NanoPorous DNA-array
Ultra-high density three dimentional DNA arrays for biosensing
Total Cost €
0EC-Contrib. €
0Partnership
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Project "NanoPorous DNA-array" data sheet
The following table provides information about the project.
| Coordinator |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Project website | http://www.lbb.ethz.ch/the-group/people/person-details.html |
| Total cost | 187˙419 € |
| EC max contribution | 187˙419 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2018-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH | CH (ZUERICH) | coordinator | 187˙419.00 |
Map
Project objective
Extra cellular, circulating nucleic acids – such as DNA or RNA – have been found as important biomarkers for identification and diagnosis of cancer and other diseases However, the detection of circulating nucleic acids is non-trivial because they often exist at very low concentrations in large volumes of body fluids. Although many attempts have been tried for the detection of these biomarkers in recent years, including various nanostructure based sensors, there is still no approach in sight that could reach the desired sensitivity. Hence, there is a great need for a sensor which can effectively detect the diagnostically relevant (low) concentrations of circulating nucleic acids with a high degree of selectivity and sensitivity. In this project we propose a new platform for detection of nucleic acids; the aim of this project is to achieve a multi-layered filtering device, which allows effective filtration, purification and detection of biomolecules from complex biofluids. The platform is based on implementation of ultra-high density 3D DNA arrays - which are made on a functionalized nanoporous substrate (nanoporous anodic aluminium oxide) – into a microfluidic device assay (so called FoRe assay, i.e combination of Forward and Reverse assays, which is consist of multiple filters, each capable of capturing specific target biomarkers from different sample). Pores are able capture the target molecules because locally the concentration of even a single target molecule in the pore is sufficient for binding and hybridization. The captured target molecules can then be detected by subsequent specific labeling using DNA-tagged gold nanoparticles (via hybridization), which will allow detection with single molecule sensitivity. If successful, the scalable system will be used as a point-of-care diagnostic platform in the future.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Morteza Aramesh, Phong A. Tran, Kostya (Ken) Ostrikov, Steven Prawer Conformal nanocarbon coating of alumina nanocrystals for biosensing and bioimaging published pages: 422-427, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2017.06.101 |
Carbon 122 | 2019-06-13 |
| 2018 |
Raphael F. Tiefenauer, Klas Tybrandt, Morteza Aramesh, János Vörös Fast and Versatile Multiscale Patterning by Combining Template-Stripping with Nanotransfer Printing published pages: 2514-2520, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b08290 |
ACS Nano 12/3 | 2019-04-18 |
| 2018 |
Morteza Aramesh Ion-Beam Sculpting of Nanowires published pages: 1700333, ISSN: 1862-6254, DOI: 10.1002/pssr.201700333 |
physica status solidi (RRL) - Rapid Research Letters 12/1 | 2019-04-18 |
| 2018 |
Raphael F. Tiefenauer, Thomas Dalgaty, Tobias Keplinger, Tian Tian, Chih-Jen Shih, János Vörös, Morteza Aramesh Monolayer Graphene Coupled to a Flexible Plasmonic Nanograting for Ultrasensitive Strain Monitoring published pages: 1801187, ISSN: 1613-6810, DOI: 10.1002/smll.201801187 |
Small 14/28 | 2019-04-18 |
| 2018 |
Morteza Aramesh, Yashar Mayamei, Annalena Wolff, Kostya Ostrikov Superplastic nanoscale pore shaping by ion irradiation published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03316-7 |
Nature Communications 9/1 | 2019-04-18 |
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