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AMECRYS SIGNED

Revolutionising Downstream Processing of Monoclonal Antibodies by Continuous Template-Assisted Membrane Crystallization

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

AMECRYS project word cloud

Explore the words cloud of the AMECRYS project. It provides you a very rough idea of what is the project "AMECRYS" about.

compliance chromatography storage ca mabs capacity flow combination nanotemplates protein biological microfluidic single antibodies recognition 25000 crystallization solutions largely manufacture synthesis proteins template crystallizer fold membrane 66 prototype of preserved purity biopharmaceuticals pharma fermentation revolutionize selective purification network replacement recognitions operations unprecedented molecular innovative visionary nucleation 3d broth membranes manufacturing binding multilevel footprint buffer media gmp continuous downstream qs designed disadvantages formulation total chip screening macroporous eur usually reuse efficiencies time throughput separation cancer intense nanotemplate fluoropolymer platform paradigm solid commercial amecrys batch resin assisted anti dsp chromatographically gt capex 60 monoclonal heterogeneous mab instance decrease

Project "AMECRYS" data sheet

The following table provides information about the project.

Coordinator	CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.amecrys-project.eu/
Total cost	3˙533˙813 €
EC max contribution	3˙533˙813 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2014-2015-RIA
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	coordinator	608˙073.00
2	CENTRE FOR PROCESS INNOVATION LIMITED LBG CENTRE FOR PROCESS INNOVATION LIMITED LBG Organization address address: WILTON CENTRE WILTON city: REDCAR CLEVELAND postcode: TS10 4RF website: www.uk-cpi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (REDCAR CLEVELAND)	participant	705˙015.00
3	UNIVERSITA DELLA CALABRIA UNIVERSITA DELLA CALABRIA Organization address address: VIA PIETRO BUCCI 7/11/B city: ARCAVACATA DI RENDE postcode: 87036 website: www.unical.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ARCAVACATA DI RENDE)	participant	375˙000.00
4	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	368˙125.00
5	UNIVERSITY OF STRATHCLYDE UNIVERSITY OF STRATHCLYDE Organization address address: Richmond Street 16 city: GLASGOW postcode: G1 1XQ website: www.strath.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	335˙500.00
6	UNIVERSITE LIBRE DE BRUXELLES UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	299˙375.00
7	GVS S.P.A. GVS S.P.A. Organization address address: Via Roma 50 city: ZOLA PREDOSA (BO) postcode: 40069 website: www.gvs.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ZOLA PREDOSA (BO))	participant	291˙250.00
8	FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED Organization address address: BELASIS AVENUE city: BILLINGHAM postcode: TS23 1LH website: www.fujifilmdiosynth.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BILLINGHAM)	participant	277˙359.00
9	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	274˙115.00

Map

Project objective

Separation and purification of biopharmaceuticals is today one of the most time and cost intense Downstream Processing (DSP) operations in the manufacture of commercial products. Separation and purification of proteins is usually achieved chromatographically, with all of its disadvantages including high buffer requirements, large footprint, reuse and storage of resin studies as well as costs. Traditional DSP based on batch chromatography contribute ca. 66% of the total production cost of anti-cancer monoclonal antibodies (mAbs). Largely contributing to this is the cost of chromatography media; for instance, the cost of 1 L of protein A resin with binding capacity of 20-70 g mAb is about 25000 Eur. By a visionary and ambitious combination of the emerging Continuous Manufacturing Paradigm with innovative Membrane Crystallization Technology and the selective nanotemplate-recognitions directly from the fermentation broth, the AMECRYS Network aims to develop a new Continuous Template-Assisted Membrane Crystallizer in order to revolutionize the DSP platform for mAbs production, thus achieving unprecedented purification and manufacturing efficiencies. Major research challenges will include: i) the synthesis of 3D-nanotemplates with specific molecular recognition ability towards mAbs from complex solutions; ii) the development of tailored macroporous fluoropolymer membranes for advanced control of selective heterogeneous nucleation; iii) the design of multilevel microfluidic devices for high-throughput mAb crystallization screening in a wide range of conditions under continuous flow (“pharma-on-a-chip” concept); iv) technology scale-up to a L-scale continuous prototype designed with recognition of QS/GMP compliance for biopharmaceuticals. The replacement of chromatography with a single membrane-crystallization unit will lead to >60% CapEx and O&M costs decrease, 30-fold footprint reduction and high-purity solid formulation of mAbs with preserved biological activity.

Deliverables

List of deliverables.
Communication events	Websites, patent fillings, videos etc.	2019-11-19 09:11:15
HEL4 domain fragment & Anti CD20 mAb process specification report	Documents, reports	2019-11-19 09:11:15
Open-source MC-FFS computational simulation packages	Other	2019-11-19 09:11:15
Robust microfabrication protocols to embed hydrophobic fluoropolymers membranes within microfluidic chips	Documents, reports	2019-11-19 09:11:14
Simulation code for thermodynamics of course-grained model of mAbs in confined geometry	Other	2019-11-19 09:11:14
Website and project logo	Websites, patent fillings, videos etc.	2019-11-19 09:11:14
Dissemination and Exploitation Plan	Documents, reports	2019-11-19 09:11:14
Report on preparation of nanotemplates for mAb crystallization	Documents, reports	2019-11-19 09:11:14
Data Management Plan	Open Research Data Pilot	2019-11-19 09:11:14

Take a look to the deliverables list in detail: detailed list of AMECRYS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Huaiyu Yang, Benny Danilo Belviso, Xiaoyu Li, Wenqian Chen, Teresa Fina Mastropietro, Gianluca Di Profio, Rocco Caliandro, Jerry Y. Y. Heng Optimization of Vapor Diffusion Conditions for Anti-CD20 Crystallization and Scale-Up to Meso Batch published pages: 230, ISSN: 2073-4352, DOI: 10.3390/cryst9050230	Crystals 9/5	2019-11-19
2018	Carmen Meringolo, Teresa F. Mastropietro, Teresa Poerio, Enrica Fontananova, Giovanni De Filpo, Efrem Curcio, Gianluca Di Profio Tailoring PVDF Membranes Surface Topography and Hydrophobicity by a Sustainable Two-Steps Phase Separation Process published pages: 10069â€“10077, ISSN: 2168-0485, DOI: 10.1021/acssuschemeng.8b01407	ACS Sustainable Chemistry & Engineering Number 6, Issue 8	2019-11-19
2018	Julien Lam, James F. Lutsko Lattice induced crystallization of nanodroplets: the role of finite-size effects and substrate properties in controlling polymorphism published pages: 4921-4926, ISSN: 2040-3364, DOI: 10.1039/c7nr08705e	Nanoscale 10/10	2019-11-19
2018	James F. Lutsko, Julien Lam Classical density functional theory, unconstrained crystallization, and polymorphic behavior published pages: 12604, ISSN: 2470-0045, DOI: 10.1103/PhysRevE.98.012604	Physical Review E 98/1	2019-11-19
2018	Julien Lam, James F. Lutsko Solvent-mediated interactions between nanostructures: From water to Lennard-Jones liquid published pages: 134703, ISSN: 0021-9606, DOI: 10.1063/1.5037571	The Journal of Chemical Physics 149/13	2019-11-19
2017	Julien Lam, James F. Lutsko Solute particle near a nanopore: influence of size and surface properties on the solvent-mediated forces published pages: 17099-17108, ISSN: 2040-3364, DOI: 10.1039/C7NR07218J	Nanoscale 9/43	2019-11-19

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