Opendata, web and dolomites

LSD-CortLVPC SIGNED

Applying voltage-imaging techniques to visualise the effect of lysergic acid diethylamide (LSD) on cortical layer V pyramidal cells and its adaptation during tolerance development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LSD-CortLVPC project word cloud

Explore the words cloud of the LSD-CortLVPC project. It provides you a very rough idea of what is the project "LSD-CortLVPC" about.

health    elucidate    postulated    imminent    glutamate    layer    agents    scientifically    psych    pfel    living    techniques    cells    lsd    drugs    triangle    hallucinogens    investigations    networks    desynchronise    pathophysiology    shg    lvpcs    scientific    cortical    observations    modern    combines    acid    expertise    disconnect    area    lvpc    activation    benefit    basis    promotors    mediated    serotonergic    pivot    ht2a    selective    pose    relevance    threat    accounted    2a    hallucinogen    voltage    gained    optogenetic    sensitive    politics    thomas    psychoactive    cortex    excitability    submissiveness    ouml    vitro    action    neuropharmacological    applies    pioneering    buchborn    waking    brings    regard    controversially    alpha    prof    abuse    popular    genetically    reveals    vivo    tobias    serotonin    competitive    re    diethylamide    point    rank    unresolved    receptors    interpreted    brain    ethological    neuropsychopharmacology    potentially    interaction    protein    translates    kn    society    faced    mice    fluorescent    pyramidal    electrophysiology    inhibit    psychosis    dipl    oscillations    psychotherapy    speculative    imaging    butterfly    detriment    lysergic    virtually    controversy    metabolism    primarily    science    discussed    animals   

Project "LSD-CortLVPC" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.psyborn.com/msca-blog
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Serotonergic hallucinogens (sHG), such as lysergic acid diethylamide (LSD), rank among the most controversially discussed agents of modern neuropsychopharmacology. They are popular drugs of abuse, scientifically are used to study the pathophysiology of psychosis, can pose a threat to health, but most recently also re-gained attention as promotors of psychotherapy. The controversy at hand remains unresolved by modern science and politics, and the European Research Area is faced with the imminent challenge to come up with a strong and competitive scientific basis that is able to elucidate how these drugs work and how their working potentially translates into benefit and/or detriment to European health and society. The psychoactive effects of sHG are mediated by activation of serotonin 2A (5-HT2A) receptors within the cortex of the brain. In vivo, sHG disconnect cortical networks, desynchronise alpha oscillations and inhibit the metabolism of the cortex. In vitro, sHG primarily enhance the excitability of cortical layer V pyramidal cells (LVPCs), which is accounted for by 5-HT2A-glutamate interaction. The in vivo effects of sHG often are interpreted with regard to their in vitro effects. As there are virtually no LVPC specific investigations in living animals, however, the in vivo relevance of the postulated 5-HT2A-LVPC-glutamate triangle is highly speculative. Our project brings together Prof. Thomas Knöpfel, who has been pioneering optogenetic electrophysiology, and the 5-HT2A-hallucinogen expertise of Dipl. Psych. Tobias Buchborn. It applies advanced techniques of voltage imaging (with the voltage-sensitive fluorescent protein Butterfly 1.2 genetically targeted to LVPCs), combines them with selective neuropharmacological challenges and 5-HT2A specific ethological observations, and reveals within the brain of waking mice whether it is indeed LVPCs and their submissiveness to 5-HT2A-glutamate interaction that represent the point pivot of the cortical action of LSD.

 Publications

year authors and title journal last update
List of publications.
2018 Tobias Buchborn, Taylor Lyons, Thomas Knöpfel
Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.00017
Frontiers in Pharmacology 9 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LSD-CORTLVPC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LSD-CORTLVPC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

LYSOKIN (2020)

Architecture and regulation of PI3KC2β lipid kinase complex for nutrient signaling at the lysosome

Read More  

EcoSpy (2018)

Leveraging the potential of historical spy satellite photography for ecology and conservation

Read More