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GIANTSYN SIGNED

Biophysics and circuit function of a giant cortical glutamatergic synapse

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GIANTSYN project word cloud

Explore the words cloud of the GIANTSYN project. It provides you a very rough idea of what is the project "GIANTSYN" about.

run question circuit transsynaptic shape neuroscience history pyramidal microscopy learning axons placed subcellular vivo preand synaptic basic synapse recording first brainstem dendrites patch presynaptic dentate gyrus neurons granule investigation clamp models elucidate levels biophysics direct complexity freezing accessible peripheral ideal complete combine hypotheses brain previously postsynaptic plasticity cells memory diagnosis giantsyn electrophysiology mechanisms size rigorous ca3 function connectivity structural rules fundamental biophysical perspectives network hippocampal diseases interdisciplinary mossy impaired electron formed understand fiber communication transmission computations enigmatic synapses center treatment unravel labeling functional pressure

Project "GIANTSYN" data sheet

The following table provides information about the project.

Coordinator	INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Organization address address: Am Campus 1 city: KLOSTERNEUBURG postcode: 3400 website: www.ist.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	2˙677˙500 €
EC max contribution	2˙677˙500 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Organization address address: Am Campus 1 city: KLOSTERNEUBURG postcode: 3400 website: www.ist.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (KLOSTERNEUBURG)	coordinator	2˙677˙500.00

Map

Project objective

A fundamental question in neuroscience is how the biophysical properties of synapses shape higher network computations. The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is the ideal synapse to address this question. This synapse is accessible to presynaptic recording, due to its large size, allowing a rigorous investigation of the biophysical mechanisms of transmission and plasticity. Furthermore, this synapse is placed in the center of a memory circuit, and several hypotheses about its network function have been generated. However, even basic properties of this key communication element remain enigmatic. The ambitious goal of the current proposal, GIANTSYN, is to understand the hippocampal mossy fiber synapse at all levels of complexity. At the subcellular level, we want to elucidate the biophysical mechanisms of transmission and synaptic plasticity in the same depth as previously achieved at peripheral and brainstem synapses, classical synaptic models. At the network level, we want to unravel the connectivity rules and the in vivo network function of this synapse, particularly its role in learning and memory. To reach these objectives, we will combine functional and structural approaches. For the analysis of synaptic transmission and plasticity, we will combine direct preand postsynaptic patch-clamp recording and high-pressure freezing electron microscopy. For the analysis of connectivity and network function, we will use transsynaptic labeling and in vivo electrophysiology. Based on the proposed interdisciplinary research, the hippocampal mossy fiber synapse could become the first synapse in the history of neuroscience in which we reach complete insight into both synaptic biophysics and network function. In the long run, the results may open new perspectives for the diagnosis and treatment of brain diseases in which mossy fiber transmission, plasticity, or connectivity are impaired.

Publications

List of publications.
year	authors and title	journal	last update
2016	Nicholas P Vyleta, Carolina Borges-Merjane, Peter Jonas Plasticity-dependent, full detonation at hippocampal mossy fiberâ€“CA3 pyramidal neuron synapses published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.17977	eLife 5	2020-03-20
2017	Chong Chen, Rachel Satterfield, Samuel M. Young, Peter Jonas Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses published pages: 2082-2089, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.10.122	Cell Reports 21/8	2020-03-20
2018	Hua Hu, Fabian C. Roth, David Vandael, Peter Jonas Complementary Tuning of Na + and K + Channel Gating Underlies Fast and Energy-Efficient Action Potentials in GABAergic Interneuron Axons published pages: 156-165.e6, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.02.024	Neuron 98/1	2020-03-20

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