockouts    ways    informatic    competitive    acquire    acid    engineered    recruit    bio    engineering    researcher    efficient    structures    designed    drug    assembly    fatty    domains    family    drugs    carboxylase    precursor    significantly    realising    gain    substrate    bearing    line   

Project "CaLiAT" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

The development and spread of antibiotic resistance in microorganisms is a major threat to both humans and animals and the search for new and improved drugs is of high importance. Natural products are experiencing a strong revival as leads in drug development, and biosynthetic engineering offers sustainable routes to new and potentially improved analogues. Finding new ways to make these rational changes should ensure that the European Research Area remains competitive in realising the potential of this technology. The aim of this project is to gain a detailed understanding of a newly-identified family of enzymes supplying unusual fatty acid building blocks for assembly-line biosynthesis of natural products; and to exploit these insights to develop more efficient strategies for targeted alteration of their structures. The novel precursor enzymes to be studied, a ligase and a biotin-dependent carboxylase, are in pathways to several polyketides produced by actinomycete bacteria. The project divides into three parts. First, additional examples of the new pathway will be sought by targetted whole-genome sequencing, as well as bio-informatic analysis of published sequence databases, and gene knockouts used to confirm the role of the pathway in providing polyketide extender units. Secondly, candidate ligases, carboxylases and the cognate acyltransferase domains that specifically recruit the unusual extender units will be studied in vitro for substrate specificity and for their ability to accept non-natural substrates bearing chemical functionality. Finally, a range of non-natural fatty acids will be fed as precursors to engineered strains designed to produce novel polyketide analogues. This approach should significantly expand the available pool of polyketide diversity. At the same time, the researcher will acquire high-level training in biochemical and chemical biology approaches that will help equip her for a leadership role in research.

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The information about "CALIAT" are provided by the European Opendata Portal: CORDIS opendata.

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