RespeCT SIGNED
Respiratory Disease Screening with Dark-Field Computed Tomography
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the RespeCT project. It provides you a very rough idea of what is the project "RespeCT" about.
Project "RespeCT" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITAET MUENCHEN
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | https://www.e17.ph.tum.de/en/home/ |
| Total cost | 2˙357˙212 € |
| EC max contribution | 2˙357˙212 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-08-01 to 2021-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITAET MUENCHEN | DE (MUENCHEN) | coordinator | 2˙357˙212.00 |
Map
Project objective
The grand goal of this proposal is to translate a recently explored and fundamentally different x-ray contrast mechanism, namely x-ray dark-field imaging, from present in-vivo small-animal proof-of-principle studies to a first clinical dark-field computed tomography (CT) prototype for future human diagnostics. Complementing this main technological development goal, we will explore the potential future clinical diagnostic application range of this technology by systematically screening multiple small-animal disease models. As one of the potentially most beneficial applications, we will particularly focus on one rapidly growing challenge in the healthcare sector, namely the early detection and screening of chronic obstructive pulmonary disease (COPD). For Europe, COPD has been estimated to affect 5-10% of adults over 40 years of age. This translates to 12-25 million individuals affected by COPD in the European Union. If dark-field CT imaging can substantially improve early diagnosis and thus prompt appropriate therapeutic treatment in these patients, this project has the potential to prolong and improve the lives of millions of Europeans. Further, the cost of COPD to society in Europe could be decreased by billions each year, if COPD – with emphysema as one of its main components – could be accurately detected, effectively treated, and stabilized at early stages of the disease. Besides COPD, we will explore the potential clinical benefit of dark-field CT for better diagnosis of pulmonary fibrosis, lung cancer, asthma, pneumothorax, acute lung injury, bronchopulmonary dysplasia, inflammation, and radiation-induced lung injury as a consequence of radiation therapy after lung cancer. The ambition to deliver more than just an academic proof-of-principle development, but a clinically usable new imaging device for a broad medical community is underlined by a firm commitment of an industrial partner (Philips) to support this project, should the proposal receive funding.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Eva Braig, Jessica Böhm, Martin Dierolf, Christoph Jud, Benedikt Günther, Korbinian Mechlem, Sebastian Allner, Thorsten Sellerer, Klaus Achterhold, Bernhard Gleich, Peter Noël, Daniela Pfeiffer, Ernst Rummeny, Julia Herzen, Franz Pfeiffer Direct quantitative material decomposition employing grating-based X-ray phase-contrast CT published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34809-6 |
Scientific Reports 8/1 | 2019-08-05 |
| 2019 |
R. Gradl, K. S. Morgan, M. Dierolf, C. Jud, L. Hehn, B. Gunther, W. Moller, D. Kutschke, L. Yang, T. Stoeger, D. Pfeiffer, B. Gleich, K. Achterhold, O. Schmid, F. Pfeiffer Dynamic published pages: 649-656, ISSN: 0278-0062, DOI: 10.1109/tmi.2018.2868999 |
IEEE Transactions on Medical Imaging 38/2 | 2019-08-05 |
| 2018 |
Eva-Maria Braig, Lorenz Birnbacher, Florian Schaff, Lukas Gromann, Alexander Fingerle, Julia Herzen, Ernst Rummeny, Peter Noël, Franz Pfeiffer, Daniela Muenzel Simultaneous wood and metal particle detection on dark-field radiography published pages: , ISSN: 2509-9280, DOI: 10.1186/s41747-017-0034-1 |
European Radiology Experimental 2/1 | 2019-08-05 |
| 2017 |
Mathias Marschner, Lorenz Birnbacher, Marian Willner, Michael Chabior, Julia Herzen, Peter B. Noël, Franz Pfeiffer Revising the lower statistical limit of x-ray grating-based phase-contrast computed tomography published pages: e0184217, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0184217 |
PLOS ONE 12/9 | 2019-08-05 |
| 2018 |
Manuel Viermetz, Lorenz Birnbacher, Marian Willner, Klaus Achterhold, Franz Pfeiffer, Julia Herzen High resolution laboratory grating-based X-ray phase-contrast CT published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33997-5 |
Scientific Reports 8/1 | 2019-08-05 |
| 2018 |
Matthias Wieczorek, Florian Schaff, Christoph Jud, Daniela Pfeiffer, Franz Pfeiffer, Tobias Lasser Brain Connectivity Exposed by Anisotropic X-ray Dark-field Tomography published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32023-y |
Scientific Reports 8/1 | 2019-08-05 |
| 2018 |
Katharina Hellbach, Felix G. Meinel, Thomas M. Conlon, Konstantin Willer, Andre Yaroshenko, Astrid Velroyen, Margarita Braunagel, Sigrid Auweter, Maximilian F. Reiser, Oliver Eickelberg, Franz Pfeiffer, Ali Ö. Yildirim X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-20193-8 |
Scientific Reports 8/1 | 2019-08-05 |
| 2018 |
A. Gustschin, T. Neuwirth, A. Backs, M. Schulz, F. Pfeiffer Fabrication of gadolinium particle-based absorption gratings for neutron grating interferometry published pages: 103702, ISSN: 0034-6748, DOI: 10.1063/1.5047055 |
Review of Scientific Instruments 89/10 | 2019-08-05 |
| 2017 |
Lukas B. Gromann, Fabio De Marco, Konstantin Willer, Peter B. Noël, Kai Scherer, Bernhard Renger, Bernhard Gleich, Klaus Achterhold, Alexander A. Fingerle, Daniela Muenzel, Sigrid Auweter, Katharina Hellbach, Maximilian Reiser, Andrea Baehr, Michaela Dmochewitz, Tobias J. Schroeter, Frieder J. Koch, Pascal Meyer, Danays Kunka, Juergen Mohr, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendr In-vivo X-ray Dark-Field Chest Radiography of a Pig published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05101-w |
Scientific Reports 7/1 | 2019-08-05 |
| 2017 |
Christoph Jud, Eva Braig, Martin Dierolf, Elena Eggl, Benedikt Günther, Klaus Achterhold, Bernhard Gleich, Ernst Rummeny, Peter Noël, Franz Pfeiffer, Daniela Muenzel Trabecular bone anisotropy imaging with a compact laser-undulator synchrotron x-ray source published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14830-x |
Scientific Reports 7/1 | 2019-08-05 |
| 2017 |
Maximilian von Teuffenbach, Thomas Koehler, Andreas Fehringer, Manuel Viermetz, Bernhard Brendel, Julia Herzen, Roland Proksa, Ernst J. Rummeny, Franz Pfeiffer, Peter B. Noël Grating-based phase-contrast and dark-field computed tomography: a single-shot method published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-06729-4 |
Scientific Reports 7/1 | 2019-08-05 |
| 2019 |
Julia Herzen, Dimitrios C. Karampinos, Peter Foehr, Lorenz Birnbacher, Manuel Viermetz, Rainer Burgkart, Thomas Baum, Fabian Lohoefer, Moritz Wildgruber, Franz Schilling, Marian Willner, Mathias Marschner, Peter B. Noël, Ernst J. Rummeny, Franz Pfeiffer, Pia M. Jungmann 3D grating-based X-ray phase-contrast computed tomography for high-resolution quantitative assessment of cartilage: An experimental feasibility study with 3T MRI, 7T MRI and biomechanical correlation published pages: e0212106, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0212106 |
PLOS ONE 14/2 | 2019-08-05 |
| 2018 |
Katharina Hellbach, Andrea Baehr, Fabio De Marco, Konstantin Willer, Lukas B. Gromann, Julia Herzen, Michaela Dmochewitz, Sigrid Auweter, Alexander A. Fingerle, Peter B. Noël, Ernst J. Rummeny, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendrik van der Heijden, Nataly Wieberneit, Roland Proksa, Thomas Koehler, Karsten Rindt, Tobias J. Schroeter, Juergen Mohr, Fabian Bamberg, Birgit Ertl-W Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-20985-y |
Scientific Reports 8/1 | 2019-08-05 |
| 2018 |
Konstantin Willer, Alexander A. Fingerle, Lukas B. Gromann, Fabio De Marco, Julia Herzen, Klaus Achterhold, Bernhard Gleich, Daniela Muenzel, Kai Scherer, Martin Renz, Bernhard Renger, Felix Kopp, Fabian Kriner, Florian Fischer, Christian Braun, Sigrid Auweter, Katharina Hellbach, Maximilian F. Reiser, Tobias Schroeter, Juergen Mohr, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendrik van d X-ray dark-field imaging of the human lung—A feasibility study on a deceased body published pages: e0204565, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204565 |
PLOS ONE 13/9 | 2019-08-05 |
| 2018 |
Susan Notohamiprodjo, Nicole Webber, Lorenz Birnbacher, Marian Willner, Manuel Viermetz, Julia Herzen, Mathias Marschner, Doris Mayr, Harald Bartsch, Tobias Saam, Sigrid Auweter, Franz Pfeiffer, Maximilian F. Reiser, Holger Hetterich Qualitative and Quantitative Evaluation of Structural Myocardial Alterations by Grating-Based Phase-Contrast Computed Tomography published pages: 26-34, ISSN: 0020-9996, DOI: 10.1097/rli.0000000000000408 |
Investigative Radiology 53/1 | 2019-08-05 |
| 2018 |
Lorenz Birnbacher, Manuel Viermetz, Wolfgang Noichl, Sebastian Allner, Andreas Fehringer, Mathias Marschner, Maximilian von Teuffenbach, Marian Willner, Klaus Achterhold, Peter B. Noël, Thomas Koehler, Julia Herzen, Franz Pfeiffer Tilted grating phase-contrast computed tomography using statistical iterative reconstruction published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25075-7 |
Scientific Reports 8/1 | 2019-08-05 |
| 2018 |
Lorenz Birnbacher, Stefanie Maurer, Katharina Scheidt, Julia Herzen, Franz Pfeiffer, Tobias Fromme Electron Density of Adipose Tissues Determined by Phase-Contrast Computed Tomography Provides a Measure for Mitochondrial Density and Fat Content published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00707 |
Frontiers in Physiology 9 | 2019-08-05 |
| 2018 |
Elena Eggl, Susanne Grandl, Anikό Sztrόkay-Gaul, Martin Dierolf, Christoph Jud, Lisa Heck, Karin Burger, Benedikt Günther, Klaus Achterhold, Doris Mayr, Jan J. Wilkens, Sigrid D. Auweter, Bernhard Gleich, Karin Hellerhoff, Maximilian F. Reiser, Franz Pfeiffer, Julia Herzen Dose-compatible grating-based phase-contrast mammography on mastectomy specimens using a compact synchrotron source published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33628-z |
Scientific Reports 8/1 | 2019-08-05 |
| 2019 |
Karin Hellerhoff, Lorenz Birnbacher, Anikó Sztrókay-Gaul, Susanne Grandl, Sigrid Auweter, Marian Willner, Mathias Marschner, Doris Mayr, Maximilian F. Reiser, Franz Pfeiffer, Julia Herzen Assessment of intraductal carcinoma in situ (DCIS) using grating-based X-ray phase-contrast CT at conventional X-ray sources: An experimental ex-vivo study published pages: e0210291, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0210291 |
PLOS ONE 14/1 | 2019-08-05 |
| 2019 |
Nikolai Gustschin, Alex Gustschin, Pascal Meyer, Manuel Viermetz, Philipp Riederer, Julia Herzen, Jürgen Mohr, Franz Pfeifferark Quality and parameter control of X-ray absorption gratings by angular X-ray transmission published pages: 15943, ISSN: 1094-4087, DOI: 10.1364/oe.27.015943 |
Optics Express 27/11 | 2019-08-05 |
| 2017 |
Margarita Braunagel, Lorenz Birnbacher, Marian Willner, Mathias Marschner, Fabio De Marco, Manuel Viermetz, Susan Notohamiprodjo, Katharina Hellbach, Sigrid Auweter, Vera Link, Christine Woischke, Maximilian F. Reiser, Franz Pfeiffer, Mike Notohamiprodjo, Julia Herzen Qualitative and Quantitative Imaging Evaluation of Renal Cell Carcinoma Subtypes with Grating-based X-ray Phase-contrast CT published pages: , ISSN: 2045-2322, DOI: 10.1038/srep45400 |
Scientific Reports 7/1 | 2019-08-05 |
| 2018 |
Y. Sharma, S. Bachche, M. Kageyama, M. Kuribayashi, F. Pfeiffer, T. Lasser, A. Momose Trochoidal X-ray Vector Radiography: Directional dark-field without grating stepping published pages: 111902, ISSN: 0003-6951, DOI: 10.1063/1.5020361 |
Applied Physics Letters 112/11 | 2019-08-05 |
| 2019 |
Fabio De Marco, Konstantin Willer, Lukas B. Gromann, Jana Andrejewski, Katharina Hellbach, Andrea Bähr, Michaela Dmochewitz, Thomas Koehler, Hanns-Ingo Maack, Franz Pfeiffer, Julia Herzen Contrast-to-noise ratios and thickness-normalized, ventilation-dependent signal levels in dark-field and conventional in vivo thorax radiographs of two pigs published pages: e0217858, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0217858 |
PLOS ONE 14/6 | 2019-08-05 |
| 2018 |
Fabio De Marco, Mathias Marschner, Lorenz Birnbacher, Peter Noël, Julia Herzen, Franz Pfeiffer Analysis and correction of bias induced by phase stepping jitter in grating-based X-ray phase-contrast imaging published pages: 12707, ISSN: 1094-4087, DOI: 10.1364/oe.26.012707 |
Optics Express 26/10 | 2019-08-05 |
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