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OBEDIA-MARK SIGNED

EPIGENETIC MARKERS OF DISEASE STATUS AND REVERSAL FOR PERSONALIZED MANAGEMENT OF OBESITY AND DIABETES

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

OBEDIA-MARK project word cloud

Explore the words cloud of the OBEDIA-MARK project. It provides you a very rough idea of what is the project "OBEDIA-MARK" about.

epigenetics maturity memories hosting randomized longitudinal expertise status diet time validity scientist me medicine disorders faculty expand diseases dnam reinforce disease biomarkers securing first life dietary weight hold skills subjects diabetes marks prediction arrangements cell intervention store independent lifestyle epigenetic experiences thanks markers consideration interactions outcomes property pertinent reversibility patterns combination 400 alone interact arising gene overweight fill genetic attain collaborations drive performance environment dna position professional innovation realizing methylation human reversal obese equip quality personalized gap relationship obesity

Project "OBEDIA-MARK" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	243˙208 €
EC max contribution	243˙208 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-GF
Starting year	2016
Duration (year-month-day)	from 2016-06-20 to 2019-06-19

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	243˙208.00
2	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Organization address address: SERRA MALL 450 city: STANFORD postcode: 94305 2004 website: www.stanford.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (STANFORD)	partner	0.00

Map

Project objective

Epigenetic marks such as DNA methylation (DNAm) can store cell memories of past life experiences. Thanks to this property, these marks hold great potential as biomarkers for personalized management of diseases arising from gene-environment interactions such as obesity and associated disorders. However, realizing this potential requires large-scale longitudinal studies that evaluate epigenetic markers under consideration of pertinent lifestyle and genetic factors. The goal of the proposed project is to fill this research gap by identifying, for the first time in a large-scale longitudinal study, epigenetic biomarkers of disease status and reversal for personalized management of obesity and diabetes. To attain this goal I will i) Identify overweight -associated DNAm markers by comparing DNAm patterns of 400 obese subjects before and after a randomized controlled weight-loss intervention, ii) Assess the relationship of the identified markers with gene-diet interactions, and their reversibility in response to weight-loss, iii) Test the validity of these markers, alone and in combination with genetic analysis, as biomarkers for prediction of weight-loss performance and diabetes status/reversal.

Expected outcomes: I) Drive innovation in personalized medicine by identifying epigenetic markers of disease status and reversal in obesity and diabetes, ii) Expand our understanding of how epigenetic, genetic and dietary factors interact with each other in the development and reversal of obesity, iii) Equip me with the knowledge and skills needed to become an independent scientist. The quality of the research, hosting arrangements and collaborations will provide me with the best opportunities to expand my expertise in epigenetics, apply it to research on human disease, and reinforce my professional maturity for securing a faculty position in Europe.

Publications

List of publications.
year	authors and title	journal	last update
2019	Cynthia W Shih, Michelle E Hauser, Lucia Aronica, Joseph Rigdon, Christopher D Gardner Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial published pages: 433-441, ISSN: 0002-9165, DOI: 10.1093/ajcn/nqy305	The American Journal of Clinical Nutrition 109/2	2019-10-17
2019	Cynthia W Shih, Michelle E Hauser, Lucia Aronica, Joseph Rigdon, Christopher D Gardner Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial published pages: 433-441, ISSN: 0002-9165, DOI: 10.1093/ajcn/nqy305	The American Journal of Clinical Nutrition 109/2	2019-06-06

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The information about "OBEDIA-MARK" are provided by the European Opendata Portal: CORDIS opendata.