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GUPPYSEX SIGNED

Evolutionary genetics of guppy sex chromosomes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GUPPYSEX project word cloud

Explore the words cloud of the GUPPYSEX project. It provides you a very rough idea of what is the project "GUPPYSEX" about.

differing gaps population sex hypothesis region tests coloration expression sa rates conspicuous markers map documented fundamental evolutionary frequencies closer complicated expertise attractive fill male group individuals plausible populations natural poecilia chromosomes molecular reticulata dna autosomal carries gene behavioural fish chromosome direct linked linkage genetics regimes estimate lacks age pseudo emerge benefit polymorphisms ideal sequence collaborators divergence ecological predictions arise fitness guppy team genes first sexes multiple reduce guppies lower sexual predicted recombination complement genetic modifers antagonism versus compensating assembled gain evolution strength unless females mapped xx males allele predation thought phenotypes predators suppressed par conflict mutations

Project "GUPPYSEX" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙550˙235 €
EC max contribution	1˙550˙235 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-08-01 to 2021-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	coordinator	930˙607.00
2	THE UNIVERSITY OF EXETER THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EXETER)	participant	619˙627.00

Map

Project objective

I propose an integrated programme of molecular genetic studies to fill fundamental gaps in our knowledge of sex chromosome evolution. Specifically, I will use a fish, the guppy (Poecilia reticulata), to test the sexual antagonism (SA) hypothesis of sex chromosome evolution, which is plausible, but lacks direct evidence. SA mutations (that benefit one sex but lower fitness of the other) are proposed to arise in a partially sex-linked (pseudo-autosomal region, or PAR) gene, and establish polymorphisms. To reduce the conflict between the sexes, suppressed recombination between X and Y chromosomes then evolves (unless sex-specific expression evolves first). The guppy is ideal for studying this hypothesis because SA polymorphisms are well documented: male coloration phenotypes make males attractive to females, but also make them conspicuous to predators (while females gain no compensating benefit). Moreover, guppies have a recombination-suppressed sex-linked region that carries multiple coloration genes, yet is thought to have evolved recently. However, no non-Y-linked coloration factor has yet been mapped, and the genetics is complicated by modifers making some XX individuals male, and by male-specific expression of some phenotypes. I will map coloration genes and identify PAR genes using DNA-based markers to take account of these problems. I will test for the predicted lower coloration allele frequencies in natural populations with high versus low predation rates, and do population genetic analyses to test for closer linkage under high predation. I will also use X-Y sequence divergence to estimate the age of the guppy sex chromosome. The project tests predictions that emerge from well-documented differing selection regimes in natural guppy populations. I have therefore assembled a team of collaborators experienced with guppies who can provide behavioural and ecological genetic expertise to complement the strength of my own group in molecular evolutionary genetics.

Publications

List of publications.
year	authors and title	journal	last update
2018	Tim Connallon, Colin Olito, Ludovic Dutoit, Homa Papoli, Filip Ruzicka, Lengxob Yong Local adaptation and the evolution of inversions on sex chromosomes and autosomes published pages: 20170423, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0423	Philosophical Transactions of the Royal Society B: Biological Sciences 373/1757	2020-01-24
2018	Deborah Charlesworth The Guppy Sex Chromosome System and the Sexually Antagonistic Polymorphism Hypothesis for Y Chromosome Recombination Suppression published pages: 264, ISSN: 2073-4425, DOI: 10.3390/genes9050264	Genes 9/5	2020-01-24

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