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SSHelectPhagy SIGNED

Regulation of Selective autophagy by sulfide through persulfidation of protein targets.

Total Cost €

EC-Contrib. €

Partnership

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SSHelectPhagy project word cloud

Explore the words cloud of the SSHelectPhagy project. It provides you a very rough idea of what is the project "SSHelectPhagy" about.

broaden mediated metabolism functions iowa mechanisms selective ibvf supervision proteins researcher acts shed persulfidation light gotor contributes autophagosome machinery yeast 12 contribution fellowship emerged cargo hydrogen h2s seville months plants binding homeostasis cellular prevent critically return signaled plant bassham reticulophagy reproduction unknown mitophagy links degrading selectively mammals life cells prof modified atg damaged macromolecules nutrient toxic degradation resistance intracellular mainly ribosomes autophagy photosynthesis dr mitochondria inhibitor adaptor university seedling regulation er deprivation aggregated sulfide host conserved toxicity underlying establishment mechanism pathogens stress biochemistry

Project "SSHelectPhagy" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE SEVILLA Organization address address: CALLE S. FERNANDO 4 city: SEVILLA postcode: 41004 website: www.us.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	175˙099 €
EC max contribution	175˙099 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-GF
Starting year	2019
Duration (year-month-day)	from 2019-06-15 to 2021-06-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE SEVILLA UNIVERSIDAD DE SEVILLA Organization address address: CALLE S. FERNANDO 4 city: SEVILLA postcode: 41004 website: www.us.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SEVILLA)	coordinator	175˙099.00
2	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY Organization address address: BEARDSHEAR HALL 1750 city: AMES postcode: IA50011 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (AMES)	partner	0.00

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Project objective

The researcher will address the contribution of sulfide to regulation of selective autophagy in plants through persulfidation. This fellowship will be carried out at Iowa State University under the supervision of Prof. Bassham. The researcher will return to the European host, the University of Seville for 12 months under the supervision of Dr.Gotor at the Institute of Plant Biochemistry and Photosynthesis (IBVF). This project aims at understanding of selective autophagy regulation by sulfide in plants. Autophagy has conserved functions in development, cellular homeostasis, and stress responses from yeast to plants and mammals. In plants, autophagy is critically important in many aspects of plant life, including seedling establishment, plant development, stress resistance, metabolism and reproduction. It contributes to intracellular homeostasis in cells by selectively degrading aggregated proteins, damaged mitochondria, ribosomes, toxic macromolecules, and pathogens to prevent toxicity. This selective autophagy is mediated by the binding of adaptor proteins, which links a cargo targeted for degradation to the autophagosome machinery. An increasing number of targets for selective autophagy under different stress conditions have emerged in recent years, but the underlying mechanisms of their regulation are still so far unknown. Hydrogen sulfide (H2S) acts as an inhibitor of autophagy induced by nutrient deprivation and its mechanism has been proposed to be through persulfidation of specific targets. Several autophagy (ATG)-related proteins have been identified as modified by persulfidation in previous studies. The overall aim of this project is to shed light to the role of sulfide in the regulation of selective autophagy, mainly of mitochondria and ER, through persulfidation, and to broaden the range of plant targets for mitophagy and reticulophagy that are signaled by sulfide.

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The information about "SSHELECTPHAGY" are provided by the European Opendata Portal: CORDIS opendata.