Explore the words cloud of the SUPRABIOTICS project. It provides you a very rough idea of what is the project "SUPRABIOTICS" about.
The following table provides information about the project.
Coordinator |
RIJKSUNIVERSITEIT GRONINGEN
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Total cost | 2˙500˙000 € |
EC max contribution | 2˙500˙000 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-AdG |
Funding Scheme | ERC-ADG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-09-01 to 2021-08-31 |
Take a look of project's partnership.
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1 | RIJKSUNIVERSITEIT GRONINGEN | NL (GRONINGEN) | coordinator | 2˙500˙000.00 |
The pharmaceutical sector has a huge demand for new active compounds including natural products to fill the drug pipelines and to stop the global decline in novel approved active pharmaceutical ingredients. Therefore, developing new tools to fabricate complex molecular structures in a fast and reliable way is paramount. This holds especially true for the field of antibiotics. Multidrug resistant (MDR) pathogens evolve at a terrifying rate and confer resistance to all presently available antibacterial treatments and therefore WHO has identified MDR bacteria as major threat to human health.
In this ERC Advanced Grant, I propose a radically new approach to fabricate very complex molecules with minimal synthetic effort. The technology is based on nucleic acid binders (aptamers), which are evolved in a selection protocol and block several functional groups within a target molecule while allowing other functionalities not in contact with the aptamer to be selectively modified in a single reaction step. Here, we aim to establish this groundbreaking aptameric protective group (APG) method as a novel tool that gives access to compounds that would otherwise be too difficult to obtain by multistep synthesis. Toward this end, the specific objectives are:
• To develop reagents and reactions that are compatible with aptamer-mediated reactions • To control the site of chemical modification within complex molecules by APGs • To establish APGs as a general paradigm in natural product derivatization to modify several kinds of substrates • To achieve site selective modification of proteins by aptamers • To synthesize novel antibiotics that kill MDR bacteria • To fabricate “image-and-activate” antibiotics by the APG technology • To employ the aptamer-target complexes for live-cell imaging of RNA
The outcomes will enable future advances in drug discovery and drug design, bioimaging technologies, and the site-specific modification of therapeutic proteins.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Lei Zhang, Lifei Zheng, Zhuojun Meng, Konstantin Balinin, Mark Loznik, Andreas Herrmann Accelerating chemical reactions by molecular sledding published pages: 6331-6334, ISSN: 1359-7345, DOI: 10.1039/C7CC02500A |
Chemical Communications 53/47 | 2019-06-13 |
2017 |
Kai Liu, Chao Ma, Robert Göstl, Lei Zhang, Andreas Herrmann Liquefaction of Biopolymers: Solvent-free Liquids and Liquid Crystals from Nucleic Acids and Proteins published pages: 1212-1221, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.7b00030 |
Accounts of Chemical Research 50/5 | 2019-06-13 |
2017 |
Lei Zhang, Sourav Maity, Kai Liu, Qing Liu, Robert Göstl, Giuseppe Portale, Wouter H. Roos, Andreas Herrmann Nematic DNA Thermotropic Liquid Crystals with Photoresponsive Mechanical Properties published pages: 1701207, ISSN: 1613-6810, DOI: 10.1002/smll.201701207 |
Small 13/34 | 2019-06-13 |
2017 |
Kai Liu, Lifei Zheng, Chao Ma, Robert Göstl, Andreas Herrmann DNA–surfactant complexes: self-assembly properties and applications published pages: 5147-5172, ISSN: 0306-0012, DOI: 10.1039/C7CS00165G |
Chemical Society Reviews 46/16 | 2019-06-13 |
2018 |
Anouk S. Lubbe, Qing Liu, Sanne J. Smith, Jan Willem de Vries, Jos C. M. Kistemaker, Alex H. de Vries, Ignacio Faustino, Zhuojun Meng, Wiktor Szymanski, Andreas Herrmann, Ben L. Feringa Photoswitching of DNA Hybridization Using a Molecular Motor published pages: 5069-5076, ISSN: 0002-7863, DOI: 10.1021/jacs.7b09476 |
Journal of the American Chemical Society 140(15) | 2019-06-13 |
2018 |
Alessio Marcozzi, Tiziana Masini, Di Zhu, Diego Pesce, Boris Illarionov, Markus Fischer, Andreas Herrmann, Anna K. H. Hirsch Phage Display on the Anti-infective Target 1-Deoxy- d -xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor published pages: 58-65, ISSN: 1439-4227, DOI: 10.1002/cbic.201700402 |
ChemBioChem 19/1 | 2019-06-13 |
2019 |
Shuaidong Huo, Hongyan Li, Arnold J. Boersma, Andreas Herrmann DNA Nanotechnology Enters Cell Membranes published pages: 1900043, ISSN: 2198-3844, DOI: 10.1002/advs.201900043 |
Advanced Science 6/10 | 2019-06-06 |
2018 |
Esra te Brinke, Joost Groen, Andreas Herrmann, Hans A. Heus, Germán Rivas, Evan Spruijt, Wilhelm T. S. Huck Dissipative adaptation in driven self-assembly leading to self-dividing fibrils published pages: 849-855, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0192-1 |
Nature Nanotechnology 13/9 | 2019-06-06 |
2019 |
Jochem H. Smit, Jasper H. M. van der Velde, Jingyi Huang, Vanessa Trauschke, Sarah S. Henrikus, Si Chen, Nikolaos Eleftheriadis, Eliza M. Warszawik, Andreas Herrmann, Thorben Cordes On the impact of competing intra- and intermolecular triplet-state quenching on photobleaching and photoswitching kinetics of organic fluorophores published pages: 3721-3733, ISSN: 1463-9076, DOI: 10.1039/c8cp05063e |
Physical Chemistry Chemical Physics 21/7 | 2019-06-06 |
2018 |
Jian Yang, Zhuojun Meng, Qing Liu, Yasuhito Shimada, René C. L. Olsthoorn, Herman P. Spaink, Andreas Herrmann, Alexander Kros Performing DNA nanotechnology operations on a zebrafish published pages: 7271-7276, ISSN: 2041-6520, DOI: 10.1039/c8sc01771a |
Chemical Science 9/36 | 2019-06-06 |
2018 |
Lei Zhang, Chao Ma, Jing Sun, Baiqi Shao, Giuseppe Portale, Dong Chen, Kai Liu, Andreas Herrmann Genetically Engineered Supercharged Polypeptide Fluids: Fast and Persistent Self-Ordering Induced by Touch published pages: 6878-6882, ISSN: 1433-7851, DOI: 10.1002/anie.201803169 |
Angewandte Chemie International Edition 57/23 | 2019-06-06 |
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The information about "SUPRABIOTICS" are provided by the European Opendata Portal: CORDIS opendata.
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