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NIRV_HOST_INT SIGNED

Population genomics of co-evolution between non-retroviral RNA viruses and their hosts

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NIRV_HOST_INT project word cloud

Explore the words cloud of the NIRV_HOST_INT project. It provides you a very rough idea of what is the project "NIRV_HOST_INT" about.

gene material correlations analysed nirv reverse implications albopictus hosts vector rna host dengue natural competence viral first public genetic systematic insights viruses coding transfer purposes phylogenetically nirvs therapy similarly mosquito aedes description model populations environment generational specificity ae dna flaviviruses line despite laboratory genome retroviruses flavivirus uncover interactions genomic geographic acquired recent integrase stability integrations health ideal additionally biology respective persistent context manipulated mechanisms unclear infection immunity flaviviridae permit evolutionary biological trans somatic levels germ infections retroviral secondly distributions population medicine interrogate transcriptase tissue establishment discoveries characterization

Project "NIRV_HOST_INT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI PAVIA Organization address address: STRADA NUOVA 65 city: PAVIA postcode: 27100 website: www.unipv.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.bonizzonilab.com
Total cost	1˙686˙875 €
EC max contribution	1˙686˙875 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-CoG
Funding Scheme	ERC-COG
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI PAVIA UNIVERSITA DEGLI STUDI DI PAVIA Organization address address: STRADA NUOVA 65 city: PAVIA postcode: 27100 website: www.unipv.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PAVIA)	coordinator	1˙466˙875.00
2	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	220˙000.00

Map

Project objective

Recent discoveries clearly show that non-retroviral RNA viruses, despite not coding for reverse transcriptase and integrase, can transfer genetic material to their hosts, similarly to DNA viruses and retroviruses. The distribution of non-retroviral integrated RNA viruses (NIRVs) in host populations, mechanisms of NIRVs formation and effects on hosts are unclear. The main objective of this proposal is to uncover the complex biological interactions between non-retroviral RNA viruses and their hosts using the model system “Aedes albopictus and Flavivirus”. This system is ideal because Ae. albopictus is a known vector of non-retroviral RNA viruses, including several highly relevant for public health such as dengue viruses (Flaviviridae, Flavivirus) and NIRVs phylogenetically related to Flaviviruses have been identified in its genome. First, a population genomic approach will be used to interrogate the genome of Ae. albopictus from different geographic populations at their DNA and RNA levels. This approach will permit the systematic characterization of the distributions of NIRVs in natural host populations, the analyses of correlations between the presence of NIRVs and viral infections and the description of NIRVs genomic context, from which insights on mechanisms of NIRVs formation can be derived. Secondly, tissue-specificity of the NIRVs, their trans-generational stability and impact on mosquito biology will be analysed in a controlled laboratory environment. Somatic integrations could contribute to acquired immunity to their respective viruses or establishment of persistent viral infection. Germ-line integrations could have an evolutionary impact. If NIRVs affect Ae. albopictus vector competence or the genome of emerging viral populations, they could be manipulated for vector control purposes. Additionally, results on NIRV distribution in natural host populations and mechanisms of NIRVs formation will have implications in medicine because several non-retroviral RNA viruses are emerging as delivery systems for gene therapy applications.

Publications

List of publications.
year	authors and title	journal	last update
2019	Francesca Scolari, Maurizio Casiraghi and Mariangela Bonizzoni Aedes spp. and Their Microbiota: A Review published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.02036	Frontiers in Microbiology	2020-03-11
2019	Michele Marconcini, Luis Hernandez, Giuseppe Iovino, Vincent HouÃ©, Federica Valerio, Umberto Palatini, Elisa Pischedda, Jacob Crawford, Rebeca Carballar-Lejarazu, Lino Ometto, Federico Forneris, Anna-Bella Failloux, Mariangela Bonizzoni Polymorphism analyses and protein modelling inform on functional specialization of Piwi clade genes in the arboviral vector Aedes albopictus published pages: , ISSN: 0000-0000, DOI: 10.1101/677062	BioRxiv	2020-03-11
2019	Vincent HouÃ©, Mariangela Bonizzoni, Anna-Bella Failloux Endogenous non-retroviral elements in genomes of Aedes mosquitoes and vector competence published pages: 542-555, ISSN: 2222-1751, DOI: 10.1080/22221751.2019.1599302	Emerging Microbes & Infections 8/1	2020-03-11
2019	Elisa Pischedda, Francesca Scolari, Federica Valerio, Rebeca Carballar-LejarazÃº, Paolo Luigi Catapano, Robert M. Waterhouse, Mariangela Bonizzoni Insights Into an Unexplored Component of the Mosquito Repeatome: Distribution and Variability of Viral Sequences Integrated Into the Genome of the Arboviral Vector Aedes albopictus published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00093	Frontiers in Genetics 10	2020-03-11
2018	Elisa Pischedda, Francesca Scolari, Federica Valerio, Rebeca CarballarLejarazÃº,Paolo Luigi Catapano ,RobertM.Waterhouse and Mariangela Bonizzoni Evolutionary landscape of mosquito viral integrations published pages: , ISSN: , DOI: 10.1101/385666		2020-03-11
2019	Carol D. Blair, Ken E. Olson, Mariangela Bonizzoni The Widespread Occurrence and Potential Biological Roles of Endogenous Viral Elements in Insect Genomes published pages: 13-30, ISSN: 1467-3037, DOI: 10.21775/cimb.034.013	Current Issues in Molecular Biology	2020-03-11
2017	Ken E Olson, Mariangela Bonizzoni Nonretroviral integrated RNA viruses in arthropod vectors: an occasional event or something more? published pages: 45-53, ISSN: 2214-5745, DOI: 10.1016/j.cois.2017.05.010	Current Opinion in Insect Science 22	2020-03-11
2019	Vincent HouÃ©, Gaelle Gabiane, Catherine Dauga, Marie Suez, Yoann Madec, Laurence Mousson, Michele Marconcini, Pei-Shi Yen, Xavier de Lamballerie, Mariangela Bonizzoni and Anna-Bella Failloux Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus published pages: , ISSN: 2222-1751, DOI: 10.1080/22221751.2019.1657785	Emerging Microbes and Infections	2020-03-11
2017	Umberto Palatini, Pascal Miesen, Rebeca Carballar-Lejarazu, Lino Ometto, Ettore Rizzo, Zhijian Tu, Ronald P. van Rij, Mariangela Bonizzoni Comparative genomics shows that viral integrations are abundant and express piRNAs in the arboviral vectors Aedes aegypti and Aedes albopictus published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-017-3903-3	BMC Genomics 18/1	2020-03-11

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