NanoSCAN SIGNED
Developing multi-modality nanomedicines for targeted annotation of oncogenic signaling pathways
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the NanoSCAN project. It provides you a very rough idea of what is the project "NanoSCAN" about.
Project "NanoSCAN" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAT ZURICH
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Project website | http://www.hollandlab.org |
| Total cost | 1˙700˙000 € |
| EC max contribution | 1˙700˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2021-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAT ZURICH | CH (Zürich) | coordinator | 1˙700˙000.00 |
Map
Project objective
Spatial and temporal changes in the underlying biochemistry of cancer control disease progression and response/resistance to treatment. Developing methods to detect changes in oncogenic signaling at an early stage is vital to further our understanding of cancer, and will advance the next generation of anti-cancer therapies. Nanomedicine is the medical application of nanotechnology to diagnose or treat disease. In light of the recent introduction of tools like Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) scanners, there is now a new opportunity to develop hybrid imaging protocols that can simultaneously take advantage of the functional and anatomic information available from PET/MRI to address changes in oncogenic signaling pathways. The work outlined in this interdisciplinary ERC Project is designed to advance new chemistry and imaging methods to measure changes in oncogenic signaling in various cancers before, during and after treatment using PET/MRI. The long-term goals are to expand the scope and utility of radiolabelled nanomedicines as dual-modality PET/MRI probes for detecting changes in oncogenic signaling in various cancers and develop efficient methods for translating new technologies to the clinic. Successful completion of this ERC Project has the potential to transform personalised clinical management of cancer patients via advanced PET/MRI detection of oncogenic signaling processes.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Thomas L. Collier, Kenneth Dahl, Nickeisha A. Stephenson, Jason P. Holland, Adam Riley, Steven H. Liang, Neil Vasdev Recent applications of a single quadrupole mass spectrometer in 11 C, 18 F and radiometal chemistry published pages: 46-55, ISSN: 0022-1139, DOI: 10.1016/j.jfluchem.2018.02.009 |
Journal of Fluorine Chemistry 210 | 2019-07-08 |
| 2017 |
Alexander Schmidtke, Tilman Läppchen, Christian Weinmann, Lorenz Bier-Schorr, Manfred Keller, Yvonne Kiefer, Jason P. Holland, Mark D. Bartholomä Gallium Complexation, Stability, and Bioconjugation of 1,4,7-Triazacyclononane Derived Chelators with Azaheterocyclic Arms published pages: 9097-9110, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.7b01129 |
Inorganic Chemistry 56/15 | 2019-07-08 |
| 2017 |
Eleni Gourni, Luigi Del Pozzo, Mark Bartholomä, Yvonne Kiefer, Philipp T. Meyer, Helmut R. Maecke, Jason P. Holland Radiochemistry and Preclinical PET Imaging of 68 Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen published pages: 153601211773701, ISSN: 1536-0121, DOI: 10.1177/1536012117737010 |
Molecular Imaging 16 | 2019-07-08 |
| 2018 |
Tilman Läppchen, Yvonne Kiefer, Jason P. Holland, Mark D. Bartholomä In vitro and in vivo evaluation of the bifunctional chelator NODIA-Me in combination with a prostate-specific membrane antigen targeting vector published pages: 45-54, ISSN: 0969-8051, DOI: 10.1016/j.nucmedbio.2018.03.002 |
Nuclear Medicine and Biology 60 | 2019-07-08 |
| 2016 |
JasonP. Holland The Role of Molecular Imaging in Personalised Healthcare published pages: 787-795, ISSN: 0009-4293, DOI: 10.2533/chimia.2016.787 |
CHIMIA International Journal for Chemistry 70/11 | 2019-07-08 |
| 2018 |
Jennifer Lamb, Jason P. Holland Advanced Methods for Radiolabeling Multimodality Nanomedicines for SPECT/MRI and PET/MRI published pages: 382-389, ISSN: 0161-5505, DOI: 10.2967/jnumed.116.187419 |
Journal of Nuclear Medicine 59/3 | 2019-07-08 |
| 2018 |
Eszter Boros, Jason P. Holland Chemical aspects of metal ion chelation in the synthesis and application antibody-based radiotracers published pages: , ISSN: 0362-4803, DOI: 10.1002/jlcr.3590 |
Journal of Labelled Compounds and Radiopharmaceuticals | 2019-07-08 |
| 2019 |
Rachael Fay, Melanie Gut, Jason P. Holland Photoradiosynthesis of 68 Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors published pages: 1814-1820, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.9b00342 |
Bioconjugate Chemistry 30/6 | 2019-09-04 |
| 2019 |
Rachael Fay, Jason P. Holland The impact of emerging bioconjugation chemistries on radiopharmaceuticals published pages: , ISSN: 0161-5505, DOI: 10.2967/jnumed.118.220806 |
Journal of Nuclear Medicine 12 | 2019-05-27 |
| 2019 |
Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland Photochemische Konjugation und Eintopfradiomarkierung von Antikörpern für Immun-PET published pages: 1946-1951, ISSN: 0044-8249, DOI: 10.1002/ange.201813287 |
Angewandte Chemie 131/7 | 2019-05-27 |
| 2018 |
Christian Weinmann, Jason P. Holland, Tilman Läppchen, Harald Scherer, Stephan Maus, Tobias Stemler, Hendrik Bohnenberger, Samer Ezziddin, Philipp Kurz, Mark D. Bartholomä Optimized synthesis and indium complex formation with the bifunctional chelator NODIA-Me published pages: 7503-7512, ISSN: 1477-0520, DOI: 10.1039/c8ob01981a |
Organic & Biomolecular Chemistry 16/40 | 2019-05-27 |
| 2018 |
Tilman Läppchen, Jason P. Holland, Yvonne Kiefer, Mark D. Bartholomä Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me published pages: , ISSN: 2365-421X, DOI: 10.1186/s41181-018-0043-2 |
EJNMMI Radiopharmacy and Chemistry 3/1 | 2019-05-27 |
| 2018 |
Jason P. Holland Chemical Kinetics of Radiolabelling Reactions published pages: 16472-16483, ISSN: 0947-6539, DOI: 10.1002/chem.201803261 |
Chemistry - A European Journal 24/62 | 2019-05-27 |
| 2019 |
Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland Frontispiece: Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201980761 |
Angewandte Chemie International Edition 58/7 | 2019-05-27 |
| 2018 |
Jason P. Holland Antibody-based radiopharmaceuticals for imaging and therapy published pages: 610-610, ISSN: 0362-4803, DOI: 10.1002/jlcr.3636 |
Journal of Labelled Compounds and Radiopharmaceuticals 61/9 | 2019-05-27 |
| 2019 |
Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET published pages: 1928-1933, ISSN: 1433-7851, DOI: 10.1002/anie.201813287 |
Angewandte Chemie International Edition 58/7 | 2019-05-27 |
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