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LEPVORS SIGNED

Identification and characterization of new drug resistance and host adaptation mechanisms in Mycobacterium leprae

Total Cost €

EC-Contrib. €

Partnership

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LEPVORS project word cloud

Explore the words cloud of the LEPVORS project. It provides you a very rough idea of what is the project "LEPVORS" about.

media biological mycobacteria phenotype multiform molecular 25 mutated functions species resistance link form 2018 assume phenotypes reasonable obtain tools version anexic uncultivable sequencing 154 genomes caused modification host genes led fadd9 linked modulation genome genetic efficient innate surrogate possibility mutations tuberculosis bacleprosy immune representative probably tuberculoid functionally rate represented bacteria specific strain ribd chronic physiopathology drug infection slow hypermutated disease generation countries leprae proposes candidates susceptibility pole clinical haemophilum coding pathogen strains mycobacterium differences ml0411 forms leprosy resistant outcome mycobacterial wild

Project "LEPVORS" data sheet

The following table provides information about the project.

Coordinator	SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT Organization address address: SOCINSTRASSE 57 city: Basel postcode: CH-4002 website: www.swisstph.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	153˙916 €
EC max contribution	153˙916 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-GF
Starting year	2019
Duration (year-month-day)	from 2019-05-01 to 2022-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT Organization address address: SOCINSTRASSE 57 city: Basel postcode: CH-4002 website: www.swisstph.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Basel)	coordinator	153˙916.00
2	BOARD OF GOVERNORS OF THE COLORADO STATE UNIVERSITY SYSTEM BOARD OF GOVERNORS OF THE COLORADO STATE UNIVERSITY SYSTEM Organization address address: COLORADO STATE UNIVERSITY city: FORT COLLINS postcode: 80523 2001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (FORT COLLINS)	partner	0.00

Map

Project objective

Leprosy is a multiform infection caused by Mycobacterium leprae, an uncultivable bacLeprosy is a slow and chronic infection caused by Mycobacterium leprae. Recent advances in the next generation sequencing offer a new possibility to study the physiopathology of M. leprae, an uncultivable bacteria on anexic media. In 2018, the comparative analysis of 154 M. leprae genomes from 25 countries identified three hypermutated genes including two (ribD and fadD9) probably associated with drug-resistant and the most mutated one being ml0411 with a potential role in host adaptation. In a mycobacterial species, like M. leprae, with such a reduced number of coding genes, it is reasonable to assume that this high rate of mutations probably led to the modification of essential biological functions. In addition, the recent development of more efficient molecular tools can now help to obtain the whole genome sequencing of the strain from the low representative forms of the disease. This could help to identify more of these highly mutated genes and establish a link between the pathogen genetic and the clinical disease outcome. This project proposes to functionally characterize some of the mutations identified but also to identify new candidates which could be linked with differences in host phenotype. The study has three specific aims: Specific aim 1 will focus on potential new genes involved in M. leprae drug resistance. Using surrogate mycobacteria such as M. tuberculosis and M. haemophilum, we will test the drug susceptibility of mutated strains in fadD9 and ribD compared to wild-type strains. In specific aim 2, we will investigate the role of ml0411 and mutated version on the host innate immune response modulation In specific aim 3, we will focus on the whole genome sequencing of M. leprae strain from the less represented clinical form of leprosy, the tuberculoid pole to identify new genetic differences in the bacteria which could be associated with different host phenotypes.

Publications

List of publications.
year	authors and title	journal	last update
2020	Katharina RÃ¶ltgen, Gerd Pluschke, John Stewart Spencer, Patrick Joseph Brennan, Charlotte Avanzi The immunology of other mycobacteria: M. ulcerans, M. leprae published pages: , ISSN: 1863-2297, DOI: 10.1007/s00281-020-00790-4	Seminars in Immunopathology	2020-03-05

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The information about "LEPVORS" are provided by the European Opendata Portal: CORDIS opendata.