MERC TERMINATED
Molecular mechanisms regulating cardiovascular remodeling by Adamts1
Total Cost €
0EC-Contrib. €
0Partnership
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Project "MERC" data sheet
The following table provides information about the project.
| Coordinator |
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Total cost | 170˙121 € |
| EC max contribution | 170˙121 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-06-01 to 2019-11-15 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) | ES (MADRID) | coordinator | 170˙121.00 |
Map
Project objective
Professor Redondo’s group has recently identified Adamts1 as one of the major mediators in vascular wall remodeling. They showed that Adamts1/-, Adamts1-/- and KD-Adamts1 mice present aortic dilation, aneurysms, medial degeneration and hypotension, leading to the hypothesis that Adamts1 deficiency results in a new familial form of thoracic aortic aneurysm (FTAAD) potentially relevant in human aortic disease. They have also found that nitric oxide synthase (NOS) inhibitors reverse aortic dilation and medial degeneration in Marfan mice and Adamts1-deficient mice. The objective of my project is to study the molecular mechanisms mediating these aortic diseases in mice, and to specifically assess the role of nitric oxide (NO) and related signaling pathways, including those of Adamts1 and its substrates, in the medial degeneration and aortic dilation in both mouse models. I plan to identify potential targets common to both aortopathies and analyze them in patients with syndromic and non-syndromic aortic diseases. I think this project has a strong potential to identify therapeutic targets and prognostic or diagnostic markers for human cardiovascular diseases that constitute one of the major causes of mortality worldwide.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Jorge Oller, Nerea Méndez-Barbero, E Josue Ruiz, Silvia Villahoz, Marjolijn Renard, Lizet I Canelas, Ana M Briones, Rut Alberca, Noelia Lozano-Vidal, MarÃa A Hurlé, Dianna Milewicz, Arturo Evangelista, Mercedes Salaices, J Francisco Nistal, Luis Jesús Jiménez-Borreguero, Julie De Backer, Miguel R Campanero, Juan Miguel Redondo Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome published pages: 200-212, ISSN: 1078-8956, DOI: 10.1038/nm.4266 |
Nature Medicine 23/2 | 2019-05-27 |
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