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REDOXDRUGS SIGNED

Discovery and commercialisation of novel compounds targeting redox proteins

Total Cost €

EC-Contrib. €

Partnership

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REDOXDRUGS project word cloud

Explore the words cloud of the REDOXDRUGS project. It provides you a very rough idea of what is the project "REDOXDRUGS" about.

family efficient compounds validation months throughput molecules molecular disease alter agents virtual proteins peroxiredoxin screen subsequently cambridge therapeutics facility cycle members hit efficacy rapid cancer compound clinical function idea chemicals produces supercomputer university therapeutic biological prototyping cardiovascular proof screening diseases ranging prdx4 chemical characterised untapped assays metabolic computational hits

Project "REDOXDRUGS" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	149˙996 €
EC max contribution	149˙996 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-PoC
Funding Scheme	ERC-POC
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2018-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	149˙996.00

Map

Project objective

The Peroxiredoxin proteins represent a currently untapped molecular therapeutic target. We recently characterised a range of novel chemical compounds that could alter the function of one of the peroxiredoxin family members, peroxiredoxin 4 (PRDX4). The approach involved high-throughput computational “virtual” compound screening involving our supercomputer facility at the University of Cambridge. Given our success in finding chemicals that could affect the function of these proteins, we would now like to screen and provide proof-of-principle evidence of the efficacy of novel compounds for further development as therapeutic agents.

This process has been very rapid for prototyping novel molecules, from idea to hit compound validation in biological assays in less than 6 months. This rapid development cycle is highly cost-efficient and produces a range of chemical “hits” that could subsequently be taken forward as “lead” compounds for pre-clinical and clinical studies in the future, as novel therapeutics for a range of diseases ranging from cardiovascular and metabolic disease to cancer.

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The information about "REDOXDRUGS" are provided by the European Opendata Portal: CORDIS opendata.