Explore the words cloud of the DENDRITECIRCUITS project. It provides you a very rough idea of what is the project "DENDRITECIRCUITS" about.
The following table provides information about the project.
Coordinator |
UNIVERSITY COLLEGE LONDON
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://www.dendrites.org |
Total cost | 2˙495˙563 € |
EC max contribution | 2˙495˙563 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-AdG |
Funding Scheme | ERC-ADG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-07-01 to 2021-06-30 |
Take a look of project's partnership.
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1 | UNIVERSITY COLLEGE LONDON | UK (LONDON) | coordinator | 2˙495˙563.00 |
This proposal aims to address a simple question: what is the fundamental unit of computation in the brain? Answering this question is crucial not only for understanding how the brain works, but also if we are to build accurate models of brain function, which require abstraction based on identification of the essential elements for carrying out computations relevant to behaviour. In this proposal, we will build on recent work demonstrating that dendrites are highly electrically excitable to test the possibility that single dendritic branches may act as individual computational units during behaviour, challenging the classical view that the neuron is the fundamental unit of computation. We will address this question using a combination of electrophysiolgical, anatomical, imaging, molecular, and modeling approaches to probe dendritic integration in pyramidal cells and Purkinje cells in mouse cortex and cerebellum.
We will first define the computational rules for integration of synaptic input in single and multiple dendrites by examining the somatic and dendritic responses to different spatiotemporal patterns of excitatory and inhibitory inputs in brain slices. Next, we will determine how these rules are engaged by patterns of sensory stimulation in vivo, by using various strategies to map the spatiotemporal patterns of synaptic inputs onto single dendrites. To understand how physiological patterns of activity in the circuit engage these dendritic computations, we will use anatomical approaches to map the wiring diagram of synaptic inputs to individual dendrites. Finally, we will perturb the dendritic computational rules by manipulating dendritic function using molecular and optogenetic tools, in order to provide causal links between specific dendritic computations and sensory processing relevant to behaviour.
These experiments will provide us with deeper insights into how single neurons act as computing devices.
year | authors and title | journal | last update |
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2017 |
Christoph Schmidt-Hieber, Gabija Toleikyte, Laurence Aitchison, Arnd Roth, Beverley A Clark, Tiago Branco, Michael Häusser Active dendritic integration as a mechanism for robust and precise grid cell firing published pages: 1114-1121, ISSN: 1097-6256, DOI: 10.1038/nn.4582 |
Nature Neuroscience 20/8 | 2019-08-05 |
2018 |
Zihui Zhang, Lloyd E. Russell, Adam M. Packer, Oliver M. Gauld, Michael Häusser Closed-loop all-optical interrogation of neural circuits in vivo published pages: 1037-1040, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0183-z |
Nature Methods 15/12 | 2019-08-06 |
2019 |
Dimitar Kostadinov, Maxime Beau, Marta Blanco Pozo, Michael Häusser Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells published pages: 950-962, ISSN: 1097-6256, DOI: 10.1038/s41593-019-0381-8 |
Nature Neuroscience 22/6 | 2019-08-05 |
2016 |
Zachary F. Mainen, Michael Häusser, Alexandre Pouget A better way to crack the brain published pages: 159-161, ISSN: 0028-0836, DOI: 10.1038/539159a |
Nature 539/7628 | 2019-08-06 |
2017 |
Lorenza Magno, Caswell Barry, Christoph Schmidt-Hieber, Polyvios Theodotou, Michael Häusser, Nicoletta Kessaris NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory published pages: 1572-1584, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.07.053 |
Cell Reports 20/7 | 2019-08-06 |
2017 |
Nicholas A. Steinmetz, Christina Buetfering, Jerome Lecoq, Christian R. Lee, Andrew J. Peters, Elina A. K. Jacobs, Philip Coen, Douglas R. Ollerenshaw, Matthew T. Valley, Saskia E. J. de Vries, Marina Garrett, Jun Zhuang, Peter A. Groblewski, Sahar Manavi, Jesse Miles, Casey White, Eric Lee, Fiona Griffin, Joshua D. Larkin, Kate Roll, Sissy Cross, Thuyanh V. Nguyen, Rachael Larsen, Julie Pendergra Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines published pages: ENEURO.0207-17.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0207-17.2017 |
eneuro 4/5 | 2019-08-06 |
2016 |
Joshua T. Vogelstein, Brett Mensh, Michael Häusser, Nelson Spruston, Alan C. Evans, Konrad Kording, Katrin Amunts, Christoph Ebell, Jeff Muller, Martin Telefont, Sean Hill, Sandhya P. Koushika, Corrado Calì, Pedro Antonio Valdés-Sosa, Peter B. Littlewood, Christof Koch, Stephan Saalfeld, Adam Kepecs, Hanchuan Peng, Yaroslav O. Halchenko, Gregory Kiar, Mu-Ming Poo, Jean-Baptiste Poline, Michael To the Cloud! A Grassroots Proposal to Accelerate Brain Science Discovery published pages: 622-627, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.10.033 |
Neuron 92/3 | 2019-08-06 |
2017 |
James J. Jun, Nicholas A. Steinmetz, Joshua H. Siegle, Daniel J. Denman, Marius Bauza, Brian Barbarits, Albert K. Lee, Costas A. Anastassiou, Alexandru Andrei, Çağatay Aydın, Mladen Barbic, Timothy J. Blanche, Vincent Bonin, João Couto, Barundeb Dutta, Sergey L. Gratiy, Diego A. Gutnisky, Michael Häusser, Bill Karsh, Peter Ledochowitsch, Carolina Mora Lopez, Catalin Mitelut, Silke Musa, Micha Fully integrated silicon probes for high-density recording of neural activity published pages: 232-236, ISSN: 0028-0836, DOI: 10.1038/nature24636 |
Nature 551/7679 | 2019-08-06 |
2017 |
Larry F. Abbott, Dora E. Angelaki, Matteo Carandini, Anne K. Churchland, Yang Dan, Peter Dayan, Sophie Deneve, Ila Fiete, Surya Ganguli, Kenneth D. Harris, Michael Häusser, Sonja Hofer, Peter E. Latham, Zachary F. Mainen, Thomas Mrsic-Flogel, Liam Paninski, Jonathan W. Pillow, Alexandre Pouget, Karel Svoboda, Ilana B. Witten, Anthony M. Zador An International Laboratory for Systems and Computational Neuroscience published pages: 1213-1218, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.12.013 |
Neuron 96/6 | 2019-08-06 |
2016 |
Ingrid van Welie, Arnd Roth, Sara S.N. Ho, Shoji Komai, Michael Häusser Conditional Spike Transmission Mediated by Electrical Coupling Ensures Millisecond Precision-Correlated Activity among Interneurons In Vivo published pages: 810-823, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.04.013 |
Neuron 90/4 | 2019-06-07 |
2017 |
Thomas Lissek, Michelle Adams, John Adelman, Ehud Ahissar, Mohammed Akaaboune, Huda Akil, Mustafa al’Absi, Fazal Arain, Juan Carlos Arango-Lasprilla, Deniz Atasoy, Jesus Avila, Ashraf Badawi, Hilmar Bading, Abdul Mannan Baig, Jimena Baleriola, Carlos Belmonte, Ilaria Bertocchi, Heinrich Betz, Colin Blakemore, Olaf Blanke, Philipp Boehm-Sturm, Tobias Bonhoeffer, Paolo Bonifazi, Nils Brose, Patrizia Campolongo, Tansu Celikel, Cathy C. Chang, Ta-Yuan Chang, Ami Citri, Hollis T. Cline, Jesus M. Cortes, Kathleen Cullen, Kellie Dean, José M. Delgado-Garcia, Mathieu Desroches, John F. Disterhoft, John E. Dowling, Andreas Draguhn, Sherif F. El-Khamisy, Abdeljabbar El Manira, S. Ather Enam, Juan M. Encinas, Asier Erramuzpe, José A. Esteban, Isabel Fariñas, Edmond Fischer, Izumi Fukunaga, Iñigo Gabilondo, Detlev Ganten, Albert Gidon, Juan Carlos Gomez-Esteban, Paul Greengard, Valery Grinevich, Agnés Gruart, Roger Guillemin, Ahmad R. Hariri, Bassem Hassan, Michael Häusser, Yasunori Hayashi, Natasha K. Hussain, Adnan Abdul Jabbar, Mohamed Jaber, Reinhardt Jahn, Essam Mohammed Janahi, Mohamed Kabbaj, Helmut Kettenmann, Merel Kindt, Shira Knafo, Georg Köhr, Shoji Komai, Harm Krugers, Bernd Kuhn, Nouria Lakhdar Ghazal, Matthew E. Larkum, Mickey London, Beat Lutz, Carlos Matute, Luis Martinez-Millan, Mouna Maroun, James McGaugh, Ahmed A. Moustafa, Anwar Nasim, Klaus-Armin Nave, Erwin Neher, Karoly Nikolich, Tiago Outeiro, Lucy M. Palmer, Olga Penagarikano, Isabel Perez-Otano, Donald W. Pfaff, Bruno Poucet, Atta-ur Rahman, Pedro Ramos-Cabrer, Ali Rashidy-Pour, Richard J. Roberts, Serafim Rodrigues, Joshua R. Sanes, Andreas T. Schaefer, Menahem Segal, Idan Segev, Saad Shafqat, Nikhat Ahmed Siddiqui, Hermona Soreq, Eduardo Soriano-GarcÃa, Rainer Spanagel, Rolf Sprengel, Greg Stuart, Thomas C. Südhof, Jan Tønnesen, Mario Treviño, Basim M. Uthman, J. Craig Venter, Alexei Verkhratsky, Craig Weiss, Torsten N. Wiesel, Emre Yaksi, Ofer Yizhar, Larry J. Young, Paul Young, Nasser H. Zawia, José L. Zugaza, Mazahir T. Hasan Building Bridges through Science published pages: 730-735, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.09.028 |
Neuron 96/4 | 2019-06-07 |
2016 |
Anatoly Buchin, Sarah Rieubland, Michael Häusser, Boris S. Gutkin, Arnd Roth Inverse Stochastic Resonance in Cerebellar Purkinje Cells published pages: e1005000, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1005000 |
PLOS Computational Biology 12/8 | 2019-08-06 |
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