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NANOTER

Development of Ultra-Sensitive Nanotherapeutic Anticancer Agents for Boron Neutron CaptureTherapy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NANOTER project word cloud

Explore the words cloud of the NANOTER project. It provides you a very rough idea of what is the project "NANOTER" about.

closed treatments sealed size sensitive localised capture therapy selectively nanotherapeutic biologically worldwide neutron treatment performance interior healthy situation experiments innovative isotopes nanocapsules nanotubes selective cancer diseases damage ultra materials unexplored nanoter producing kill mortality ended modern irradiation charged nanoplatforms prevalence incidence overcome previously carbon interdisciplinary society delivered neutrons particles cells agents alternative tissue tumour form suitable biocompatible radiotherapy species thermal diagnosis exploits surrounding cell nct one limited

Project "NANOTER" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	170˙121 €
EC max contribution	170˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2018-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	170˙121.00

Map

Project objective

One of the major challenges in modern society is the early diagnosis and treatment of diseases. Cancer is one of the most relevant diseases worldwide because of its incidence, prevalence and mortality. Current cancer treatments do not only kill cancer cells but also healthy tissue. In order to overcome this situation, more effective and selective treatments are necessary. Neutron capture therapy (NCT) is a biologically targeted form of radiotherapy which exploits the potential of some specific isotopes to capture thermal neutrons producing charged particles suitable for the treatment of cancer. The range of the particles produced in NCT can be limited to the size of one cell. Therefore, provided that neutron capture species are selectively delivered to tumour cells, no damage will occur to the surrounding healthy tissue. Novel delivery agents suitable for NCT must be investigated that will allow a localised cancer treatment. NANOTER presents an innovative and previously unexplored approach to develop ultra-sensitive nanotherapeutic agents for NCT. Neutron capture species will be sealed in the interior of carbon nanocapsules (biocompatible closed-ended carbon nanotubes) and their behaviour against neutron irradiation experiments will be investigated and compared against other current materials for NCT. The interdisciplinary approach taken to develop the proposed research programme is expected to contribute to the development of alternative and previously unexplored nanoplatforms for NCT, enhancing the performance of current delivery agents for NCT.

Publications

List of publications.
year	authors and title	journal	last update
2018	Carla I. M. Santos, InÃªs F. A. Mariz, Sandra N. Pinto, Gil GonÃ§alves, Igor Bdikin, Paula A. A. P. Marques, Maria GraÃ§a P. M. S. Neves, JosÃ© M. G. Martinho, Ermelinda M. S. MaÃ§Ã´as Selective two-photon absorption in carbon dots: a piece of the photoluminescence emission puzzle published pages: 12505-12514, ISSN: 2040-3364, DOI: 10.1039/C8NR03365J	Nanoscale 10/26	2019-06-13
2018	Concepcion Domingo, Alejandro BorrÃ¡s-Caballero, Gil GonÃ§alves, Gregorio MarbÃ¡n, Stefania Sandoval, Susana Pinto, Paula Marques, Julio Fraile, Gerard Tobias, Ana LÃ³pez-Periago Preparation and characterization of graphene oxide aerogels: exploring the limits of supercritical CO2 fabrication methods published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201803368	Chemistry - A European Journal	2019-06-13
2018	Magdalena Kierkowicz, Elzbieta Pach, Ana SantidriÃ¡n, Stefania Sandoval, Gil GonÃ§alves, Ester TobÃas-Rossell, Martin KalbÃ¡Ä, BelÃ©n Ballesteros, Gerard Tobias Comparative study of shortening and cutting strategies of single-walled and multi-walled carbon nanotubes assessed byÂ scanning electron microscopy published pages: 922-932, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2018.06.021	Carbon 139	2019-06-13

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The information about "NANOTER" are provided by the European Opendata Portal: CORDIS opendata.