Explore the words cloud of the HybCell project. It provides you a very rough idea of what is the project "HybCell" about.
The following table provides information about the project.
Coordinator |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Organization address contact info |
Coordinator Country | Switzerland [CH] |
Total cost | 1˙971˙250 € |
EC max contribution | 1˙971˙250 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-07-01 to 2021-06-30 |
Take a look of project's partnership.
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1 | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH | CH (ZUERICH) | coordinator | 1˙971˙250.00 |
The overall aim of the here described projects is to learn fundamental characteristics of cellular organization and compartmentalization, in particular the role of the lipid membrane, and to exploit this knowledge for engineering minimal cells with a great impact in the context of synthetic biology and also for pharmaceutical and medical applications. The first major objective aims at combining natural cell membranes with synthetic membranes to form defined hybrid systems with the size of cells or cell organelles. This approach has the intriguing advantage that the membrane receptors or channels are reconstituted in the hybrid cell and remain functional. In consequence, signaling pathways of a cell can be mimicked and therefore, the vesicles can be addressed similar to a cell or can serve as cell-free sensor. The second major objective addresses the challenge to build multi-compartment systems. In a defined number and formulation, smaller compartments are enclosed in a larger vesicle and carry other constituents than the lumen of the larger host vesicles (catalysts or enzymes, respectively; DNA; buffer systems; other active biomolecules). With the acquired fundamental knowledge on membrane permeability and fusion, multi-step reactions can be conducted, where several compartments are involved, just like in a living cell. The key methods to address these challenges are based on lab-on-chip technology that provide the unique potential to systematically investigate membrane properties by allowing precise formation, positioning, manipulation and analysis of the membranes; together with many more advantages such as the fast and controlled fluid supply, the possibility of tailoring the chemical surface patterns and surface topology and the application of electrical fields. Microfluidic platform will allow going far beyond the existing methods in membrane research, so that controlled bottom-up formation of simple to more and more complex systems becomes possible.
year | authors and title | journal | last update |
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2017 |
Ya Zhang, Yannick R. F. Schmid, Sandra Luginbühl, Qiang Wang, Petra S. Dittrich, Peter Walde Spectrophotometric Quantification of Peroxidase with p -Phenylene-diamine for Analyzing Peroxidase-Encapsulating Lipid Vesicles published pages: 5484-5493, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b00423 |
Analytical Chemistry 89/10 | 2019-06-18 |
2017 |
L. Armbrecht, G. Gabernet, F. Kurth, J. A. Hiss, G. Schneider, P. S. Dittrich Characterisation of anticancer peptides at the single-cell level published pages: 2933-2940, ISSN: 1473-0197, DOI: 10.1039/c7lc00505a |
Lab on a Chip 17/17 | 2019-06-18 |
2017 |
N. Nuti, P. E. Verboket, P. S. Dittrich Multivesicular droplets: a cell model system to study compartmentalised biochemical reactions published pages: 3112-3119, ISSN: 1473-0197, DOI: 10.1039/c7lc00710h |
Lab on a Chip 17/18 | 2019-06-18 |
2017 |
Bernhard Sebastian, Tobias Favero, Petra S. Dittrich The Effects of Shear Force Transmission Across Vesicle Membranes published pages: 6128-6134, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.7b02676 |
The Journal of Physical Chemistry Letters 8/24 | 2019-06-18 |
2016 |
Lucas Armbrecht, Petra S. Dittrich Recent Advances in the Analysis of Single Cells published pages: 2-21, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04255 |
Analytical Chemistry 89/1 | 2019-06-18 |
2017 |
Can Dincer, Richard Bruch, André Kling, Petra S. Dittrich, Gerald A. Urban Multiplexed Point-of-Care Testing – xPOCT published pages: 728-742, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2017.03.013 |
Trends in Biotechnology 35/8 | 2019-06-18 |
2017 |
S. Bachler, C.-Ch. Lin, C. Del Don, and P. S. Dittrich Combination of a microfluidic device and fluorescence correlation spectroscopy to study peptide translocation across model membranes published pages: 967-968, ISSN: , DOI: |
Proceedings of the microTAS conference Annual | 2019-06-18 |
2017 |
F. Kurth, O. G. Weingart, K. Eyer, M. J. Loessner, P. S. Dittrich Microfluidic liposome biosensor for detecting botulinum neurotoxin physiological activity published pages: 973-974, ISSN: , DOI: |
Proceedings of the microTAS conference Annual | 2019-06-18 |
2018 |
Phillip Kuhn, Klaus Eyer, Petra S. Dittrich A microfluidic device for the delivery of enzymes into cells by liposome fusion published pages: 149-156, ISSN: 1618-0240, DOI: 10.1002/elsc.201600150 |
Engineering in Life Sciences 18/2 | 2019-06-18 |
2017 |
Max Pillong, Jan A. Hiss, Petra Schneider, Yen-Chu Lin, Gernot Posselt, Bernhard Pfeiffer, Markus Blatter, Alex T. Müller, Simon Bachler, Claudia S. Neuhaus, Petra S. Dittrich, Karl-Heinz Altmann, Silja Wessler, Gisbert Schneider Rational Design of Membrane-Pore-Forming Peptides published pages: 1701316, ISSN: 1613-6810, DOI: 10.1002/smll.201701316 |
Small 13/40 | 2019-06-18 |
2018 |
Bernhard Sebastian, Petra S. Dittrich Microfluidics to Mimic Blood Flow in Health and Disease published pages: 483-504, ISSN: 0066-4189, DOI: 10.1146/annurev-fluid-010816-060246 |
Annual Review of Fluid Mechanics 50/1 | 2019-06-18 |
2018 |
Felix Kurth, Petra S. Dittrich, Peter Walde, Dieter Seebach Influence of the Membrane Dye R18 and of DMSO on Cell Penetration of Guanidinium-Rich Peptides published pages: e1800302, ISSN: 1612-1872, DOI: 10.1002/cbdv.201800302 |
Chemistry & Biodiversity 15/10 | 2019-04-17 |
2018 |
Yannick Schmid, Petra S. Dittrich Towards Artificial Cells: Electrofusion of Lipid Vesicles on-chip published pages: 1390-1392, ISSN: , DOI: |
Proceedings of the microTAS conference Annual | 2019-04-17 |
2018 |
Marcel Grogg, Donald Hilvert, Marc-Olivier Ebert, Albert K. Beck, Dieter Seebach, Felix Kurth, Petra S. Dittrich, Christof Sparr, Sergio Wittlin, Matthias Rottmann, Pascal Mäser Cell Penetration, Herbicidal Activity, and in-vivo -Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin published pages: e1800112, ISSN: 0018-019X, DOI: 10.1002/hlca.201800112 |
Helvetica Chimica Acta 101/10 | 2019-04-17 |
2018 |
Chao-Chen Lin, Michael Bachmann, Simon Bachler, Koushik Venkatesan, Petra S. Dittrich Tunable Membrane Potential Reconstituted in Giant Vesicles Promotes Permeation of Cationic Peptides at Nanomolar Concentrations published pages: 41909-41916, ISSN: 1944-8244, DOI: 10.1021/acsami.8b12217 |
ACS Applied Materials & Interfaces 10/49 | 2019-04-17 |
2018 |
Patrick Drücker, Simon Bachler, Heidi Wolfmeier, Roman Schoenauer, René Köffel, Viktoria S. Babiychuk, Petra S. Dittrich, Annette Draeger, Eduard B. Babiychuk Pneumolysin-damaged cells benefit from non-homogeneous toxin binding to cholesterol-rich membrane domains published pages: 795-805, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2018.04.010 |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863/8 | 2019-04-17 |
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