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BHIVE SIGNED

Bio-derived HIgh Value polymers through novel Enzyme function

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BHIVE project word cloud

Explore the words cloud of the BHIVE project. It provides you a very rough idea of what is the project "BHIVE" about.

organisms metagenome global biological enormous recent agricultural strategic uncharted environmentally politically genomics lignocellulose life assays polysaccharides bhive enzyme functions cells families forest realizing abundant regions sectors sustainable sequences biochemicals biophysical annotated societal sustainably discover transformation un screens phylogenetic sources trees active revealed 40 proteins undivided transcriptome unknown plants era human bioplastics encoded sequence renewable market genome time diverse constraint nearly poorly mapping benefits enterprise genomic tackles bioconversion illuminate plant science synthesize entirely limitations uncover chemistry biomaterials thrusts earth modify materials characterizing dark environmental lifestyles protein harness parallel function biomass live

Project "BHIVE" data sheet

The following table provides information about the project.

Coordinator	AALTO KORKEAKOULUSAATIO SR Organization address address: OTAKAARI 1 city: ESPOO postcode: 2150 website: http://www.aalto.fi/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Finland [FI]
Total cost	1˙977˙781 €
EC max contribution	1˙977˙781 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AALTO KORKEAKOULUSAATIO SR AALTO KORKEAKOULUSAATIO SR Organization address address: OTAKAARI 1 city: ESPOO postcode: 2150 website: http://www.aalto.fi/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	coordinator	1˙977˙781.00

Map

Project objective

Recent advances in systems-level study of cells and organisms have revealed the enormous potential to live more sustainably through better use of biological processes. Plants sustainably synthesize the most abundant and diverse materials on Earth. By applying recent advances in life science technology, we can better harness renewable plant resources and bioconversion processes, to develop environmentally and politically sustainable human enterprise and lifestyles. At the same time, the global market for high-value biochemicals and bioplastics from forest and agricultural sources is rapidly increasing, which presents new opportunities for forest and agricultural sectors.

The overall aim of BHIVE is to illuminate uncharted regions of genome and metagenome sequences to discover entirely new protein families that can be used to sustainably synthesize novel, high-value biomaterials from renewable plant resources. The approach will include three parallel research thrusts: 1) strategic analysis of transcriptome and metagenome sequences to identify proteins with entirely unknown function relevant to biomass (lignocellulose) transformation, 2) mapping of uncharted regions within phylogenetic trees of poorly characterized enzyme families with recognized potential to modify the chemistry and biophysical properties of plant polysaccharides, and 3) the design and development of novel enzyme screens to directly address the increasing limitations of existing assays to uncover entirely new protein functions. BHIVE will be unique in its undivided focus on characterizing lignocellulose-active proteins encoded by the 30-40% of un-annotated sequence, or genomic “dark matter”, typical of nearly all genome sequences. In this way, BHIVE tackles a key constraint to fully realizing the societal and environmental benefits of the genomics era.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ville Aumala, Filip Mollerup, Edita Jurak, Fabian Blume, Johanna Karppi, Antti E. Koistinen, Eva Schuiten, Moritz VoÃŸ, Uwe Bornscheuer, Jan Deska, Emma R. Master Biocatalytic Production of Amino Carbohydrates through Oxidoreductase and Transaminase Cascades published pages: 848-857, ISSN: 1864-5631, DOI: 10.1002/cssc.201802580	ChemSusChem 12/4	2020-03-05
2017	Galina Mai-Gisondi, Hannu Maaheimo, Sun-Li Chong, Sandra Hinz, Maija Tenkanen, Emma Master Functional comparison of versatile carbohydrate esterases from families CE1, CE6 and CE16 on acetyl-4- O -methylglucuronoxylan and acetyl-galactoglucomannan published pages: 2398-2405, ISSN: 0304-4165, DOI: 10.1016/j.bbagen.2017.06.002	Biochimica et Biophysica Acta (BBA) - General Subjects 1861/9	2020-03-05
2016	Filip Mollerup, Emma Master Influence of a family 29 carbohydrate binding module on the recombinant production of galactose oxidase in Pichia pastoris published pages: 176-183, ISSN: 2352-3409, DOI: 10.1016/j.dib.2015.11.032	Data in Brief 6	2019-09-27
2018	Fakhria M. Razeq, Edita Jurak, Peter J. Stogios, Ruoyu Yan, Maija Tenkanen, Mirjam A. Kabel, Weijun Wang, Emma R. Master A novel acetyl xylan esterase enabling complete deacetylation of substituted xylans published pages: , ISSN: 1754-6834, DOI: 10.1186/s13068-018-1074-3	Biotechnology for Biofuels 11/1	2019-09-27
2017	Mabel T. Wong, Weijun Wang, Marie Couturier, Fakhria M. Razeq, Vincent Lombard, Pascal Lapebie, Elizabeth A. Edwards, Nicolas Terrapon, Bernard Henrissat, Emma R. Master Comparative Metagenomics of Cellulose- and Poplar Hydrolysate-Degrading Microcosms from Gut Microflora of the Canadian Beaver (Castor canadensis) and North American Moose (Alces americanus) after Long-Term Enrichment published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.02504	Frontiers in Microbiology 8	2019-09-27
2018	Weijun Wang, Nikola Andric, Cody Sarch, Bruno T. Silva, Maija Tenkanen, Emma R. Master Constructing arabinofuranosidases for dual arabinoxylan debranching activity published pages: 41-49, ISSN: 0006-3592, DOI: 10.1002/bit.26445	Biotechnology and Bioengineering 115/1	2019-09-27
2017	Robyn E. Goacher, Erick J. Braham, Courtney L. Michienzi, Robert M. Flick, Alexander F. Yakunin, Emma R. Master Direct analysis by Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) reveals action of bacterial laccase-mediator system on both hardwood and softwood samples published pages: , ISSN: 0031-9317, DOI: 10.1111/ppl.12688	Physiologia Plantarum	2019-09-27
2018	Benjamin MacCormick, Thu V. Vuong, Emma R. Master Chemo-enzymatic Synthesis of Clickable Xylo-oligosaccharide Monomers from Hardwood 4- O -Methylglucuronoxylan published pages: 521-530, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01642	Biomacromolecules 19/2	2019-09-27
2017	Thu V. Vuong, Bing Liu, Mats Sandgren, Emma R. Master Microplate-Based Detection of Lytic Polysaccharide Monooxygenase Activity by Fluorescence-Labeling of Insoluble Oxidized Products published pages: 610-616, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.6b01790	Biomacromolecules 18/2	2019-09-27
2017	Kuisma Littunen, Galina Mai-Gisondi, Jukka SeppÃ¤lÃ¤, Emma R. Master Enzymatically Debranched Xylans in Graft Copolymerization published pages: , ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00229	Biomacromolecules	2019-09-27
2017	Galina Mai-Gisondi, Emma R. Master Colorimetric Detection of Acetyl Xylan Esterase Activities published pages: 45-57, ISSN: , DOI: 10.1007/978-1-4939-6899-2_5	Methods in Molecular Biology	2019-09-27

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