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VERDI SIGNED
polyValent mEsopoRous nanosystem for bone DIseases
Total Cost €
0EC-Contrib. €
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0VERDI project word cloud
Explore the words cloud of the VERDI project. It provides you a very rough idea of what is the project "VERDI" about.
difficulty
heal
nanosystem
cancer
additionally
tackled
thereby
toolbox
therapy
solutions
biocompatibility
versatile
nanoplatform
finding
efficacy
risks
diseases
combination
contingency
edge
blocks
asymmetrical
library
vivo
cutting
decades
capacities
strategy
robustness
elaborated
slight
capacity
drug
infection
expertise
therapeutic
transition
bedside
mesoporous
producing
verdi
assembled
industrial
engineering
treatment
guarantees
multifunctional
designed
clinical
nanomedicine
group
disease
frequently
novelty
loading
revolution
tackle
relevance
plan
nanoparticles
bench
humankind
complexity
silica
peptide
risk
bone
depending
variations
nanomedicines
pathologies
osteoporosis
designing
scalable
nps
rational
building
successful
surface
either
modifying
single
completely
customizing
basis
modified
modification
Project "VERDI" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSIDAD COMPLUTENSE DE MADRID
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | http://www.ucm.es/valletregigroup/erc |
| Total cost | 2˙500˙000 € |
| EC max contribution | 2˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2021-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSIDAD COMPLUTENSE DE MADRID | ES (MADRID) | coordinator | 2˙500˙000.00 |
Map
Project objective
Finding simple solutions to complex problems has been a challenge for humankind for decades. VERDI aims at designing a multifunctional nanosystem to heal complex bone diseases. This is an engineering challenge that will be tackled through the use of building blocks designed on the basis of cutting-edge technology. These building blocks will be assembled into a versatile multifunctional nanosystem that can be adapted through slight variations for the treatment of three diseases of clinical relevance: bone infection, bone cancer and osteoporosis. The novelty of this proposal is the design of a nanosystem that may address several diseases using a unique, versatile and scalable strategy. Mesoporous silica nanoparticles are selected as the main component of the nanoplatform because of their biocompatibility, robustness, loading capacity and versatile surface modification. The nanosystem will be modified by rational selection of building blocks, with targeting and/or therapeutic abilities, to tackle either one or a combination of pathologies. These features will enable us to deliver a library of nanomedicines using a toolbox of building blocks, customizing a specific nanosystem depending on the disease to be treated. The risks associated to VERDI are numerous, such as the great complexity of producing completely asymmetrical nanoparticles (NPs), the risk that modifying a drug or therapeutic peptide will affect its therapeutic efficacy, and the difficulty of achieving effective in vivo bone targeted NPs. A contingency plan for each risk has been elaborated. The expertise and capacities of my research group guarantees successful results, which we expect to lead to a revolution in the therapy of bone cancer, bone infection and osteoporosis. Additionally, the application of a single technology for the treatment of three different but frequently associated diseases will favour industrial scale-up process, thereby promoting the transition of nanomedicine from bench to bedside.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Juan L. Paris, Gonzalo Villaverde, Sergio Gómez-Graña, MarÃa Vallet-Regà Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy published pages: 459-468, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.11.004 |
Acta Biomaterialia 101 | 2020-03-13 |
| 2020 |
L. Casarrubios, N. Gómez-Cerezo, S. Sánchez-Salcedo, M.J. Feito, M.C. Serrano, M. Saiz-Pardo, L. Ortega, D. de Pablo, I. DÃaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regà Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep published pages: 544-553, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.10.033 |
Acta Biomaterialia 101 | 2020-03-13 |
| 2020 |
Miguel Gisbert-Garzarán, Miguel Manzano, MarÃa Vallet-Regà Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis published pages: 83, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics12010083 |
Pharmaceutics 12/1 | 2020-03-13 |
| 2020 |
Juan L. Paris, MarÃa Vallet-Regà Ultrasound-Activated Nanomaterials for Therapeutics published pages: 220-229, ISSN: 0009-2673, DOI: 10.1246/bcsj.20190346 |
Bulletin of the Chemical Society of Japan 93/2 | 2020-03-13 |
| 2020 |
Daniel Arcos, MarÃa Vallet-Regà Substituted hydroxyapatite coatings of bone implants published pages: 1781-1800, ISSN: 2050-7518, DOI: 10.1039/c9tb02710f |
Journal of Materials Chemistry B 8/9 | 2020-03-13 |
| 2020 |
M. Natividad Gómez-Cerezo, Daniel Lozano, Daniel Arcos, MarÃa Vallet-RegÃ, Cedryck Vaquette The effect of biomimetic mineralization of 3D-printed mesoporous bioglass scaffolds on physical properties and in vitro osteogenicity published pages: 110572, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.110572 |
Materials Science and Engineering: C 109 | 2020-03-13 |
| 2020 |
Carlotta Pontremoli, Isabel Izquierdo-Barba, Giorgia Montalbano, MarÃa Vallet-RegÃ, Chiara Vitale-Brovarone, Sonia Fiorilli Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration published pages: 92-103, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2019.12.047 |
Journal of Colloid and Interface Science 563 | 2020-03-13 |
| 2019 |
MarÃa Vallet-RegÃ, Blanca González, Isabel Izquierdo-Barba Nanomaterials as Promising Alternative in the Infection Treatment published pages: 3806, ISSN: 1422-0067, DOI: 10.3390/ijms20153806 |
International Journal of Molecular Sciences 20/15 | 2019-10-17 |
| 2019 |
Miguel Manzano, MarÃa Vallet Regà Mesoporous Silica Nanoparticles for Drug Delivery. published pages: 1902634, ISSN: 1616-301X, DOI: 10.1002/adfm.201902634 |
Advanced Functional Materials | 2019-10-17 |
| 2019 |
Juan L. Paris, Alejandro Baeza, MarÃa Vallet-Regà Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics published pages: 1095-1112, ISSN: 1742-5247, DOI: 10.1080/17425247.2019.1662786 |
Expert Opinion on Drug Delivery 16/10 | 2019-10-17 |
| 2019 |
Rafael Alvarez , Sandra Muñoz-Piña, MarÃa U. González, Isabel Izquierdo-Barba, Iván Fernández-MartÃnez, Victor Rico, Daniel Arcos, Aurelio GarcÃa-Valenzuela, Alberto Palmero, MarÃa Vallet-Regi, AgustÃn R. , González-Elipe, José M. GarcÃa-MartÃn Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors. published pages: 1217, ISSN: 2079-4991, DOI: 10.3390/nano9091217 |
Nanomaterials | 2019-10-17 |
| 2019 |
E. Varini, S. Sánchez-Salcedo, G. Malavasi, G. Lusvardi, M. Vallet-RegÃ, A.J. Salinas Cerium (III) and (IV) containing mesoporous glasses/alginate beads for bone regeneration: Bioactivity, biocompatibility and reactive oxygen species activity published pages: 109971, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.109971 |
Materials Science and Engineering: C 105 | 2019-09-09 |
| 2019 |
Patricia Mora-Raimundo, Daniel Lozano, Miguel Manzano, MarÃa Vallet-Regà Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment published pages: 5451-5464, ISSN: 1936-0851, DOI: 10.1021/acsnano.9b00241 |
ACS Nano 13/5 | 2019-08-30 |
| 2019 |
Giulia Rossella Delpiano, Maria F. Casula, Marco Piludu, Riccardo Corpino, Pier Carlo Ricci, MarÃa Vallet-RegÃ, Enrico Sanjust, Maura Monduzzi, Andrea Salis Assembly of Multicomponent Nano-Bioconjugates Composed of Mesoporous Silica Nanoparticles, Proteins, and Gold Nanoparticles published pages: 11044-11052, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b01240 |
ACS Omega 4/6 | 2019-08-30 |
| 2019 |
N. Gómez-Cerezo, L. Casarrubios, M. Saiz-Pardo, L. Ortega, D. de Pablo, I. DÃaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regà Mesoporous bioactive glass/É›-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep published pages: 393-402, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.04.019 |
Acta Biomaterialia 90 | 2019-08-30 |
| 2019 |
Marina MartÃnez-Carmona, Isabel Izquierdo-Barba, Montserrat Colilla, MarÃa Vallet-Regà Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.07.001 |
Acta Biomaterialia | 2019-08-30 |
| 2019 |
Nadia Garino, Pasquale Sanvitale, Bianca Dumontel, Marco Laurenti, Montserrat Colilla, Isabel Izquierdo-Barba, Valentina Cauda, Maria Vallet-Regì Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent published pages: 11312-11321, ISSN: 2046-2069, DOI: 10.1039/c8ra10236h |
RSC Advances 9/20 | 2019-08-30 |
| 2017 |
M. Gisbert-Garzaran, D. Lozano, M. Vallet-RegÃ, M. Manzano Self-immolative polymers as novel pH-responsive gate keepers for drug delivery published pages: 132-136, ISSN: 2046-2069, DOI: 10.1039/c6ra26771h |
RSC Advances 7/1 | 2019-07-25 |
| 2018 |
Alejandro Baeza, MarÃa Vallet-Regà Nanomotors for Nucleic Acid, Proteins, Pollutants and Cells Detection published pages: 1579, ISSN: 1422-0067, DOI: 10.3390/ijms19061579 |
International Journal of Molecular Sciences 19/6 | 2019-07-25 |
| 2018 |
Sandra Sanchez-Salcedo, Maria Vallet-RegÃ, Sophia Allaf Shahin, Carlotta A. Glackin, Jeffrey I. Zink Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy published pages: 114-124, ISSN: 1385-8947, DOI: 10.1016/j.cej.2017.12.116 |
Chemical Engineering Journal 340 | 2019-07-25 |
| 2017 |
Marta Maycas, MarÃa Teresa Portolés, MarÃa Concepción Matesanz, Irene BuendÃa, Javier Linares, MarÃa José Feito, Daniel Arcos, MarÃa Vallet-RegÃ, Lilian I. Plotkin, Pedro Esbrit, Arancha R. Gortázar High glucose alters the secretome of mechanically stimulated osteocyte-like cells affecting osteoclast precursor recruitment and differentiation published pages: 3611-3621, ISSN: 0021-9541, DOI: 10.1002/jcp.25829 |
Journal of Cellular Physiology 232/12 | 2019-07-25 |
| 2018 |
Mónica Cicuéndez, Joana Flores, Helena Oliveira, M. Teresa Portolés, MarÃa Vallet-RegÃ, Mercedes Vila, Iola F. Duarte Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia published pages: 340-348, ISSN: 0928-4931, DOI: 10.1016/j.msec.2018.05.057 |
Materials Science and Engineering: C 91 | 2019-07-25 |
| 2018 |
Mónica Cicuéndez, Juan C. Doadrio, Ana Hernández, M. Teresa Portolés, Isabel Izquierdo-Barba, MarÃa Vallet-Regà Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection published pages: 450-461, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.11.009 |
Acta Biomaterialia 65 | 2019-07-25 |
| 2017 |
A. Baeza, R. R. Castillo, A. Torres-Pardo, J. M. González-Calbet, M. Vallet-Regà Electron microscopy for inorganic-type drug delivery nanocarriers for antitumoral applications: what does it reveal? published pages: 2714-2725, ISSN: 2050-7518, DOI: 10.1039/c6tb03062a |
Journal of Materials Chemistry B 5/15 | 2019-07-25 |
| 2018 |
Rafael R. Castillo, David Henrández-Escobar, Sergio Gómez-Graña, Maria Vallet-Regi Reversible nanogate system for Mesoporous Silica Nanoparticles based on Diels-Alder adducts. published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201706100 |
Chemistry - A European Journal | 2019-07-25 |
| 2017 |
Rafael R. Castillo, Alejandro Baeza, MarÃa Vallet-Regà Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors published pages: 353-377, ISSN: 2047-4830, DOI: 10.1039/c6bm00872k |
Biomaterials Science 5/3 | 2019-07-25 |
| 2018 |
Eduardo Guisasola, Laura AsÃn, Lilianne Beola, Jesús M. de la Fuente, Alejandro Baeza, MarÃa Vallet-Regà Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers published pages: , ISSN: 1944-8244, DOI: 10.1021/acsami.8b02398 |
ACS Applied Materials & Interfaces | 2019-07-25 |
| 2017 |
MarÃa RocÃo Villegas, Alejandro Baeza, Achraf Noureddine, Paul N. Durfee, Kimberly S. Butler, Jacob Ongudi Agola, C. Jeffrey Brinker, MarÃa Vallet-Regà Multifunctional Protocells for Enhanced Penetration in 3D Extracellular Tumoral Matrices published pages: 112-120, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.7b03128 |
Chemistry of Materials 30/1 | 2019-07-25 |
| 2017 |
M. MartÃnez-Carmona, D. Lozano, A. Baeza, M. Colilla, M. Vallet-Regà A novel visible light responsive nanosystem for cancer treatment published pages: 15967-15973, ISSN: 2040-3364, DOI: 10.1039/c7nr05050j |
Nanoscale 9/41 | 2019-07-25 |
| 2017 |
Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano, MarÃa Vallet-Regà Tuning mesoporous silica dissolution in physiological environments: a review published pages: 8761-8771, ISSN: 0022-2461, DOI: 10.1007/s10853-017-0787-1 |
Journal of Materials Science 52/15 | 2019-07-25 |
| 2018 |
Juan L. Paris, Miguel Manzano, M. Victoria Cabañas, MarÃa Vallet-Regà Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells published pages: , ISSN: 2040-3364, DOI: 10.1039/C8NR00693H |
Nanoscale | 2019-07-25 |
| 2018 |
Miguel Manzano, MarÃa Vallet-Regà Mesoporous silica nanoparticles in nanomedicine applications published pages: 65, ISSN: 0957-4530, DOI: 10.1007/s10856-018-6069-x |
Journal of Materials Science: Materials in Medicine 29/5 | 2019-07-25 |
| 2018 |
M. Gisbert-Garzarán, M. Manzano, M. Vallet-Regà Self-immolative chemistry in nanomedicine published pages: 24-31, ISSN: 1385-8947, DOI: 10.1016/j.cej.2017.12.098 |
Chemical Engineering Journal 340 | 2019-07-25 |
| 2016 |
Rafael R. Castillo, Montserrat Colilla, MarÃa Vallet-Regà Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer published pages: 229-243, ISSN: 1742-5247, DOI: 10.1080/17425247.2016.1211637 |
Expert Opinion on Drug Delivery 14/2 | 2019-07-25 |
| 2018 |
Sandra Sanchez-Salcedo, Gianluca Malavasi, Antonio Salinas, Gigliola Lusvardi, Luca Rigamonti, Ledi Menabue, Maria Vallet-Regi Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III) published pages: 367, ISSN: 1996-1944, DOI: 10.3390/ma11030367 |
Materials 11/3 | 2019-07-25 |
| 2018 |
Rebeca Pérez, Sandra Sanchez-Salcedo, Daniel Lozano, Clara Heras, Pedro Esbrit, MarÃa Vallet-RegÃ, Antonio Salinas Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin published pages: 592, ISSN: 2079-4991, DOI: 10.3390/nano8080592 |
Nanomaterials 8/8 | 2019-07-25 |
| 2018 |
Juan L. Paris, Christophoros Mannaris, M. Victoria Cabañas, Robert Carlisle, Miguel Manzano, MarÃa Vallet-RegÃ, Constantin C. Coussios Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery published pages: 2-8, ISSN: 1385-8947, DOI: 10.1016/j.cej.2017.12.051 |
Chemical Engineering Journal 340 | 2019-07-25 |
| 2017 |
Victoria López, Maria RocÃo Villegas, Verónica RodrÃguez, Gonzalo Villaverde, Daniel Lozano, Alejandro Baeza, MarÃa Vallet-Regà Janus Mesoporous Silica Nanoparticles for Dual Targeting of Tumor Cells and Mitochondria published pages: 26697-26706, ISSN: 1944-8244, DOI: 10.1021/acsami.7b06906 |
ACS Applied Materials & Interfaces 9/32 | 2019-07-25 |
| 2017 |
Alejandro Baeza, Daniel Ruiz-Molina, MarÃa Vallet-Regà Recent advances in porous nanoparticles for drug delivery in antitumoral applications: inorganic nanoparticles and nanoscale metal-organic frameworks published pages: 783-796, ISSN: 1742-5247, DOI: 10.1080/17425247.2016.1229298 |
Expert Opinion on Drug Delivery 14/6 | 2019-07-25 |
| 2018 |
Blanca González, Montserrat Colilla, Jaime DÃez, Daniel Pedraza, Marta Guembe, Isabel Izquierdo-Barba, MarÃa Vallet-Regà Mesoporous silica nanoparticles decorated with polycationic dendrimers for infection treatment published pages: 261-271, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.12.041 |
Acta Biomaterialia 68 | 2019-07-25 |
| 2017 |
MIGUEL MANZANO GARCIA, Khalid S. Mohammad, Theresa A. Guise, Maria Vallet-Regi Mechanisms of Muscle Weakness Associated with Bone Metastases published pages: 1-5, ISSN: 2377-0902, DOI: 10.15436/2377-0902.17.1188 |
International Journal of Cancer and Oncology 4/2 | 2019-07-25 |
| 2018 |
N. Gómez-Cerezo, L. Casarrubios, I. Morales, M.J. Feito, M. Vallet-RegÃ, D. Arcos, M.T. Portolés Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages published pages: 309-320, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2018.05.099 |
Journal of Colloid and Interface Science 528 | 2019-07-25 |
| 2018 |
M. RocÃo Villegas, Alejandro Baeza, Alicia Usategui, Pablo L Ortiz-Romero, José L. Pablos, MarÃa Vallet-Regà Collagenase nanocapsules: An approach to fibrosis treatment published pages: 430-438, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.05.007 |
Acta Biomaterialia 74 | 2019-07-25 |
| 2018 |
Eduardo Guisasola, Alejandro Baeza, Laura AsÃn, Jesús M. de la Fuente, MarÃa Vallet-Regà Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles published pages: 1800007, ISSN: 2366-9608, DOI: 10.1002/smtd.201800007 |
Small Methods | 2019-07-25 |
| 2017 |
Juan L. Paris, Paz de la Torre, M. Victoria Cabañas, Miguel Manzano, Montserrat Grau, Ana I. Flores, MarÃa Vallet-Regà Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy published pages: 5528-5537, ISSN: 2040-3364, DOI: 10.1039/c7nr01070b |
Nanoscale 9/17 | 2019-07-25 |
| 2018 |
Valentina Nairi, Silvia Magnolia, Marco Piludu, Mariella Nieddu, Cristian Antonio Caria, Valeria Sogos, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization published pages: , ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2018.02.019 |
Colloids and Surfaces B: Biointerfaces | 2019-07-25 |
| 2018 |
MarÃa Vallet-RegÃ, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights published pages: 47, ISSN: 1420-3049, DOI: 10.3390/molecules23010047 |
Molecules 23/1 | 2019-07-25 |
| 2017 |
Gonzalo Villaverde, Valentina Nairi, Alejandro Baeza, MarÃa Vallet-Regà Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment published pages: 7174-7179, ISSN: 0947-6539, DOI: 10.1002/chem.201605947 |
Chemistry - A European Journal 23/30 | 2019-07-25 |
| 2017 |
Miguel Gisbert-Garzarán, Miguel Manzano, MarÃa Vallet-Regà pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery published pages: 3, ISSN: 2306-5354, DOI: 10.3390/bioengineering4010003 |
Bioengineering 4/4 | 2019-07-25 |
| 2018 |
Valentina Nairi, Sara Medda, Marco Piludu, Maria Francesca Casula, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis Interactions between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers published pages: 42-50, ISSN: 1385-8947, DOI: 10.1016/j.cej.2018.01.011 |
Chemical Engineering Journal 340 | 2019-07-25 |
| 2017 |
Lorena Polo, Natividad Gómez-Cerezo, Elena Aznar, José-Luis Vivancos, Félix Sancenón, Daniel Arcos, MarÃa Vallet-RegÃ, Ramón MartÃnez-Máñez Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection published pages: 114-126, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.12.025 |
Acta Biomaterialia 50 | 2019-07-25 |
| 2017 |
M. Vallet-RegÃ, P. Mora-Raimundo, M. Manzano Nanoparticles for the treatment of osteoporosis published pages: 259-274, ISSN: 2375-1495, DOI: 10.3934/bioeng.2017.2.259 |
AIMS Bioengineering 4/2 | 2019-07-25 |
| 2017 |
Renny Mathew, Claudia Turdean-Ionescu, Yang Yu, Baltzar Stevensson, Isabel Izquierdo-Barba, Ana GarcÃa, Daniel Arcos, MarÃa Vallet-RegÃ, Mattias Edén Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO 2 –P 2 O 5 Glasses in Vitro : Insights from Solid-State NMR published pages: 13223-13238, ISSN: 1932-7447, DOI: 10.1021/acs.jpcc.7b03469 |
The Journal of Physical Chemistry C 121/24 | 2019-07-25 |
| 2017 |
Sandra Sánchez-Salcedo, Ana GarcÃa, MarÃa Vallet-Regà Prevention of bacterial adhesion to zwitterionic biocompatible mesoporous glasses published pages: 472-486, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.05.005 |
Acta Biomaterialia 57 | 2019-07-25 |
| 2017 |
Anahà Philippart, Natividad Gómez-Cerezo, Daniel Arcos, Antonio J. Salinas, Elena Boccardi, Maria Vallet-Regi, Aldo R. Boccaccini Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide published pages: 90-97, ISSN: 0022-3093, DOI: 10.1016/j.jnoncrysol.2016.10.031 |
Journal of Non-Crystalline Solids 455 | 2019-07-25 |
| 2018 |
Antonio J. Salinas, José M. Blanco-Bécares, Okan Mersinlioglu, Laura Casarrubios, Daniel Fernández-Villa, MarÃa J. Feito, Teresa Portolés, Blanca González, MarÃa Vallet-Regà Synthesis, Characterization and Biocompatibility of Mesolamellar Calcium Phosphate Hybrids Prepared by Anionic Surfactant Templating published pages: 6880-6891, ISSN: 2365-6549, DOI: 10.1002/slct.201703130 |
ChemistrySelect 3/24 | 2019-07-25 |
| 2018 |
MarÃa RocÃo Villegas, Alejandro Baeza, MarÃa Vallet-Regà Nanotechnological Strategies for Protein Delivery published pages: 1008, ISSN: 1420-3049, DOI: 10.3390/molecules23051008 |
Molecules 23/5 | 2019-07-25 |
| 2017 |
MarÃa Valletâ€RegÃ, Miguel Manzano, Leocadio Rodriguezâ€Mañas, Marta Checa López, Matti Aapro, Lodovico Balducci Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions published pages: 335-342, ISSN: 1083-7159, DOI: 10.1634/theoncologist.2016-0276 |
The Oncologist 22/3 | 2019-07-25 |
| 2018 |
MarÃa Vallet-Regi, Antonio Salinas Role of the Short Distance Order in Glass Reactivity published pages: 415, ISSN: 1996-1944, DOI: 10.3390/ma11030415 |
Materials 11/3 | 2019-07-25 |
| 2017 |
MarÃa Villegas, Lorena Garcia-Uriostegui, Ofelia RodrÃguez, Isabel Izquierdo-Barba, Antonio Salinas, Guillermo Toriz, MarÃa Vallet-RegÃ, Ezequiel Delgado Lysine-Grafted MCM-41 Silica as an Antibacterial Biomaterial published pages: 80, ISSN: 2306-5354, DOI: 10.3390/bioengineering4040080 |
Bioengineering 4/4 | 2019-07-25 |
| 2017 |
Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-RegÃ, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration published pages: 493-504, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.012 |
Acta Biomaterialia 55 | 2019-07-25 |
| 2018 |
Marina MartÃnez-Carmona, Yurii Gun’ko, MarÃa Vallet-Regà ZnO Nanostructures for Drug Delivery and Theranostic Applications published pages: 268, ISSN: 2079-4991, DOI: 10.3390/nano8040268 |
Nanomaterials 8/4 | 2019-07-25 |
| 2018 |
N. Gómez-Cerezo, E. Verron, V. Montouillout, F. Fayon, P. Lagadec, J.M. Bouler, B. Bujoli, D. Arcos, M. Vallet-Regà The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.06.036 |
Acta Biomaterialia | 2019-07-25 |
| 2018 |
Gonzalo Villaverde, Sergio Gómez-Graña, Eduardo Guisasola, Isabel GarcÃa, Christoph Hanske, Luis M. Liz-Marzán, Alejandro Baeza, Maria Vallet-Regà Targeted Chemo-Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment published pages: 1800148, ISSN: 0934-0866, DOI: 10.1002/ppsc.201800148 |
Particle & Particle Systems Characterization | 2019-07-25 |
| 2017 |
Rafaela GarcÃa-Alvarez, Isabel Izquierdo-Barba, MarÃa Vallet-Regà 3D scaffold with effective multidrug sequential release against bacteria biofilm published pages: 113-126, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.11.028 |
Acta Biomaterialia 49 | 2019-07-25 |
| 2018 |
Daniel Pedraza, Jaime DÃez, Isabel-Izquierdo-Barba, Montserrat Colilla, MarÃa Vallet-Regà Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment published pages: 1-12, ISSN: 2299-3932, DOI: 10.1515/bglass-2018-0001 |
Biomedical Glasses 4/1 | 2019-07-25 |
| 2018 |
Marina MartÃnez-Carmona, Daniel Lozano, Montserrat Colilla, MarÃa Vallet-Regà Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment published pages: 393-404, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.11.007 |
Acta Biomaterialia 65 | 2019-07-25 |
| 2018 |
Natalio GarcÃa-Honduvilla, Alejandro Coca, Miguel A Ortega, Cynthia Trejo, Jesús Román, Juan Peña, M Victoria Cabañas, Maria Vallet Regi, Julia Buján Improved connective integration of a degradable 3D-nano-apatite/agarose scaffold subcutaneously implanted in a rat model published pages: 741-752, ISSN: 0885-3282, DOI: 10.1177/0885328218810084 |
Journal of Biomaterials Applications 33/5 | 2019-07-25 |
| 2019 |
Juan L. Paris, Paz de la Torre, M. Victoria Cabañas, Miguel Manzano, Ana I. Flores, MarÃa Vallet-Regà Suicide-gene transfection of tumor-tropic placental stem cells employing ultrasound-responsive nanoparticles published pages: 372-378, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.11.006 |
Acta Biomaterialia 83 | 2019-07-25 |
| 2018 |
Montserrat Colilla, Isabel Izquierdo-Barba, MarÃa Vallet-Regà The Role of Zwitterionic Materials in the Fight against Proteins and Bacteria published pages: 125, ISSN: 2305-6320, DOI: 10.3390/medicines5040125 |
Medicines 5/4 | 2019-07-25 |
| 2018 |
Laura Casarrubios, Natividad Gómez-Cerezo, MarÃa José Feito, MarÃa Vallet-RegÃ, Daniel Arcos, MarÃa Teresa Portolés Incorporation and effects of mesoporous SiO2-CaO nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures published pages: 258-268, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2018.10.019 |
European Journal of Pharmaceutics and Biopharmaceutics 133 | 2019-07-25 |
| 2019 |
Noemà Encinas, Mercedes Angulo, Carlos Astorga, Montserrat Colilla, Isabel Izquierdo-Barba, MarÃa Vallet-Regà Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties published pages: 317-327, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.12.012 |
Acta Biomaterialia 84 | 2019-07-25 |
| 2018 |
Rafael R. Castillo, Daniel Lozano, MarÃa Vallet-Regà Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery published pages: 3677-3685, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00603 |
Bioconjugate Chemistry 29/11 | 2019-07-25 |
| 2018 |
Marina MartÃnez-Carmona, Yurii Gun’ko, MarÃa Vallet-Regà Mesoporous Silica Materials as Drug Delivery: “The Nightmare†of Bacterial Infection published pages: 279, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10040279 |
Pharmaceutics 10/4 | 2019-07-25 |
| 2019 |
I. Izquierdo-Barba, L. Santos-Ruiz, J. Becerra, M.J. Feito, D. Fernández-Villa, M.C. Serrano, I. DÃaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, D. Monopoli, H. Afonso, M.T. Portolés, D. Arcos, M. Vallet-Regà Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment published pages: 456-466, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.11.017 |
Acta Biomaterialia 83 | 2019-07-25 |
| 2019 |
Rafael R. Castillo, Daniel Lozano, Blanca González, Miguel Manzano, Isabel Izquierdo-Barba, MarÃa Vallet-Regà Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update published pages: 1-25, ISSN: 1742-5247, DOI: 10.1080/17425247.2019.1598375 |
Expert Opinion on Drug Delivery | 2019-07-25 |
| 2019 |
MarÃa Vallet-Regà Bioceramics: from bone substitutes to nanoparticles for drug delivery published pages: , ISSN: 0033-4545, DOI: 10.1515/pac-2018-0505 |
Pure and Applied Chemistry 0/0 | 2019-07-25 |
| 2019 |
Miguel Manzano, MarÃa Vallet-Regà Ultrasound responsive mesoporous silica nanoparticles for biomedical applications published pages: 2731-2740, ISSN: 1359-7345, DOI: 10.1039/c8cc09389j |
Chemical Communications 55/19 | 2019-07-25 |
| 2019 |
Juan L. Paris, Nuria Lafuente-Gómez, M. Victoria Cabañas, Jesús Román, Juan Peña, MarÃa Vallet-Regà Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties published pages: 441-449, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.01.013 |
Acta Biomaterialia 86 | 2019-07-25 |
| 2019 |
Sandra Montalvo-Quiros, Guillermo Aragoneses-Cazorla, Laura Garcia-Alcalde, MarÃa Vallet-RegÃ, Blanca González, Jose L. Luque-Garcia Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: insights into the action mechanisms using quantitative proteomics published pages: 4531-4545, ISSN: 2040-3364, DOI: 10.1039/c8nr07667g |
Nanoscale 11/10 | 2019-07-25 |
| 2019 |
Rafael R. Castillo, MarÃa Vallet-Regà Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety. published pages: 929, ISSN: 1422-0067, DOI: 10.3390/ijms20040929 |
International Journal of Molecular Sciences 20/4 | 2019-07-25 |
| 2018 |
M.V. Cabañas, D. Lozano, A. Torres-Pardo, C. Sobrino, J. González-Calbet, D. Arcos, M. Vallet-Regà Features of aminopropyl modified mesoporous silica nanoparticles. Implications on the active targeting capability published pages: 260-269, ISSN: 0254-0584, DOI: 10.1016/j.matchemphys.2018.09.005 |
Materials Chemistry and Physics 220 | 2019-07-25 |
| 2018 |
Lorena Polo, Natividad Gómez-Cerezo, Alba GarcÃa-Fernández, Elena Aznar, Jose Luis Vivancos, Daniel Arcos, MarÃa Vallet-RegÃ, Ramón MartÃnez-Máñez Mesoporous bioactive glasses equipped with stimuli-responsive molecular gates for the controlled delivery of levofloxacin against bacteria published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201803301 |
Chemistry - A European Journal | 2019-07-25 |
| 2018 |
Rebeca Pérez, Sandra Sanchez-Salcedo, Daniel Lozano, Clara Heras, Pedro Esbrit, MarÃa Vallet-RegÃ, Antonio Salinas Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin published pages: 592, ISSN: 2079-4991, DOI: 10.3390/nano8080592 |
Nanomaterials 8/8 | 2019-07-25 |
| 2018 |
Preethi Balasubramanian, Antonio J. Salinas, Sandra Sanchez-Salcedo, Rainer Detsch, Maria Vallet-Regi, Aldo R. Boccaccini Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO published pages: 217-224, ISSN: 0022-3093, DOI: 10.1016/j.jnoncrysol.2018.07.073 |
Journal of Non-Crystalline Solids 500 | 2019-07-25 |
| 2019 |
Gonzalo Villaverde, Arantzazu Alfranca, Ãfrica Gonzalez-Murillo, Gustavo J. Melen, Rafael R. Castillo, Manuel RamÃrez, Alejandro Baeza, MarÃa Vallet-Regà Molecular Scaffolds as Double-Targeting Agents For the Diagnosis and Treatment of Neuroblastoma published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201811691 |
Angewandte Chemie International Edition | 2019-07-25 |
| 2019 |
Noemà Encinas, Mercedes Angulo, Carlos Astorga, Montserrat Colilla, Isabel Izquierdo-Barba, MarÃa Vallet-Regà Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties published pages: 317-327, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.12.012 |
Acta Biomaterialia 84 | 2019-07-25 |
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