Opendata, web and dolomites

CYgnaling SIGNED

Probing the role of orphan Cytochrome P450 oxygenases in signaling compounds biosynthesis in plants by a comparative genomics and gene conservation approach

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "CYgnaling" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.ibmp.cnrs.fr/equipes/cytochromes-p450-et-metabolismes-associes/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 185˙076.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

A limited number of molecules have been characterized as plant growth regulators or hormones, usually identified due to the strong effect that they exert on plant architecture or development. Most of the metabolic pathways leading to their biosynthesis and catabolism are now well characterized, and all but one involve oxygenases belonging to the family of cytochrome P450 (P450) oxygenases. The increasing set of sequenced plant genomes reveals the evolutionary history and complex phylogeny of the P450 superfamily. It shows that some P450 genes are specific to taxa or evolutionary branches, which correlates with the versatility of plant metabolomes when different species are compared. But comparative analysis of plant genomes also point to ancient genes, highly conserved and under strong purifying selection. Those are most often involved in the metabolism of molecules essential for plant development and with signaling function. Taking advantage of the increasing power of comparative genomics, we propose to identify P450s that share similar evolutionary characteristics with their counterparts in known hormone metabolism. We propose to perform a comprehensive functional analysis of a set of candidates, using the easiest plant model Arabidopsis thaliana, and to assess their role in the biosynthesis or degradation of signaling compounds. This includes establishing a detail map of candidates’ expressions to evaluate their place and time of action, and a phenotypic analysis of inactivation mutants and overexpressors to assess the consequences of gene misexpression on plant development. Based on gene expression and potential mutant phenotypes, we will select tissues to be analyzed for metabolic changes associated with gene mutation using high-definition analytical tools. Enzyme activity will be assessed with recombinant proteins. We are confident that this innovative multidisciplinary approach will be a powerful tool to identify new and overlooked plant signaling pathways.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CYGNALING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CYGNALING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EcoSpy (2018)

Leveraging the potential of historical spy satellite photography for ecology and conservation

Read More  

Migration Ethics (2019)

Migration Ethics

Read More  

GENESIS (2020)

unveilinG cEll-cell fusioN mEdiated by fuSexins In chordateS

Read More